The occurrence of histoplasmosis in Brazil: a systematic review

Detalhes bibliográficos
Autor(a) principal: Almeida, Marcos de Abreu
Data de Publicação: 2019
Outros Autores: Almeida-Silva, Fernando, Guimarães, Allan Jefferson, Almeida-Paes, Rodrigo, Zancopé-Oliveira, Rosely Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35516
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
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spelling Almeida, Marcos de AbreuAlmeida-Silva, FernandoGuimarães, Allan JeffersonAlmeida-Paes, RodrigoZancopé-Oliveira, Rosely Maria2019-09-12T12:39:00Z2019-09-12T12:39:00Z2019ALMEIDA, Marcos de Abreu et al. The occurrence of histoplasmosis in Brazil: a systematic review. International Journal of Infectious Diseases, v. 86, 147-156, 2019.1201-9712https://www.arca.fiocruz.br/handle/icict/3551610.1016/j.ijid.2019.07.0091878-3511engElsevierThe occurrence of histoplasmosis in Brazil: a systematic reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Background: Histoplasmosis is a systemic disease caused by the dimorphic fungus Histoplasma capsulatum. Diagnosis is often delayed, or it is misdiagnosed as tuberculosis. In Brazil, the infection is common and cases of histoplasmosis have been described in all regions of the country; however, the real problem is underestimated since notification of histoplasmosis is not mandatory. Methods: Human histoplasmosis cases diagnosed in Brazil and published up to December 2018 were identified through a search conducted in the PubMed/MEDLINE, SciELO, and Web of Science databases. Moreover, the isolation of H. capsulatum from animals or environmental sources in Brazil was also evaluated. Results: A total of 207 articles fulfilled the inclusion criteria and were evaluated, involving a total of 3530 patients with a diagnosis of histoplasmosis during the period studied. Of these patients, 78.3% were male, giving a male-to-female ratio of approximately 4:1. Histoplasmosis presented a higher frequency in individuals between the fourth and fifth decades of life. Disseminated disease was the most common form of histoplasmosis. Isolation of H. capsulatum on culture media and histopathology using staining methods were the diagnostic methods with the best efficiency. The best results in the identification of the H. capsulatum were achieved for samples from mononuclear phagocyte system components, skin and mucosa, and hematological samples. Regarding predisposing factors for histoplasmosis, HIV infection was the most common underlying condition. The overall mortality rate was 33.1%. Conclusions: This study represents the first available systematic review demonstrating Brazilian cases of histoplasmosis in the literature and highlights that the disease is more widespread in the Brazilian territory than has previously been thought.HistoplasmosisDiagnosisEpidemiologySystematic reviewBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/35516/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Almeida_Marcos_etal_INI_2019.pdfve_Almeida_Marcos_etal_INI_2019.pdfapplication/pdf1774758https://www.arca.fiocruz.br/bitstream/icict/35516/2/ve_Almeida_Marcos_etal_INI_2019.pdf8487511912a9f4f5418469412c7a80dcMD52TEXTve_Almeida_Marcos_etal_INI_2019.pdf.txtve_Almeida_Marcos_etal_INI_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The occurrence of histoplasmosis in Brazil: a systematic review
title The occurrence of histoplasmosis in Brazil: a systematic review
spellingShingle The occurrence of histoplasmosis in Brazil: a systematic review
Almeida, Marcos de Abreu
Histoplasmosis
Diagnosis
Epidemiology
Systematic review
Brazil
title_short The occurrence of histoplasmosis in Brazil: a systematic review
title_full The occurrence of histoplasmosis in Brazil: a systematic review
title_fullStr The occurrence of histoplasmosis in Brazil: a systematic review
title_full_unstemmed The occurrence of histoplasmosis in Brazil: a systematic review
title_sort The occurrence of histoplasmosis in Brazil: a systematic review
author Almeida, Marcos de Abreu
author_facet Almeida, Marcos de Abreu
Almeida-Silva, Fernando
Guimarães, Allan Jefferson
Almeida-Paes, Rodrigo
Zancopé-Oliveira, Rosely Maria
author_role author
author2 Almeida-Silva, Fernando
Guimarães, Allan Jefferson
Almeida-Paes, Rodrigo
Zancopé-Oliveira, Rosely Maria
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Marcos de Abreu
Almeida-Silva, Fernando
Guimarães, Allan Jefferson
Almeida-Paes, Rodrigo
Zancopé-Oliveira, Rosely Maria
dc.subject.en.pt_BR.fl_str_mv Histoplasmosis
Diagnosis
Epidemiology
Systematic review
Brazil
topic Histoplasmosis
Diagnosis
Epidemiology
Systematic review
Brazil
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-09-12T12:39:00Z
dc.date.available.fl_str_mv 2019-09-12T12:39:00Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALMEIDA, Marcos de Abreu et al. The occurrence of histoplasmosis in Brazil: a systematic review. International Journal of Infectious Diseases, v. 86, 147-156, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35516
dc.identifier.issn.pt_BR.fl_str_mv 1201-9712
dc.identifier.doi.none.fl_str_mv 10.1016/j.ijid.2019.07.009
dc.identifier.eissn.none.fl_str_mv 1878-3511
identifier_str_mv ALMEIDA, Marcos de Abreu et al. The occurrence of histoplasmosis in Brazil: a systematic review. International Journal of Infectious Diseases, v. 86, 147-156, 2019.
1201-9712
10.1016/j.ijid.2019.07.009
1878-3511
url https://www.arca.fiocruz.br/handle/icict/35516
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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