Zika virus infection in pregnant women in Rio de Janeiro: preliminary report

Detalhes bibliográficos
Autor(a) principal: Brasil, Patrícia
Data de Publicação: 2016
Outros Autores: Pereira, José P., Gabaglia, Claudia Raja, Damasceno, Luana, Wakimoto, Mayumi, Nogueira, Rita M. Ribeiro, Sequeira, Patrícia Carvalho de, Siqueira, André Machado, Carvalho, Liege M. Abreu de, Cunha, Denise Cotrim da, Calvet, Guilherme A., Neves, Elizabeth S., Moreira, Maria E., Baião, Ana E. Rodrigues, Carvalho, Paulo R. Nassar de, Janzen, Carla, Valderramos, Stephanie G., Cherry, James D., Filippis, Ana M. Bispo de, Nielsen-Saines, Karin
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13063
Resumo: Artigo liberado em acesso aberto como parte do acordo para tornar público todos os dados produzidos sobre o vírus zika - Compartilhamento de dados em emergências de saúde pública - http://www.wellcome.ac.uk/News/Media-office/Press-releases/2016/WTP060169.htm
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spelling Brasil, PatríciaPereira, José P.Gabaglia, Claudia RajaDamasceno, LuanaWakimoto, MayumiNogueira, Rita M. RibeiroSequeira, Patrícia Carvalho deSiqueira, André MachadoCarvalho, Liege M. Abreu deCunha, Denise Cotrim daCalvet, Guilherme A.Neves, Elizabeth S.Moreira, Maria E.Baião, Ana E. RodriguesCarvalho, Paulo R. Nassar deJanzen, CarlaValderramos, Stephanie G.Cherry, James D.Filippis, Ana M. Bispo deNielsen-Saines, Karin2016-03-09T11:54:02Z2016-03-09T11:54:02Z2016BRASIL, Patrícia et al. Zika virus infection in pregnant women in Rio de Janeiro: preliminary report. The New England Journal of Medicine, Massachusetts, March 8, p. 1-11, 2016.0028-4793https://www.arca.fiocruz.br/handle/icict/1306310.1056/NEJMoa1602412Artigo liberado em acesso aberto como parte do acordo para tornar público todos os dados produzidos sobre o vírus zika - Compartilhamento de dados em emergências de saúde pública - http://www.wellcome.ac.uk/News/Media-office/Press-releases/2016/WTP060169.htmVersão final do artigo - handle https://www.arca.fiocruz.br/handle/icict/17780Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Biomedical Research Institute of Southern California. Oceanside, California, EUA.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.David Geffen UCLA School of Medicine, Los Angeles, EUA.David Geffen UCLA School of Medicine, Los Angeles, EUA.David Geffen UCLA School of Medicine, Los Angeles, EUA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.David Geffen UCLA School of Medicine, Los Angeles, EUA.BACKGROUND Zika virus (ZIKV) has been linked to neonatal microcephaly. To characterize the spectrum of ZIKV disease in pregnancy, we followed patients in Rio de Janeiro to describe clinical manifestations in mothers and repercussions of acute ZIKV infection in fetuses. METHODS We enrolled pregnant women in whom a rash had developed within the previous 5 days and tested blood and urine specimens for ZIKV by reverse-transcriptase–polymerasechain-reaction assays. We followed the women prospectively and collected clinical and ultrasonographic data. RESULTS A total of 88 women were enrolled from September 2015 through February 2016; of these 88 women, 72 (82%) tested positive for ZIKV in blood, urine, or both. The timing of acute ZIKV infection ranged from 5 to 38 weeks of gestation. Predominant clinical features included pruritic descending macular or maculopapular rash, arthralgias, conjunctival injection, and headache; 28% had fever (short-term and low-grade).Women who were positive for ZIKV were more likely than those who were negative for the virus to have maculopapular rash (44% vs. 12%, P=0.02), conjunctival involvement (58% vs. 13%, P=0.002), and lymphadenopathy (40% vs. 7%, P=0.02). Fetal ultrasonography was performed in 42 ZIKV-positive women (58%) and in all ZIKV-negative women. Fetal abnormalities were detected by Doppler ultrasonography in 12 of the 42 ZIKV-positive women (29%) and in none of the 16 ZIKV-negative women. Adverse findings included fetal deaths at 36 and 38 weeks of gestation (2 fetuses), in utero growth restriction with or without microcephaly (5 fetuses), ventricular calcifications or other central nervous system (CNS) lesions (7 fetuses), and abnormal amniotic fluid volume or cerebral or umbilical artery flow (7 fetuses). To date, 8 of the 42 women in whom fetal ultrasonography was performed have delivered their babies, and the ultrasonographic findings have been confirmed. CONCLUSIONS Despite mild clinical symptoms, ZIKV infection during pregnancy appears to be associated with grave outcomes, including fetal death, placental insufficiency, fetal growth restriction, and CNS injury.porMassachusetts Medical SocietyVírus ZikaMicrocefaliaDoença ZIKV na gravidezAedes aegyptiZika VirusMicrocephalyZIKV disease in pregnancyAedes aegyptiAedesMicrocefaliaZika virus infection in pregnant women in Rio de Janeiro: preliminary reportinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13063/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALZika Virus Infection in Pregnant Women - preliminary report.pdfZika Virus Infection in Pregnant Women - preliminary report.pdfapplication/pdf646105https://www.arca.fiocruz.br/bitstream/icict/13063/2/Zika%20Virus%20Infection%20in%20Pregnant%20Women%20-%20preliminary%20report.pdf76b9427d455f2a5cbb1aa17b53e4cfc6MD52TEXTZika Virus Infection in Pregnant Women - 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dc.title.pt_BR.fl_str_mv Zika virus infection in pregnant women in Rio de Janeiro: preliminary report
title Zika virus infection in pregnant women in Rio de Janeiro: preliminary report
spellingShingle Zika virus infection in pregnant women in Rio de Janeiro: preliminary report
Brasil, Patrícia
Vírus Zika
Microcefalia
Doença ZIKV na gravidez
Aedes aegypti
Zika Virus
Microcephaly
ZIKV disease in pregnancy
Aedes aegypti
Aedes
Microcefalia
title_short Zika virus infection in pregnant women in Rio de Janeiro: preliminary report
title_full Zika virus infection in pregnant women in Rio de Janeiro: preliminary report
title_fullStr Zika virus infection in pregnant women in Rio de Janeiro: preliminary report
title_full_unstemmed Zika virus infection in pregnant women in Rio de Janeiro: preliminary report
title_sort Zika virus infection in pregnant women in Rio de Janeiro: preliminary report
author Brasil, Patrícia
author_facet Brasil, Patrícia
Pereira, José P.
Gabaglia, Claudia Raja
Damasceno, Luana
Wakimoto, Mayumi
Nogueira, Rita M. Ribeiro
Sequeira, Patrícia Carvalho de
Siqueira, André Machado
Carvalho, Liege M. Abreu de
Cunha, Denise Cotrim da
Calvet, Guilherme A.
Neves, Elizabeth S.
Moreira, Maria E.
Baião, Ana E. Rodrigues
Carvalho, Paulo R. Nassar de
Janzen, Carla
Valderramos, Stephanie G.
Cherry, James D.
Filippis, Ana M. Bispo de
Nielsen-Saines, Karin
author_role author
author2 Pereira, José P.
Gabaglia, Claudia Raja
Damasceno, Luana
Wakimoto, Mayumi
Nogueira, Rita M. Ribeiro
Sequeira, Patrícia Carvalho de
Siqueira, André Machado
Carvalho, Liege M. Abreu de
Cunha, Denise Cotrim da
Calvet, Guilherme A.
Neves, Elizabeth S.
Moreira, Maria E.
Baião, Ana E. Rodrigues
Carvalho, Paulo R. Nassar de
Janzen, Carla
Valderramos, Stephanie G.
Cherry, James D.
Filippis, Ana M. Bispo de
Nielsen-Saines, Karin
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Brasil, Patrícia
Pereira, José P.
Gabaglia, Claudia Raja
Damasceno, Luana
Wakimoto, Mayumi
Nogueira, Rita M. Ribeiro
Sequeira, Patrícia Carvalho de
Siqueira, André Machado
Carvalho, Liege M. Abreu de
Cunha, Denise Cotrim da
Calvet, Guilherme A.
Neves, Elizabeth S.
Moreira, Maria E.
Baião, Ana E. Rodrigues
Carvalho, Paulo R. Nassar de
Janzen, Carla
Valderramos, Stephanie G.
Cherry, James D.
Filippis, Ana M. Bispo de
Nielsen-Saines, Karin
dc.subject.other.pt_BR.fl_str_mv Vírus Zika
Microcefalia
Doença ZIKV na gravidez
Aedes aegypti
topic Vírus Zika
Microcefalia
Doença ZIKV na gravidez
Aedes aegypti
Zika Virus
Microcephaly
ZIKV disease in pregnancy
Aedes aegypti
Aedes
Microcefalia
dc.subject.en.pt_BR.fl_str_mv Zika Virus
dc.subject.en.none.fl_str_mv Microcephaly
ZIKV disease in pregnancy
Aedes aegypti
dc.subject.decs.pt_BR.fl_str_mv Aedes
Microcefalia
description Artigo liberado em acesso aberto como parte do acordo para tornar público todos os dados produzidos sobre o vírus zika - Compartilhamento de dados em emergências de saúde pública - http://www.wellcome.ac.uk/News/Media-office/Press-releases/2016/WTP060169.htm
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-03-09T11:54:02Z
dc.date.available.fl_str_mv 2016-03-09T11:54:02Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv BRASIL, Patrícia et al. Zika virus infection in pregnant women in Rio de Janeiro: preliminary report. The New England Journal of Medicine, Massachusetts, March 8, p. 1-11, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13063
dc.identifier.issn.none.fl_str_mv 0028-4793
dc.identifier.doi.none.fl_str_mv 10.1056/NEJMoa1602412
identifier_str_mv BRASIL, Patrícia et al. Zika virus infection in pregnant women in Rio de Janeiro: preliminary report. The New England Journal of Medicine, Massachusetts, March 8, p. 1-11, 2016.
0028-4793
10.1056/NEJMoa1602412
url https://www.arca.fiocruz.br/handle/icict/13063
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dc.publisher.none.fl_str_mv Massachusetts Medical Society
publisher.none.fl_str_mv Massachusetts Medical Society
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