Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/41338 |
Resumo: | Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. |
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Gonçalves, Heitor de SáPontes, Maria Araci de AndradeBührer-Sékula, SamiraCruz, RossileneAlmeida, Paulo CesarMoraes, Maria Elisabete Amaral dePenna, Gerson Oliveira2020-05-21T13:16:52Z2020-05-21T13:16:52Z2012GONCALVES, Heitor de Sá et al . Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, p. 74-78, dec. 2012. Supl. 1.0074-0276https://www.arca.fiocruz.br/handle/icict/4133810.1590/s0074-02762012000900013Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.Colaboradores: Marcelo Távora Mira (PUC-Paraná); Dra. Maria Lúcia Fernandes Penna (UFF) e Dra. Sinésio Talhari (UNL-AM).DECIT-MS/CNPqCentro de Dermatologia Dona Libânia. Fortaleza, CE, Brasil.Centro de Dermatologia Dona Libânia. Fortaleza, CE, Brasil.Universidade Federal de Goiás. Goiânia, GO, Brasil.Fundação Alfredo da Matta. Manaus, AM, Brasil.Universidade Estadual do Ceará. Fortaleza, CE, Brasil.Universidade Federal do Ceará. Fortaleza, CE, Brasil.Universidade de Brasília. Faculdade de Medicina. Núcleo de Medicina Tropical. Brasília, DF, Brasil.This study sought to verify the correlation between leprosy types and the adverse effects of treatment drugs. This quantitative, prospective, nested study was developed at the Dona Libânia Dermatology Centre in Fortaleza, Brazil. Data were collected from November 2007-November 2008. During this period, 818 leprosy patients were diagnosed and began treatment. Forty patients with tuberculoid leprosy (TT) were selected. Twenty patients followed a standard therapy of dapsone and rifampicin and 20 were administered dapsone, rifampicin and clofazimine (U-MDT). Twenty patients with borderline lepromatous (BL) and lepromatous leprosy (LL) were also selected and treated with U-MDT. All of the subjects received six doses. With the exception of haemolytic anaemia, there was a low incidence of adverse effects in all the groups. We did not observe any differences in the incidence of haemolytic anaemia or other side effects across groups of patients with TT, BL or LL treated with U-MDT.engInstituto Oswaldo CruzClofazimineDapsoneDrug Therapy, CombinationLeprostatic AgentsLeprosy, LepromatousLeprosy, MultibacillaryLeprosy, TuberculoidProspective StudiesRifampinLeprosyMultibacillary leprosyPaucibacillary leprosyAdverse effectsTherapeuticsLeprostatic agentsHanseníaseMycobacterium lepraeHansenostáticosDoenças TransmissíveisProgressão da DoençaHanseníase MultibacilarHanseníase PaucibacilarBrazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effectsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects |
title |
Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects |
spellingShingle |
Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects Gonçalves, Heitor de Sá Clofazimine Dapsone Drug Therapy, Combination Leprostatic Agents Leprosy, Lepromatous Leprosy, Multibacillary Leprosy, Tuberculoid Prospective Studies Rifampin Leprosy Multibacillary leprosy Paucibacillary leprosy Adverse effects Therapeutics Leprostatic agents Hanseníase Mycobacterium leprae Hansenostáticos Doenças Transmissíveis Progressão da Doença Hanseníase Multibacilar Hanseníase Paucibacilar |
title_short |
Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects |
title_full |
Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects |
title_fullStr |
Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects |
title_full_unstemmed |
Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects |
title_sort |
Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects |
author |
Gonçalves, Heitor de Sá |
author_facet |
Gonçalves, Heitor de Sá Pontes, Maria Araci de Andrade Bührer-Sékula, Samira Cruz, Rossilene Almeida, Paulo Cesar Moraes, Maria Elisabete Amaral de Penna, Gerson Oliveira |
author_role |
author |
author2 |
Pontes, Maria Araci de Andrade Bührer-Sékula, Samira Cruz, Rossilene Almeida, Paulo Cesar Moraes, Maria Elisabete Amaral de Penna, Gerson Oliveira |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Gonçalves, Heitor de Sá Pontes, Maria Araci de Andrade Bührer-Sékula, Samira Cruz, Rossilene Almeida, Paulo Cesar Moraes, Maria Elisabete Amaral de Penna, Gerson Oliveira |
dc.subject.mesh.pt_BR.fl_str_mv |
Clofazimine Dapsone Drug Therapy, Combination Leprostatic Agents Leprosy, Lepromatous Leprosy, Multibacillary Leprosy, Tuberculoid Prospective Studies Rifampin |
topic |
Clofazimine Dapsone Drug Therapy, Combination Leprostatic Agents Leprosy, Lepromatous Leprosy, Multibacillary Leprosy, Tuberculoid Prospective Studies Rifampin Leprosy Multibacillary leprosy Paucibacillary leprosy Adverse effects Therapeutics Leprostatic agents Hanseníase Mycobacterium leprae Hansenostáticos Doenças Transmissíveis Progressão da Doença Hanseníase Multibacilar Hanseníase Paucibacilar |
dc.subject.en.pt_BR.fl_str_mv |
Leprosy Multibacillary leprosy Paucibacillary leprosy Adverse effects Therapeutics Leprostatic agents |
dc.subject.decs.pt_BR.fl_str_mv |
Hanseníase Mycobacterium leprae Hansenostáticos Doenças Transmissíveis Progressão da Doença Hanseníase Multibacilar Hanseníase Paucibacilar |
description |
Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2020-05-21T13:16:52Z |
dc.date.available.fl_str_mv |
2020-05-21T13:16:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GONCALVES, Heitor de Sá et al . Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, p. 74-78, dec. 2012. Supl. 1. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/41338 |
dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
dc.identifier.doi.none.fl_str_mv |
10.1590/s0074-02762012000900013 |
identifier_str_mv |
GONCALVES, Heitor de Sá et al . Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, p. 74-78, dec. 2012. Supl. 1. 0074-0276 10.1590/s0074-02762012000900013 |
url |
https://www.arca.fiocruz.br/handle/icict/41338 |
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eng |
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eng |
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Instituto Oswaldo Cruz |
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Instituto Oswaldo Cruz |
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