Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/37021 |
Resumo: | 2020-11-13 |
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Cunico, WilsonGomes, Claudia R. B.Ferreira, Maria L. G.Ferreira, Thaís G.Cardinot, DanielleSouza, Marcus V. N. deLourenço, Maria C. S.2019-11-13T12:52:28Z2019-11-13T12:52:28Z2011CUNICO, Wilson et al. Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives. European Journal of Medicinal Chemistry, v. 46, p. 974-978, 2011.0223-5234https://www.arca.fiocruz.br/handle/icict/3702110.1016/j.ejmech.2011.01.0041768-3254engElsevierSynthesis and anti-mycobacterial activity of novel amino alcohol derivativesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-11-13Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Universidade Federal de Pelotas. Núcleo de Química Aplicada. Departamento de Química Orgânica. Pelotas, RS, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisas Clínicas Evandro Chagas. Departamento de Bacteriologia. Rio de Janeiro, RJ, Brasil.Thirteen new hydroxyethylamines have been synthesized from reactions of (2S,3S) Boc-phenylalanineepoxide, piperonylamine and arenesulfonyl chlorides in good yields. These compounds were evaluated as antibacterial agents against Mycobacterium tuberculosis H37Rv using the Alamar Blue susceptibility testand their activity expressedas the minimum inhibitory concentration (MIC) in µM. Two amino alcohols displayed significant activity when compared with first line drug ethambutol (EMB). Therefore this class of compounds could be a good starting point to develop new lead compounds in the treatment of tuberculosis.TuberculosisAmino alcoholsHydroxyethylamineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/37021/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Cunico_Wilson_etal_INI_2011.pdfve_Cunico_Wilson_etal_INI_2011.pdfapplication/pdf199982https://www.arca.fiocruz.br/bitstream/icict/37021/2/ve_Cunico_Wilson_etal_INI_2011.pdfbd4c2cb9691d01b00ebbe5075fa0a011MD52TEXTve_Cunico_Wilson_etal_INI_2011.pdf.txtve_Cunico_Wilson_etal_INI_2011.pdf.txtExtracted texttext/plain29051https://www.arca.fiocruz.br/bitstream/icict/37021/3/ve_Cunico_Wilson_etal_INI_2011.pdf.txtc0ef483c0a7bb7f415179306f4e8ff8cMD53icict/370212021-03-24 16:32:38.886oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:38Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives |
title |
Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives |
spellingShingle |
Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives Cunico, Wilson Tuberculosis Amino alcohols Hydroxyethylamine |
title_short |
Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives |
title_full |
Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives |
title_fullStr |
Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives |
title_full_unstemmed |
Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives |
title_sort |
Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives |
author |
Cunico, Wilson |
author_facet |
Cunico, Wilson Gomes, Claudia R. B. Ferreira, Maria L. G. Ferreira, Thaís G. Cardinot, Danielle Souza, Marcus V. N. de Lourenço, Maria C. S. |
author_role |
author |
author2 |
Gomes, Claudia R. B. Ferreira, Maria L. G. Ferreira, Thaís G. Cardinot, Danielle Souza, Marcus V. N. de Lourenço, Maria C. S. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Cunico, Wilson Gomes, Claudia R. B. Ferreira, Maria L. G. Ferreira, Thaís G. Cardinot, Danielle Souza, Marcus V. N. de Lourenço, Maria C. S. |
dc.subject.en.pt_BR.fl_str_mv |
Tuberculosis Amino alcohols Hydroxyethylamine |
topic |
Tuberculosis Amino alcohols Hydroxyethylamine |
description |
2020-11-13 |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2019-11-13T12:52:28Z |
dc.date.available.fl_str_mv |
2019-11-13T12:52:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CUNICO, Wilson et al. Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives. European Journal of Medicinal Chemistry, v. 46, p. 974-978, 2011. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/37021 |
dc.identifier.issn.pt_BR.fl_str_mv |
0223-5234 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.ejmech.2011.01.004 |
dc.identifier.eissn.none.fl_str_mv |
1768-3254 |
identifier_str_mv |
CUNICO, Wilson et al. Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives. European Journal of Medicinal Chemistry, v. 46, p. 974-978, 2011. 0223-5234 10.1016/j.ejmech.2011.01.004 1768-3254 |
url |
https://www.arca.fiocruz.br/handle/icict/37021 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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FIOCRUZ |
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