Zika virus infection in pregnant women in Rio de Janeiro: preliminary report
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/13063 |
Resumo: | Artigo liberado em acesso aberto como parte do acordo para tornar público todos os dados produzidos sobre o vírus zika - Compartilhamento de dados em emergências de saúde pública - http://www.wellcome.ac.uk/News/Media-office/Press-releases/2016/WTP060169.htm |
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Brasil, PatríciaPereira, José P.Gabaglia, Claudia RajaDamasceno, LuanaWakimoto, MayumiNogueira, Rita M. RibeiroSequeira, Patrícia Carvalho deSiqueira, André MachadoCarvalho, Liege M. Abreu deCunha, Denise Cotrim daCalvet, Guilherme A.Neves, Elizabeth S.Moreira, Maria E.Baião, Ana E. RodriguesCarvalho, Paulo R. Nassar deJanzen, CarlaValderramos, Stephanie G.Cherry, James D.Filippis, Ana M. Bispo deNielsen-Saines, Karin2016-03-09T11:54:02Z2016-03-09T11:54:02Z2016BRASIL, Patrícia et al. Zika virus infection in pregnant women in Rio de Janeiro: preliminary report. The New England Journal of Medicine, Massachusetts, March 8, p. 1-11, 2016.0028-4793https://www.arca.fiocruz.br/handle/icict/1306310.1056/NEJMoa1602412Artigo liberado em acesso aberto como parte do acordo para tornar público todos os dados produzidos sobre o vírus zika - Compartilhamento de dados em emergências de saúde pública - http://www.wellcome.ac.uk/News/Media-office/Press-releases/2016/WTP060169.htmVersão final do artigo - handle https://www.arca.fiocruz.br/handle/icict/17780Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Biomedical Research Institute of Southern California. Oceanside, California, EUA.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.David Geffen UCLA School of Medicine, Los Angeles, EUA.David Geffen UCLA School of Medicine, Los Angeles, EUA.David Geffen UCLA School of Medicine, Los Angeles, EUA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.David Geffen UCLA School of Medicine, Los Angeles, EUA.BACKGROUND Zika virus (ZIKV) has been linked to neonatal microcephaly. To characterize the spectrum of ZIKV disease in pregnancy, we followed patients in Rio de Janeiro to describe clinical manifestations in mothers and repercussions of acute ZIKV infection in fetuses. METHODS We enrolled pregnant women in whom a rash had developed within the previous 5 days and tested blood and urine specimens for ZIKV by reverse-transcriptase–polymerasechain-reaction assays. We followed the women prospectively and collected clinical and ultrasonographic data. RESULTS A total of 88 women were enrolled from September 2015 through February 2016; of these 88 women, 72 (82%) tested positive for ZIKV in blood, urine, or both. The timing of acute ZIKV infection ranged from 5 to 38 weeks of gestation. Predominant clinical features included pruritic descending macular or maculopapular rash, arthralgias, conjunctival injection, and headache; 28% had fever (short-term and low-grade).Women who were positive for ZIKV were more likely than those who were negative for the virus to have maculopapular rash (44% vs. 12%, P=0.02), conjunctival involvement (58% vs. 13%, P=0.002), and lymphadenopathy (40% vs. 7%, P=0.02). Fetal ultrasonography was performed in 42 ZIKV-positive women (58%) and in all ZIKV-negative women. Fetal abnormalities were detected by Doppler ultrasonography in 12 of the 42 ZIKV-positive women (29%) and in none of the 16 ZIKV-negative women. Adverse findings included fetal deaths at 36 and 38 weeks of gestation (2 fetuses), in utero growth restriction with or without microcephaly (5 fetuses), ventricular calcifications or other central nervous system (CNS) lesions (7 fetuses), and abnormal amniotic fluid volume or cerebral or umbilical artery flow (7 fetuses). To date, 8 of the 42 women in whom fetal ultrasonography was performed have delivered their babies, and the ultrasonographic findings have been confirmed. CONCLUSIONS Despite mild clinical symptoms, ZIKV infection during pregnancy appears to be associated with grave outcomes, including fetal death, placental insufficiency, fetal growth restriction, and CNS injury.porMassachusetts Medical SocietyVírus ZikaMicrocefaliaDoença ZIKV na gravidezAedes aegyptiZika VirusMicrocephalyZIKV disease in pregnancyAedes aegyptiAedesMicrocefaliaZika virus infection in pregnant women in Rio de Janeiro: preliminary reportinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13063/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALZika Virus Infection in Pregnant Women - preliminary report.pdfZika Virus Infection in Pregnant Women - preliminary report.pdfapplication/pdf646105https://www.arca.fiocruz.br/bitstream/icict/13063/2/Zika%20Virus%20Infection%20in%20Pregnant%20Women%20-%20preliminary%20report.pdf76b9427d455f2a5cbb1aa17b53e4cfc6MD52TEXTZika Virus Infection in Pregnant Women - 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dc.title.pt_BR.fl_str_mv |
Zika virus infection in pregnant women in Rio de Janeiro: preliminary report |
title |
Zika virus infection in pregnant women in Rio de Janeiro: preliminary report |
spellingShingle |
Zika virus infection in pregnant women in Rio de Janeiro: preliminary report Brasil, Patrícia Vírus Zika Microcefalia Doença ZIKV na gravidez Aedes aegypti Zika Virus Microcephaly ZIKV disease in pregnancy Aedes aegypti Aedes Microcefalia |
title_short |
Zika virus infection in pregnant women in Rio de Janeiro: preliminary report |
title_full |
Zika virus infection in pregnant women in Rio de Janeiro: preliminary report |
title_fullStr |
Zika virus infection in pregnant women in Rio de Janeiro: preliminary report |
title_full_unstemmed |
Zika virus infection in pregnant women in Rio de Janeiro: preliminary report |
title_sort |
Zika virus infection in pregnant women in Rio de Janeiro: preliminary report |
author |
Brasil, Patrícia |
author_facet |
Brasil, Patrícia Pereira, José P. Gabaglia, Claudia Raja Damasceno, Luana Wakimoto, Mayumi Nogueira, Rita M. Ribeiro Sequeira, Patrícia Carvalho de Siqueira, André Machado Carvalho, Liege M. Abreu de Cunha, Denise Cotrim da Calvet, Guilherme A. Neves, Elizabeth S. Moreira, Maria E. Baião, Ana E. Rodrigues Carvalho, Paulo R. Nassar de Janzen, Carla Valderramos, Stephanie G. Cherry, James D. Filippis, Ana M. Bispo de Nielsen-Saines, Karin |
author_role |
author |
author2 |
Pereira, José P. Gabaglia, Claudia Raja Damasceno, Luana Wakimoto, Mayumi Nogueira, Rita M. Ribeiro Sequeira, Patrícia Carvalho de Siqueira, André Machado Carvalho, Liege M. Abreu de Cunha, Denise Cotrim da Calvet, Guilherme A. Neves, Elizabeth S. Moreira, Maria E. Baião, Ana E. Rodrigues Carvalho, Paulo R. Nassar de Janzen, Carla Valderramos, Stephanie G. Cherry, James D. Filippis, Ana M. Bispo de Nielsen-Saines, Karin |
author2_role |
author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Brasil, Patrícia Pereira, José P. Gabaglia, Claudia Raja Damasceno, Luana Wakimoto, Mayumi Nogueira, Rita M. Ribeiro Sequeira, Patrícia Carvalho de Siqueira, André Machado Carvalho, Liege M. Abreu de Cunha, Denise Cotrim da Calvet, Guilherme A. Neves, Elizabeth S. Moreira, Maria E. Baião, Ana E. Rodrigues Carvalho, Paulo R. Nassar de Janzen, Carla Valderramos, Stephanie G. Cherry, James D. Filippis, Ana M. Bispo de Nielsen-Saines, Karin |
dc.subject.other.pt_BR.fl_str_mv |
Vírus Zika Microcefalia Doença ZIKV na gravidez Aedes aegypti |
topic |
Vírus Zika Microcefalia Doença ZIKV na gravidez Aedes aegypti Zika Virus Microcephaly ZIKV disease in pregnancy Aedes aegypti Aedes Microcefalia |
dc.subject.en.pt_BR.fl_str_mv |
Zika Virus |
dc.subject.en.none.fl_str_mv |
Microcephaly ZIKV disease in pregnancy Aedes aegypti |
dc.subject.decs.pt_BR.fl_str_mv |
Aedes Microcefalia |
description |
Artigo liberado em acesso aberto como parte do acordo para tornar público todos os dados produzidos sobre o vírus zika - Compartilhamento de dados em emergências de saúde pública - http://www.wellcome.ac.uk/News/Media-office/Press-releases/2016/WTP060169.htm |
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2016 |
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2016-03-09T11:54:02Z |
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2016-03-09T11:54:02Z |
dc.date.issued.fl_str_mv |
2016 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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dc.identifier.citation.fl_str_mv |
BRASIL, Patrícia et al. Zika virus infection in pregnant women in Rio de Janeiro: preliminary report. The New England Journal of Medicine, Massachusetts, March 8, p. 1-11, 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/13063 |
dc.identifier.issn.none.fl_str_mv |
0028-4793 |
dc.identifier.doi.none.fl_str_mv |
10.1056/NEJMoa1602412 |
identifier_str_mv |
BRASIL, Patrícia et al. Zika virus infection in pregnant women in Rio de Janeiro: preliminary report. The New England Journal of Medicine, Massachusetts, March 8, p. 1-11, 2016. 0028-4793 10.1056/NEJMoa1602412 |
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https://www.arca.fiocruz.br/handle/icict/13063 |
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Massachusetts Medical Society |
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Massachusetts Medical Society |
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