A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119

Detalhes bibliográficos
Autor(a) principal: Fonseca, Jairo Andres
Data de Publicação: 2016
Outros Autores: Cabrera-Mora, Monica, Singh, Balwan, Ferreira, Joseli Oliveira, Lima Junior, Josué da Costa, Calle, J. Mauricio Calvo, Lozano, Jose Manuel, Moreno, Alberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/17818
Resumo: Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA / Emory University. Department of Medicine. Division of Infectious Diseases. Atlanta, GA, USA.
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spelling Fonseca, Jairo AndresCabrera-Mora, MonicaSingh, BalwanFerreira, Joseli OliveiraLima Junior, Josué da CostaCalle, J. Mauricio CalvoLozano, Jose ManuelMoreno, Alberto2017-02-15T12:04:18Z2017-02-15T12:04:18Z2016FONSECA, Jairo Andres; et al. A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119. Scientific Reports, v.6:34527, 18p, 2016.2045-2322https://www.arca.fiocruz.br/handle/icict/1781810.1038/srep34527engNature Publishing GroupMaláriaPlasmodium vivaxVacinaPlasmodium vivax MSP119MalariaPlasmodium vivaxP. vivax Merozoite Surface Protein 1 (PvMSP119VaccineA chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEmory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA / Emory University. Department of Medicine. Division of Infectious Diseases. Atlanta, GA, USA.Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA.Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil.University of Massachusetts Medical School. Department of Pathology. Worcester, MA, USA.Universidad Nacional de Colombia. Department of Pharmacy. Molecular Mimetism of Infectious Agents Unit. Bogotá, Colombia.Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA / Emory University. Department of Medicine. Division of Infectious Diseases. Atlanta, GA, USA.The most widespread Plasmodium species, Plasmodium vivax, poses a significant public health threat. An effective vaccine is needed to reduce global malaria burden. Of the erythrocytic stage vaccine candidates, the 19 kDa fragment of the P. vivax Merozoite Surface Protein 1 (PvMSP119) is one of the most promising. Our group has previously defined several promiscuous T helper epitopes within the PvMSP1 protein, with features that allow them to bind multiple MHC class II alleles. We describe here a P. vivax recombinant modular chimera based on MSP1 (PvRMC-MSP1) that includes defined T cell epitopes genetically fused to PvMSP119. This vaccine candidate preserved structural elements of the native PvMSP119 and elicited cytophilic antibody responses, and CD4+ and CD8+ T cells capable of recognizing PvMSP119. Although CD8+ T cells that recognize blood stage antigens have been reported to control blood infection, CD8+ T cell responses induced by P. falciparum or P. vivax vaccine candidates based on MSP119 have not been reported. To our knowledge, this is the first time a protein based subunit vaccine has been able to induce CD8+ T cell against PvMSP119. The PvRMC-MSP1 protein was also recognized by naturally acquired antibodies from individuals living in malaria endemic areas with an antibody profile associated with protection from infection. These features make PvRMC-MSP1 a promising vaccine candidate.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17818/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjoseli_ferreira_etal_IOC_2016.pdfjoseli_ferreira_etal_IOC_2016.pdfapplication/pdf1481275https://www.arca.fiocruz.br/bitstream/icict/17818/2/joseli_ferreira_etal_IOC_2016.pdf02e9a8a4d01eed2ae485bc039d32a797MD52TEXTjoseli_ferreira_etal_IOC_2016.pdf.txtjoseli_ferreira_etal_IOC_2016.pdf.txtExtracted texttext/plain102207https://www.arca.fiocruz.br/bitstream/icict/17818/3/joseli_ferreira_etal_IOC_2016.pdf.txt751eb225b2c6e3b28329a812092ee73aMD53icict/178182022-06-24 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dc.title.pt_BR.fl_str_mv A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119
title A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119
spellingShingle A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119
Fonseca, Jairo Andres
Malária
Plasmodium vivax
Vacina
Plasmodium vivax MSP119
Malaria
Plasmodium vivax
P. vivax Merozoite Surface Protein 1 (PvMSP119
Vaccine
title_short A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119
title_full A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119
title_fullStr A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119
title_full_unstemmed A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119
title_sort A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119
author Fonseca, Jairo Andres
author_facet Fonseca, Jairo Andres
Cabrera-Mora, Monica
Singh, Balwan
Ferreira, Joseli Oliveira
Lima Junior, Josué da Costa
Calle, J. Mauricio Calvo
Lozano, Jose Manuel
Moreno, Alberto
author_role author
author2 Cabrera-Mora, Monica
Singh, Balwan
Ferreira, Joseli Oliveira
Lima Junior, Josué da Costa
Calle, J. Mauricio Calvo
Lozano, Jose Manuel
Moreno, Alberto
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fonseca, Jairo Andres
Cabrera-Mora, Monica
Singh, Balwan
Ferreira, Joseli Oliveira
Lima Junior, Josué da Costa
Calle, J. Mauricio Calvo
Lozano, Jose Manuel
Moreno, Alberto
dc.subject.other.pt_BR.fl_str_mv Malária
Plasmodium vivax
Vacina
Plasmodium vivax MSP119
topic Malária
Plasmodium vivax
Vacina
Plasmodium vivax MSP119
Malaria
Plasmodium vivax
P. vivax Merozoite Surface Protein 1 (PvMSP119
Vaccine
dc.subject.en.pt_BR.fl_str_mv Malaria
Plasmodium vivax
P. vivax Merozoite Surface Protein 1 (PvMSP119
Vaccine
description Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA / Emory University. Department of Medicine. Division of Infectious Diseases. Atlanta, GA, USA.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-02-15T12:04:18Z
dc.date.available.fl_str_mv 2017-02-15T12:04:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FONSECA, Jairo Andres; et al. A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119. Scientific Reports, v.6:34527, 18p, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/17818
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/srep34527
identifier_str_mv FONSECA, Jairo Andres; et al. A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119. Scientific Reports, v.6:34527, 18p, 2016.
2045-2322
10.1038/srep34527
url https://www.arca.fiocruz.br/handle/icict/17818
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/17818/1/license.txt
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