Description of leprosy classification at baseline among patients enrolled at the uniform multidrug therapy clinical trial for leprosy patients in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/41306 |
Resumo: | Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. |
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Moura, Rodrigo ScaliantePenna, Gerson OliveiraCardoso, Ludimila Paula VazPontes, Maria Araci de AndradeCruz, RossileneGonçalves, Heitor de SáPenna, Maria Lucia FernandesStefani, Mariane Martins de AraújoBührer-Sékula, Samira2020-05-19T17:08:43Z2020-05-19T17:08:43Z2015MOURA, Rodrigo Scaliante et al. Description of Leprosy classification at baseline among patients enrolled at the uniform multidrug therapy clinical trial for Leprosy patients in Brazil. American Journal of Tropical Medicine and Hygine, [Bethesda], v. 92, n. 6, p. 1280–1284, 2016.0002-9637https://www.arca.fiocruz.br/handle/icict/4130610.4269/ajtmh.14-0049Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Universidade de Brasília. Faculdade de Medicina. Núcleo de Medicina Tropical. Brasília, DF, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Centro de Dermatologia Dona Libânia, Fortaleza, CE, Brasil.Centro de Dermatologia Dona Libânia, Fortaleza, CE, Brasil.Fundação de Dermatologia e Venereologia Tropical Alfredo da Matta. Manaus, AM, Brasil.Universidade Federal Fluminense. Departamento de Epidemiologia e Bioestatística. Niterói, RJ, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.The uniform multidrug therapy clinical trial, Brazil (U-MDT/CT-BR), database was used to describe and report the performance of available tools to classify 830 leprosy patients as paucibacillary (PB) and multibacillary (MB) at baseline. In a modified Ridley and Jopling (R&J) classification, considering clinical features, histopathological results of skin biopsies and the slit-skin smear bacterial load results were used as the gold standard method for classification. Anti-phenolic glycolipid-I (PGL-I) serology by ML Flow test, the slit skin smear bacterial load, and the number of skin lesions were evaluated. Considering the R&J classification system as gold standard, ML Flow tests correctly allocated 70% patients in the PB group and 87% in the MB group. The classification based on counting the number of skin lesions correctly allocated 46% PB patients and 99% MB leprosy cases. Slit skin smears properly classified 91% and 97% of PB and MB patients, respectively. Based on U-MDT/CT-BR results, classification of leprosy patients for treatment purposes is unnecessary because it does not impact clinical and laboratories outcomes. In this context, the identification of new biomarkers to detect patients at a higher risk to develop leprosy reactions or relapse remains an important research challenge.engThe American Society of Tropical Medicine and HygieneCross-Sectional StudiesLeprostatic AgentsLeprosyLeprosy, MultibacillaryLeprosy, PaucibacillaryLeprosy / pathologyLeprosy / drug therapyLeprosyMultidrug therapyMycobacterium lepraeU-MDT/CT-BRHanseníaseTratamento FarmacológicoMycobacterium lepraeDiagnósticoDescription of leprosy classification at baseline among patients enrolled at the uniform multidrug therapy clinical trial for leprosy patients in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Description of leprosy classification at baseline among patients enrolled at the uniform multidrug therapy clinical trial for leprosy patients in Brazil |
| title |
Description of leprosy classification at baseline among patients enrolled at the uniform multidrug therapy clinical trial for leprosy patients in Brazil |
| spellingShingle |
Description of leprosy classification at baseline among patients enrolled at the uniform multidrug therapy clinical trial for leprosy patients in Brazil Moura, Rodrigo Scaliante Cross-Sectional Studies Leprostatic Agents Leprosy Leprosy, Multibacillary Leprosy, Paucibacillary Leprosy / pathology Leprosy / drug therapy Leprosy Multidrug therapy Mycobacterium leprae U-MDT/CT-BR Hanseníase Tratamento Farmacológico Mycobacterium leprae Diagnóstico |
| title_short |
Description of leprosy classification at baseline among patients enrolled at the uniform multidrug therapy clinical trial for leprosy patients in Brazil |
| title_full |
Description of leprosy classification at baseline among patients enrolled at the uniform multidrug therapy clinical trial for leprosy patients in Brazil |
| title_fullStr |
Description of leprosy classification at baseline among patients enrolled at the uniform multidrug therapy clinical trial for leprosy patients in Brazil |
| title_full_unstemmed |
Description of leprosy classification at baseline among patients enrolled at the uniform multidrug therapy clinical trial for leprosy patients in Brazil |
| title_sort |
Description of leprosy classification at baseline among patients enrolled at the uniform multidrug therapy clinical trial for leprosy patients in Brazil |
| author |
Moura, Rodrigo Scaliante |
| author_facet |
Moura, Rodrigo Scaliante Penna, Gerson Oliveira Cardoso, Ludimila Paula Vaz Pontes, Maria Araci de Andrade Cruz, Rossilene Gonçalves, Heitor de Sá Penna, Maria Lucia Fernandes Stefani, Mariane Martins de Araújo Bührer-Sékula, Samira |
| author_role |
author |
| author2 |
Penna, Gerson Oliveira Cardoso, Ludimila Paula Vaz Pontes, Maria Araci de Andrade Cruz, Rossilene Gonçalves, Heitor de Sá Penna, Maria Lucia Fernandes Stefani, Mariane Martins de Araújo Bührer-Sékula, Samira |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Moura, Rodrigo Scaliante Penna, Gerson Oliveira Cardoso, Ludimila Paula Vaz Pontes, Maria Araci de Andrade Cruz, Rossilene Gonçalves, Heitor de Sá Penna, Maria Lucia Fernandes Stefani, Mariane Martins de Araújo Bührer-Sékula, Samira |
| dc.subject.mesh.pt_BR.fl_str_mv |
Cross-Sectional Studies Leprostatic Agents Leprosy Leprosy, Multibacillary Leprosy, Paucibacillary Leprosy / pathology Leprosy / drug therapy |
| topic |
Cross-Sectional Studies Leprostatic Agents Leprosy Leprosy, Multibacillary Leprosy, Paucibacillary Leprosy / pathology Leprosy / drug therapy Leprosy Multidrug therapy Mycobacterium leprae U-MDT/CT-BR Hanseníase Tratamento Farmacológico Mycobacterium leprae Diagnóstico |
| dc.subject.en.pt_BR.fl_str_mv |
Leprosy Multidrug therapy Mycobacterium leprae U-MDT/CT-BR |
| dc.subject.decs.pt_BR.fl_str_mv |
Hanseníase Tratamento Farmacológico Mycobacterium leprae Diagnóstico |
| description |
Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. |
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2015 |
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2015 |
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2020-05-19T17:08:43Z |
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2020-05-19T17:08:43Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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MOURA, Rodrigo Scaliante et al. Description of Leprosy classification at baseline among patients enrolled at the uniform multidrug therapy clinical trial for Leprosy patients in Brazil. American Journal of Tropical Medicine and Hygine, [Bethesda], v. 92, n. 6, p. 1280–1284, 2016. |
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https://www.arca.fiocruz.br/handle/icict/41306 |
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0002-9637 |
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10.4269/ajtmh.14-0049 |
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MOURA, Rodrigo Scaliante et al. Description of Leprosy classification at baseline among patients enrolled at the uniform multidrug therapy clinical trial for Leprosy patients in Brazil. American Journal of Tropical Medicine and Hygine, [Bethesda], v. 92, n. 6, p. 1280–1284, 2016. 0002-9637 10.4269/ajtmh.14-0049 |
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eng |
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The American Society of Tropical Medicine and Hygiene |
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The American Society of Tropical Medicine and Hygiene |
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