Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives

Detalhes bibliográficos
Autor(a) principal: Cunico, Wilson
Data de Publicação: 2011
Outros Autores: Gomes, Claudia R. B., Ferreira, Maria L. G., Ferreira, Thaís G., Cardinot, Danielle, Souza, Marcus V. N. de, Lourenço, Maria C. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37021
Resumo: 2020-11-13
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spelling Cunico, WilsonGomes, Claudia R. B.Ferreira, Maria L. G.Ferreira, Thaís G.Cardinot, DanielleSouza, Marcus V. N. deLourenço, Maria C. S.2019-11-13T12:52:28Z2019-11-13T12:52:28Z2011CUNICO, Wilson et al. Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives. European Journal of Medicinal Chemistry, v. 46, p. 974-978, 2011.0223-5234https://www.arca.fiocruz.br/handle/icict/3702110.1016/j.ejmech.2011.01.0041768-3254engElsevierSynthesis and anti-mycobacterial activity of novel amino alcohol derivativesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-11-13Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Universidade Federal de Pelotas. Núcleo de Química Aplicada. Departamento de Química Orgânica. Pelotas, RS, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisas Clínicas Evandro Chagas. Departamento de Bacteriologia. Rio de Janeiro, RJ, Brasil.Thirteen new hydroxyethylamines have been synthesized from reactions of (2S,3S) Boc-phenylalanineepoxide, piperonylamine and arenesulfonyl chlorides in good yields. These compounds were evaluated as antibacterial agents against Mycobacterium tuberculosis H37Rv using the Alamar Blue susceptibility testand their activity expressedas the minimum inhibitory concentration (MIC) in µM. Two amino alcohols displayed significant activity when compared with first line drug ethambutol (EMB). Therefore this class of compounds could be a good starting point to develop new lead compounds in the treatment of tuberculosis.TuberculosisAmino alcoholsHydroxyethylamineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/37021/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Cunico_Wilson_etal_INI_2011.pdfve_Cunico_Wilson_etal_INI_2011.pdfapplication/pdf199982https://www.arca.fiocruz.br/bitstream/icict/37021/2/ve_Cunico_Wilson_etal_INI_2011.pdfbd4c2cb9691d01b00ebbe5075fa0a011MD52TEXTve_Cunico_Wilson_etal_INI_2011.pdf.txtve_Cunico_Wilson_etal_INI_2011.pdf.txtExtracted texttext/plain29051https://www.arca.fiocruz.br/bitstream/icict/37021/3/ve_Cunico_Wilson_etal_INI_2011.pdf.txtc0ef483c0a7bb7f415179306f4e8ff8cMD53icict/370212021-03-24 16:32:38.886oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:38Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives
title Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives
spellingShingle Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives
Cunico, Wilson
Tuberculosis
Amino alcohols
Hydroxyethylamine
title_short Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives
title_full Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives
title_fullStr Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives
title_full_unstemmed Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives
title_sort Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives
author Cunico, Wilson
author_facet Cunico, Wilson
Gomes, Claudia R. B.
Ferreira, Maria L. G.
Ferreira, Thaís G.
Cardinot, Danielle
Souza, Marcus V. N. de
Lourenço, Maria C. S.
author_role author
author2 Gomes, Claudia R. B.
Ferreira, Maria L. G.
Ferreira, Thaís G.
Cardinot, Danielle
Souza, Marcus V. N. de
Lourenço, Maria C. S.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cunico, Wilson
Gomes, Claudia R. B.
Ferreira, Maria L. G.
Ferreira, Thaís G.
Cardinot, Danielle
Souza, Marcus V. N. de
Lourenço, Maria C. S.
dc.subject.en.pt_BR.fl_str_mv Tuberculosis
Amino alcohols
Hydroxyethylamine
topic Tuberculosis
Amino alcohols
Hydroxyethylamine
description 2020-11-13
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2019-11-13T12:52:28Z
dc.date.available.fl_str_mv 2019-11-13T12:52:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CUNICO, Wilson et al. Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives. European Journal of Medicinal Chemistry, v. 46, p. 974-978, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37021
dc.identifier.issn.pt_BR.fl_str_mv 0223-5234
dc.identifier.doi.none.fl_str_mv 10.1016/j.ejmech.2011.01.004
dc.identifier.eissn.none.fl_str_mv 1768-3254
identifier_str_mv CUNICO, Wilson et al. Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives. European Journal of Medicinal Chemistry, v. 46, p. 974-978, 2011.
0223-5234
10.1016/j.ejmech.2011.01.004
1768-3254
url https://www.arca.fiocruz.br/handle/icict/37021
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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