Direct intracardiac injection of umbilical cord-derived stromal cells and umbilical cord blood-derived endothelial cells for the treatment of ischemic cardiomyopathy
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15682 |
Resumo: | This work was supported by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (CT-Saúde/MS/SCTIE/DECIT/MCT/CNPq N 17/2008) and Fundação Araucária (Convênio no. 416/2009). |
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Suss, Paula HansenCapriglione, Luiz GuilhermeBarchiki, FabianeMiyague, LyeJackowski, DanielleFracaro, LetíciaSchittini, Andressa V.Senegaglia, Alexandra CristinaRebelatto, Carmen Lúcia KuniyoshiOlandoski, MarciaDominguez, Alejandro CorreaBrofman, Paulo Roberto Slud2016-09-05T18:16:00Z2016-09-05T18:16:00Z2015SUSS, Paula Hansen et al. Direct intracardiac injection of umbilical cord-derived stromal cells and umbilical cord blood-derived endothelial cells for the treatment of ischemic cardiomyopathy. Experimental Biology and Medicine, v. 240, n. 7, p. 969-978, 2015.1535-3702https://www.arca.fiocruz.br/handle/icict/1568210.1177/1535370214565077This work was supported by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (CT-Saúde/MS/SCTIE/DECIT/MCT/CNPq N 17/2008) and Fundação Araucária (Convênio no. 416/2009).Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.The development of new therapeutic strategies is necessary to reduce the worldwide social and economic impact of cardiovascular disease, which produces high rates of morbidity and mortality. A therapeutic option that has emerged in the last decade is cell therapy. The aim of this study was to compare the effect of transplanting human umbilical cord-derived stromal cells (UCSCs), human umbilical cord blood-derived endothelial cells (UCBECs) or a combination of these two cell types for the treatment of ischemic cardiomyopathy (IC) in a Wistar rat model. IC was induced by left coronary artery ligation, and baseline echocardiography was performed seven days later. Animals with a left ventricular ejection fraction (LVEF) of 40% were selected for the study. On the ninth day after IC was induced, the animals were randomized into the following experimental groups: UCSCs, UCBECs, UCSCs plus UCBECs, or vehicle (control). Thirty days after treatment, an echocardiographic analysis was performed, followed by euthanasia. The animals in all of the cell therapy groups, regardless of the cell type transplanted, had less collagen deposition in their heart tissue and demonstrated a significant improvement in myocardial function after IC. Furthermore, there was a trend of increasing numbers of blood vessels in the infarcted area. The median value of LVEF increased by 7.19% to 11.77%, whereas the control group decreased by 0.24%. These results suggest that UCSCs and UCBECs are promising cells for cellular cardiomyoplasty and can be an effective therapy for improving cardiac function following IC.porDirect intracardiac injection of umbilical cord-derived stromal cells and umbilical cord blood-derived endothelial cells for the treatment of ischemic cardiomyopathyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHuman umbilical cord-derived stromal cellsHuman umbilical cord blood-derived endothelial cellsCell therapyIschemic cardiomyopathyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15682/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSuss et al Direct intracardiac injection.pdfSuss et al Direct intracardiac injection.pdfapplication/pdf1458058https://www.arca.fiocruz.br/bitstream/icict/15682/2/Suss%20et%20al%20Direct%20intracardiac%20injection.pdff352b414b697cd29ce2061be68ee252bMD52TEXTSuss et al Direct intracardiac injection.pdf.txtSuss et al Direct intracardiac injection.pdf.txtExtracted texttext/plain43822https://www.arca.fiocruz.br/bitstream/icict/15682/3/Suss%20et%20al%20Direct%20intracardiac%20injection.pdf.txtb386ce0ef8d947030e7826082ca6bab5MD53icict/156822019-11-23 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dc.title.pt_BR.fl_str_mv |
Direct intracardiac injection of umbilical cord-derived stromal cells and umbilical cord blood-derived endothelial cells for the treatment of ischemic cardiomyopathy |
title |
Direct intracardiac injection of umbilical cord-derived stromal cells and umbilical cord blood-derived endothelial cells for the treatment of ischemic cardiomyopathy |
spellingShingle |
Direct intracardiac injection of umbilical cord-derived stromal cells and umbilical cord blood-derived endothelial cells for the treatment of ischemic cardiomyopathy Suss, Paula Hansen Human umbilical cord-derived stromal cells Human umbilical cord blood-derived endothelial cells Cell therapy Ischemic cardiomyopathy |
title_short |
Direct intracardiac injection of umbilical cord-derived stromal cells and umbilical cord blood-derived endothelial cells for the treatment of ischemic cardiomyopathy |
title_full |
Direct intracardiac injection of umbilical cord-derived stromal cells and umbilical cord blood-derived endothelial cells for the treatment of ischemic cardiomyopathy |
title_fullStr |
Direct intracardiac injection of umbilical cord-derived stromal cells and umbilical cord blood-derived endothelial cells for the treatment of ischemic cardiomyopathy |
title_full_unstemmed |
Direct intracardiac injection of umbilical cord-derived stromal cells and umbilical cord blood-derived endothelial cells for the treatment of ischemic cardiomyopathy |
title_sort |
Direct intracardiac injection of umbilical cord-derived stromal cells and umbilical cord blood-derived endothelial cells for the treatment of ischemic cardiomyopathy |
author |
Suss, Paula Hansen |
author_facet |
Suss, Paula Hansen Capriglione, Luiz Guilherme Barchiki, Fabiane Miyague, Lye Jackowski, Danielle Fracaro, Letícia Schittini, Andressa V. Senegaglia, Alexandra Cristina Rebelatto, Carmen Lúcia Kuniyoshi Olandoski, Marcia Dominguez, Alejandro Correa Brofman, Paulo Roberto Slud |
author_role |
author |
author2 |
Capriglione, Luiz Guilherme Barchiki, Fabiane Miyague, Lye Jackowski, Danielle Fracaro, Letícia Schittini, Andressa V. Senegaglia, Alexandra Cristina Rebelatto, Carmen Lúcia Kuniyoshi Olandoski, Marcia Dominguez, Alejandro Correa Brofman, Paulo Roberto Slud |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Suss, Paula Hansen Capriglione, Luiz Guilherme Barchiki, Fabiane Miyague, Lye Jackowski, Danielle Fracaro, Letícia Schittini, Andressa V. Senegaglia, Alexandra Cristina Rebelatto, Carmen Lúcia Kuniyoshi Olandoski, Marcia Dominguez, Alejandro Correa Brofman, Paulo Roberto Slud |
dc.subject.en.pt_BR.fl_str_mv |
Human umbilical cord-derived stromal cells Human umbilical cord blood-derived endothelial cells Cell therapy Ischemic cardiomyopathy |
topic |
Human umbilical cord-derived stromal cells Human umbilical cord blood-derived endothelial cells Cell therapy Ischemic cardiomyopathy |
description |
This work was supported by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (CT-Saúde/MS/SCTIE/DECIT/MCT/CNPq N 17/2008) and Fundação Araucária (Convênio no. 416/2009). |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2016-09-05T18:16:00Z |
dc.date.available.fl_str_mv |
2016-09-05T18:16:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SUSS, Paula Hansen et al. Direct intracardiac injection of umbilical cord-derived stromal cells and umbilical cord blood-derived endothelial cells for the treatment of ischemic cardiomyopathy. Experimental Biology and Medicine, v. 240, n. 7, p. 969-978, 2015. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/15682 |
dc.identifier.issn.pt_BR.fl_str_mv |
1535-3702 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1177/1535370214565077 |
identifier_str_mv |
SUSS, Paula Hansen et al. Direct intracardiac injection of umbilical cord-derived stromal cells and umbilical cord blood-derived endothelial cells for the treatment of ischemic cardiomyopathy. Experimental Biology and Medicine, v. 240, n. 7, p. 969-978, 2015. 1535-3702 10.1177/1535370214565077 |
url |
https://www.arca.fiocruz.br/handle/icict/15682 |
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