Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31991 |
Resumo: | We are grateful for the staff of the Department of Pathology at the IEC, especially Valter Miranda Campos and Maria de Lourdes Gomes Lima, personal of the Department of Arbovirology and Hemorrhagic Fevers at the IEC, and Adlai Raimundo Sousa for their technical support, as well as staff of the Public Health Laboratories of Ceará, Espírito Santo, Pernambuco, and Rio Grande do Norte States. |
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Azevedo, Raimunda S. S.Araujo, Marialva T.Oliveira, Consuelo S.Filho, Arnaldo Jorge MartinsNunes, Bruno T. D.Henriques, Daniele F.Silva, Eliana V. P.Carvalho, Valéria L.Chiang, Jannifer O.Martins, Lívia C.Vasconcelos, Barbara C. B.Sousa, Jorge R.Araujo, Fernanda Montenegro C.Ribeiro, Erlane M.Castro, Andrezza R. P.Queiroz, Maria G. L.deVerotti, Mariana PastorelloNunes, Márcio R. T.Cruz, Ana C. R.Rodrigues, Sueli G.Shi, Pei-YongQuaresma, Juarez A. S.Tesh, Robert B.Vasconcelos, Pedro F. C.2019-03-07T19:30:15Z2019-03-07T19:30:15Z2018AZEVEDO, Raimunda S. S. et al. Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage. Journal of Clinical Medicine, v. 7, n. 496, p.1-13, 2018.2077-0383https://www.arca.fiocruz.br/handle/icict/3199110.3390/jcm712049610.3390/jcm7120496We are grateful for the staff of the Department of Pathology at the IEC, especially Valter Miranda Campos and Maria de Lourdes Gomes Lima, personal of the Department of Arbovirology and Hemorrhagic Fevers at the IEC, and Adlai Raimundo Sousa for their technical support, as well as staff of the Public Health Laboratories of Ceará, Espírito Santo, Pernambuco, and Rio Grande do Norte States.This study is supported by the Evandro Chagas Institute, Ministry of Health of Brazil, CNPq by PFCV (303999/2016-0, 439971/2016-0 and 440405/2016-5), CAPES by PFCV (Zika Fast-track).Ministério da Saúde. Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil / Universidade do Estado do Pará. Centro de Ciências Biológicas e da Saúde. Belém, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Universidade do Estado do Pará. Centro de Ciências Biológicas e da Saúde. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil / Universidade Federal do Pará. Programa de Pós-graduação em Doenças Tropicais. Belém, PA, Brasil.Secretaria de Saúde Pública do Ceará. Laboratório Central. Fortaleza, CE, Brasil.Secretaria de Saúde Pública do Ceará. Hospital Geral César Cals. Fortaleza, CE, Brasil.Secretaria de Saúde Pública do Ceará. Hospital Geral César Cals. Fortaleza, CE, Brasil.Secretaria de Saúde Pública do Rio Grande do Norte. Laboratório Central. Natal, RN, Brasil.Fundação Oswaldo Cruz. Fundação para o Desenvolvimento Científico e Tecnológico em Saúde. Brasília, DF, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil.University of Texas Medical Branch. Department of Pathology. Galveston, TX, USA.Universidade do Estado do Pará. Centro de Ciências Biológicas e da Saúde. Belém, PA, Brasil / Universidade Federal do Pará. Programa de Pós-graduação em Doenças Tropicais. Belém, PA, Brasil.University of Texas Medical Branch. Department of Pathology. Galveston, TX, USA.Ministério da Saúde. Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brasil / Universidade do Estado do Pará. Centro de Ciências Biológicas e da Saúde. Belém, PA, Brasil.The recent Zika virus(ZIKV) epidemic in Brazil was characterized by a range of different clinical presentations, particularly microcephaly, Guillain-Barré syndrome, and death. In this context, we determined the causal relationship between fatal microcephaly cases and ZIKV infection. Methods: Twelve fatal cases of neonates, whose mothers were infected with ZIKV during pregnancy, were examined; cases included nine neonatal deaths due to microcephaly, one miscarriage, and two stillbirths. Tissue samples were obtained from all cases at necropsy and were submitted for virological investigation (RT-qPCR and virus isolation) and/or histopathology (hematoxylin and eosin staining) and immunohistochemical assay for the detection of ZIKV antigens. Results: ZIKV antigens and/or ZIKV RNA were detected in tissue samples of all 12 cases examined. ZIKV was recovered in one case. Results of the virological and immunohistochemical analyses, as well as the anatomic abnormalities and histopathologic changes observed at necropsy on the 12 fatal cases, are presented. Conclusions: Data from these 12 cases provide strong evidence of the causal relationship between ZIKV and congenital disease in fetuses of women who were infected with the virus during pregnancy.porMDPIVírus ZikaMicrocefaliaSíndrome congênitaZIKV RNAZIKV antigenZika virusMicrocephalyCongenital syndromeZIKV RNAZIKV antigenZika Virus Epidemic in Brazil. II. 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| dc.title.pt_BR.fl_str_mv |
Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage |
| title |
Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage |
| spellingShingle |
Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage Azevedo, Raimunda S. S. Vírus Zika Microcefalia Síndrome congênita ZIKV RNA ZIKV antigen Zika virus Microcephaly Congenital syndrome ZIKV RNA ZIKV antigen |
| title_short |
Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage |
| title_full |
Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage |
| title_fullStr |
Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage |
| title_full_unstemmed |
Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage |
| title_sort |
Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage |
| author |
Azevedo, Raimunda S. S. |
| author_facet |
Azevedo, Raimunda S. S. Araujo, Marialva T. Oliveira, Consuelo S. Filho, Arnaldo Jorge Martins Nunes, Bruno T. D. Henriques, Daniele F. Silva, Eliana V. P. Carvalho, Valéria L. Chiang, Jannifer O. Martins, Lívia C. Vasconcelos, Barbara C. B. Sousa, Jorge R. Araujo, Fernanda Montenegro C. Ribeiro, Erlane M. Castro, Andrezza R. P. Queiroz, Maria G. L.de Verotti, Mariana Pastorello Nunes, Márcio R. T. Cruz, Ana C. R. Rodrigues, Sueli G. Shi, Pei-Yong Quaresma, Juarez A. S. Tesh, Robert B. Vasconcelos, Pedro F. C. |
| author_role |
author |
| author2 |
Araujo, Marialva T. Oliveira, Consuelo S. Filho, Arnaldo Jorge Martins Nunes, Bruno T. D. Henriques, Daniele F. Silva, Eliana V. P. Carvalho, Valéria L. Chiang, Jannifer O. Martins, Lívia C. Vasconcelos, Barbara C. B. Sousa, Jorge R. Araujo, Fernanda Montenegro C. Ribeiro, Erlane M. Castro, Andrezza R. P. Queiroz, Maria G. L.de Verotti, Mariana Pastorello Nunes, Márcio R. T. Cruz, Ana C. R. Rodrigues, Sueli G. Shi, Pei-Yong Quaresma, Juarez A. S. Tesh, Robert B. Vasconcelos, Pedro F. C. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Azevedo, Raimunda S. S. Araujo, Marialva T. Oliveira, Consuelo S. Filho, Arnaldo Jorge Martins Nunes, Bruno T. D. Henriques, Daniele F. Silva, Eliana V. P. Carvalho, Valéria L. Chiang, Jannifer O. Martins, Lívia C. Vasconcelos, Barbara C. B. Sousa, Jorge R. Araujo, Fernanda Montenegro C. Ribeiro, Erlane M. Castro, Andrezza R. P. Queiroz, Maria G. L.de Verotti, Mariana Pastorello Nunes, Márcio R. T. Cruz, Ana C. R. Rodrigues, Sueli G. Shi, Pei-Yong Quaresma, Juarez A. S. Tesh, Robert B. Vasconcelos, Pedro F. C. |
| dc.subject.other.pt_BR.fl_str_mv |
Vírus Zika Microcefalia Síndrome congênita ZIKV RNA ZIKV antigen |
| topic |
Vírus Zika Microcefalia Síndrome congênita ZIKV RNA ZIKV antigen Zika virus Microcephaly Congenital syndrome ZIKV RNA ZIKV antigen |
| dc.subject.en.pt_BR.fl_str_mv |
Zika virus Microcephaly Congenital syndrome ZIKV RNA ZIKV antigen |
| description |
We are grateful for the staff of the Department of Pathology at the IEC, especially Valter Miranda Campos and Maria de Lourdes Gomes Lima, personal of the Department of Arbovirology and Hemorrhagic Fevers at the IEC, and Adlai Raimundo Sousa for their technical support, as well as staff of the Public Health Laboratories of Ceará, Espírito Santo, Pernambuco, and Rio Grande do Norte States. |
| publishDate |
2018 |
| dc.date.issued.fl_str_mv |
2018 |
| dc.date.accessioned.fl_str_mv |
2019-03-07T19:30:15Z |
| dc.date.available.fl_str_mv |
2019-03-07T19:30:15Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
AZEVEDO, Raimunda S. S. et al. Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage. Journal of Clinical Medicine, v. 7, n. 496, p.1-13, 2018. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/31991 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2077-0383 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/jcm7120496 |
| dc.identifier.eissn.none.fl_str_mv |
10.3390/jcm7120496 |
| identifier_str_mv |
AZEVEDO, Raimunda S. S. et al. Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage. Journal of Clinical Medicine, v. 7, n. 496, p.1-13, 2018. 2077-0383 10.3390/jcm7120496 |
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https://www.arca.fiocruz.br/handle/icict/31991 |
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por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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MDPI |
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MDPI |
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Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
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repositorio.arca@fiocruz.br |
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