Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy

Detalhes bibliográficos
Autor(a) principal: Teles, Rosane M. B.
Data de Publicação: 2010
Outros Autores: Krutzik, Stephan R., Ochoa, Maria T., Oliveira, Rosane B., Sarno, Euzenir N., Modlin, Robert L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/22914
Resumo: University of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA.
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spelling Teles, Rosane M. B.Krutzik, Stephan R.Ochoa, Maria T.Oliveira, Rosane B.Sarno, Euzenir N.Modlin, Robert L.2017-10-24T11:08:25Z2017-10-24T11:08:25Z2010TELES, Rosane M. B. et al. Interleukin-4 Regulates the Expression of CD209 and Subsequent Uptake of Mycobacterium leprae by Schwann Cells in Human Leprosy. Infection and Immunity, v.78, n.11, p.4634-4643, Nov. 2010.0019-9567https://www.arca.fiocruz.br/handle/icict/2291410.1128/IAI.00454-10engAmerican Society for MicrobiologyHanseníaseMycobacterium lepraeCélulas de SchwannHumanosMycobacterium lepraeRegulates the Expression of CD209Schwann CellsHuman LeprosyInterleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA.University of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA.University of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA.University of Massachusetts Medical School. Division of Infectious Diseases and Immunology. Department of Medicine. Worcester, Massachussets, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.University of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA / University of California Los Angeles. Department of Microbiology, Immunology and Molecular Genetics. Los Angeles, CA, USA.The ability of microbial pathogens to target specific cell types is a key aspect of the pathogenesis of infectious disease. Mycobacterium leprae, by infecting Schwann cells, contributes to nerve injury in patients with leprosy. Here, we investigated mechanisms of host-pathogen interaction in the peripheral nerve lesions of leprosy. We found that the expression of the C-type lectin, CD209, known to be expressed on tissue macrophages and to mediate the uptake of M. leprae, was present on Schwann cells, colocalizing with the Schwann cell marker, CNPase (2',3'-cyclic nucleotide 3'-phosphodiesterase), along with the M. leprae antigen PGL-1 in the peripheral nerve biopsy specimens. In vitro, human CD209-positive Schwann cells, both from primary cultures and a long-term line, have a higher binding of M. leprae compared to CD209-negative Schwann cells. Interleukin-4, known to be expressed in skin lesions from multibacillary patients, increased CD209 expression on human Schwann cells and subsequent Schwann cell binding to M. leprae, whereas Th1 cytokines did not induce CD209 expression on these cells. Therefore, the regulated expression of CD209 represents a common mechanism by which Schwann cells and macrophages bind and take up M. leprae, contributing to the pathogenesis of leprosy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/22914/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALeuzenir2_sarno_etal_IO_-2010.pdfeuzenir2_sarno_etal_IO_-2010.pdfapplication/pdf3243288https://www.arca.fiocruz.br/bitstream/icict/22914/2/euzenir2_sarno_etal_IO_-2010.pdf2163dfb644fcf0d20f8d9556bdf65d8fMD52TEXTeuzenir2_sarno_etal_IO_-2010.pdf.txteuzenir2_sarno_etal_IO_-2010.pdf.txtExtracted texttext/plain45798https://www.arca.fiocruz.br/bitstream/icict/22914/3/euzenir2_sarno_etal_IO_-2010.pdf.txt36be75d399c8c440af9822da4ccc0d13MD53icict/229142018-08-15 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dc.title.pt_BR.fl_str_mv Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy
title Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy
spellingShingle Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy
Teles, Rosane M. B.
Hanseníase
Mycobacterium leprae
Células de Schwann
Humanos
Mycobacterium leprae
Regulates the Expression of CD209
Schwann Cells
Human Leprosy
title_short Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy
title_full Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy
title_fullStr Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy
title_full_unstemmed Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy
title_sort Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy
author Teles, Rosane M. B.
author_facet Teles, Rosane M. B.
Krutzik, Stephan R.
Ochoa, Maria T.
Oliveira, Rosane B.
Sarno, Euzenir N.
Modlin, Robert L.
author_role author
author2 Krutzik, Stephan R.
Ochoa, Maria T.
Oliveira, Rosane B.
Sarno, Euzenir N.
Modlin, Robert L.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Teles, Rosane M. B.
Krutzik, Stephan R.
Ochoa, Maria T.
Oliveira, Rosane B.
Sarno, Euzenir N.
Modlin, Robert L.
dc.subject.other.pt_BR.fl_str_mv Hanseníase
Mycobacterium leprae
Células de Schwann
Humanos
topic Hanseníase
Mycobacterium leprae
Células de Schwann
Humanos
Mycobacterium leprae
Regulates the Expression of CD209
Schwann Cells
Human Leprosy
dc.subject.en.pt_BR.fl_str_mv Mycobacterium leprae
Regulates the Expression of CD209
Schwann Cells
Human Leprosy
description University of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2017-10-24T11:08:25Z
dc.date.available.fl_str_mv 2017-10-24T11:08:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TELES, Rosane M. B. et al. Interleukin-4 Regulates the Expression of CD209 and Subsequent Uptake of Mycobacterium leprae by Schwann Cells in Human Leprosy. Infection and Immunity, v.78, n.11, p.4634-4643, Nov. 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/22914
dc.identifier.issn.pt_BR.fl_str_mv 0019-9567
dc.identifier.doi.none.fl_str_mv 10.1128/IAI.00454-10
identifier_str_mv TELES, Rosane M. B. et al. Interleukin-4 Regulates the Expression of CD209 and Subsequent Uptake of Mycobacterium leprae by Schwann Cells in Human Leprosy. Infection and Immunity, v.78, n.11, p.4634-4643, Nov. 2010.
0019-9567
10.1128/IAI.00454-10
url https://www.arca.fiocruz.br/handle/icict/22914
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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