Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects

Detalhes bibliográficos
Autor(a) principal: Gonçalves, Heitor de Sá
Data de Publicação: 2012
Outros Autores: Pontes, Maria Araci de Andrade, Bührer-Sékula, Samira, Cruz, Rossilene, Almeida, Paulo Cesar, Moraes, Maria Elisabete Amaral de, Penna, Gerson Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41338
Resumo: Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.
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spelling Gonçalves, Heitor de SáPontes, Maria Araci de AndradeBührer-Sékula, SamiraCruz, RossileneAlmeida, Paulo CesarMoraes, Maria Elisabete Amaral dePenna, Gerson Oliveira2020-05-21T13:16:52Z2020-05-21T13:16:52Z2012GONCALVES, Heitor de Sá et al . Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, p. 74-78, dec. 2012. Supl. 1.0074-0276https://www.arca.fiocruz.br/handle/icict/4133810.1590/s0074-02762012000900013Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.Colaboradores: Marcelo Távora Mira (PUC-Paraná); Dra. Maria Lúcia Fernandes Penna (UFF) e Dra. Sinésio Talhari (UNL-AM).DECIT-MS/CNPqCentro de Dermatologia Dona Libânia. Fortaleza, CE, Brasil.Centro de Dermatologia Dona Libânia. Fortaleza, CE, Brasil.Universidade Federal de Goiás. Goiânia, GO, Brasil.Fundação Alfredo da Matta. Manaus, AM, Brasil.Universidade Estadual do Ceará. Fortaleza, CE, Brasil.Universidade Federal do Ceará. Fortaleza, CE, Brasil.Universidade de Brasília. Faculdade de Medicina. Núcleo de Medicina Tropical. Brasília, DF, Brasil.This study sought to verify the correlation between leprosy types and the adverse effects of treatment drugs. This quantitative, prospective, nested study was developed at the Dona Libânia Dermatology Centre in Fortaleza, Brazil. Data were collected from November 2007-November 2008. During this period, 818 leprosy patients were diagnosed and began treatment. Forty patients with tuberculoid leprosy (TT) were selected. Twenty patients followed a standard therapy of dapsone and rifampicin and 20 were administered dapsone, rifampicin and clofazimine (U-MDT). Twenty patients with borderline lepromatous (BL) and lepromatous leprosy (LL) were also selected and treated with U-MDT. All of the subjects received six doses. With the exception of haemolytic anaemia, there was a low incidence of adverse effects in all the groups. We did not observe any differences in the incidence of haemolytic anaemia or other side effects across groups of patients with TT, BL or LL treated with U-MDT.engInstituto Oswaldo CruzClofazimineDapsoneDrug Therapy, CombinationLeprostatic AgentsLeprosy, LepromatousLeprosy, MultibacillaryLeprosy, TuberculoidProspective StudiesRifampinLeprosyMultibacillary leprosyPaucibacillary leprosyAdverse effectsTherapeuticsLeprostatic agentsHanseníaseMycobacterium lepraeHansenostáticosDoenças TransmissíveisProgressão da DoençaHanseníase MultibacilarHanseníase PaucibacilarBrazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effectsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects
title Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects
spellingShingle Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects
Gonçalves, Heitor de Sá
Clofazimine
Dapsone
Drug Therapy, Combination
Leprostatic Agents
Leprosy, Lepromatous
Leprosy, Multibacillary
Leprosy, Tuberculoid
Prospective Studies
Rifampin
Leprosy
Multibacillary leprosy
Paucibacillary leprosy
Adverse effects
Therapeutics
Leprostatic agents
Hanseníase
Mycobacterium leprae
Hansenostáticos
Doenças Transmissíveis
Progressão da Doença
Hanseníase Multibacilar
Hanseníase Paucibacilar
title_short Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects
title_full Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects
title_fullStr Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects
title_full_unstemmed Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects
title_sort Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects
author Gonçalves, Heitor de Sá
author_facet Gonçalves, Heitor de Sá
Pontes, Maria Araci de Andrade
Bührer-Sékula, Samira
Cruz, Rossilene
Almeida, Paulo Cesar
Moraes, Maria Elisabete Amaral de
Penna, Gerson Oliveira
author_role author
author2 Pontes, Maria Araci de Andrade
Bührer-Sékula, Samira
Cruz, Rossilene
Almeida, Paulo Cesar
Moraes, Maria Elisabete Amaral de
Penna, Gerson Oliveira
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gonçalves, Heitor de Sá
Pontes, Maria Araci de Andrade
Bührer-Sékula, Samira
Cruz, Rossilene
Almeida, Paulo Cesar
Moraes, Maria Elisabete Amaral de
Penna, Gerson Oliveira
dc.subject.mesh.pt_BR.fl_str_mv Clofazimine
Dapsone
Drug Therapy, Combination
Leprostatic Agents
Leprosy, Lepromatous
Leprosy, Multibacillary
Leprosy, Tuberculoid
Prospective Studies
Rifampin
topic Clofazimine
Dapsone
Drug Therapy, Combination
Leprostatic Agents
Leprosy, Lepromatous
Leprosy, Multibacillary
Leprosy, Tuberculoid
Prospective Studies
Rifampin
Leprosy
Multibacillary leprosy
Paucibacillary leprosy
Adverse effects
Therapeutics
Leprostatic agents
Hanseníase
Mycobacterium leprae
Hansenostáticos
Doenças Transmissíveis
Progressão da Doença
Hanseníase Multibacilar
Hanseníase Paucibacilar
dc.subject.en.pt_BR.fl_str_mv Leprosy
Multibacillary leprosy
Paucibacillary leprosy
Adverse effects
Therapeutics
Leprostatic agents
dc.subject.decs.pt_BR.fl_str_mv Hanseníase
Mycobacterium leprae
Hansenostáticos
Doenças Transmissíveis
Progressão da Doença
Hanseníase Multibacilar
Hanseníase Paucibacilar
description Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2020-05-21T13:16:52Z
dc.date.available.fl_str_mv 2020-05-21T13:16:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GONCALVES, Heitor de Sá et al . Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, p. 74-78, dec. 2012. Supl. 1.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41338
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/s0074-02762012000900013
identifier_str_mv GONCALVES, Heitor de Sá et al . Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, p. 74-78, dec. 2012. Supl. 1.
0074-0276
10.1590/s0074-02762012000900013
url https://www.arca.fiocruz.br/handle/icict/41338
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz
publisher.none.fl_str_mv Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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