Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20976 |
Resumo: | Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil. |
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Silva, Sandra R. BoiçaTempone, Antônio J.Silva, Tatiana P.Costa, Maria Renata S. N.Pereira, Geraldo M. B.Lara, Flávio A.Pessolani, Maria Cristina V.Esquenazi, Danuza2017-09-12T16:52:26Z2017-09-12T16:52:26Z2010SILVA, Sandra R. Boiça; et al. Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts. Mem Inst Oswaldo Cruz, v.105, n.5, p.627-632, Aug. 2010.0074-0276https://www.arca.fiocruz.br/handle/icict/209761678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzMycobacterium lepraeHanseníaseCélulas de SchwannOsteoblastosMycobacterium lepraePHEXosteoblastsSchwann cellsMycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblastsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia. Rio de Janeiro, RJ. Brasil.Instituto Lauro de Souza Lima. Departamento de Saúde de São Paulo. Divisão de Ensino e Pesquisa. Bauru, SP, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia. Rio de Janeiro, RJ. Brasil.Neuropathy and bone deformities, lifelong sequelae of leprosy that persist after treatment, result in significant impairment to patients and compromise their social rehabilitation. Phosphate-regulating gene with homologies to endopeptidase on the X chromosome (PHEX) is a Zn-metalloendopeptidase, which is abundantly expressed in osteoblasts and many other cell types, such as Schwann cells, and has been implicated in phosphate metabolism and X-linked rickets. Here, we demonstrate that Mycobacterium leprae stimulation downregulates PHEX transcription and protein expression in a human schwannoma cell line (ST88-14) and human osteoblast lineage. Modulation of PHEX expression was observed to a lesser extent in cells stimulated with other species of mycobacteria, but was not observed in cultures treated with latex beads or with the facultative intracellular bacterium Salmonella typhimurium. Direct downregulation of PHEX by M. leprae could be involved in the bone resorption observed in leprosy patients. This is the first report to describe PHEX modulation by an infectious agent.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20976/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALantonio_tempone_etal_IOC_2010.pdfantonio_tempone_etal_IOC_2010.pdfapplication/pdf1038259https://www.arca.fiocruz.br/bitstream/icict/20976/2/antonio_tempone_etal_IOC_2010.pdf5263875cc94af291cb0b018474bcadebMD52TEXTantonio_tempone_etal_IOC_2010.pdf.txtantonio_tempone_etal_IOC_2010.pdf.txtExtracted texttext/plain33499https://www.arca.fiocruz.br/bitstream/icict/20976/3/antonio_tempone_etal_IOC_2010.pdf.txte70041fee01a55ceb7bce5c11549c5f2MD53icict/209762018-08-15 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| dc.title.pt_BR.fl_str_mv |
Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts |
| title |
Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts |
| spellingShingle |
Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts Silva, Sandra R. Boiça Mycobacterium leprae Hanseníase Células de Schwann Osteoblastos Mycobacterium leprae PHEX osteoblasts Schwann cells |
| title_short |
Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts |
| title_full |
Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts |
| title_fullStr |
Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts |
| title_full_unstemmed |
Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts |
| title_sort |
Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts |
| author |
Silva, Sandra R. Boiça |
| author_facet |
Silva, Sandra R. Boiça Tempone, Antônio J. Silva, Tatiana P. Costa, Maria Renata S. N. Pereira, Geraldo M. B. Lara, Flávio A. Pessolani, Maria Cristina V. Esquenazi, Danuza |
| author_role |
author |
| author2 |
Tempone, Antônio J. Silva, Tatiana P. Costa, Maria Renata S. N. Pereira, Geraldo M. B. Lara, Flávio A. Pessolani, Maria Cristina V. Esquenazi, Danuza |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Sandra R. Boiça Tempone, Antônio J. Silva, Tatiana P. Costa, Maria Renata S. N. Pereira, Geraldo M. B. Lara, Flávio A. Pessolani, Maria Cristina V. Esquenazi, Danuza |
| dc.subject.other.pt_BR.fl_str_mv |
Mycobacterium leprae Hanseníase Células de Schwann Osteoblastos |
| topic |
Mycobacterium leprae Hanseníase Células de Schwann Osteoblastos Mycobacterium leprae PHEX osteoblasts Schwann cells |
| dc.subject.en.pt_BR.fl_str_mv |
Mycobacterium leprae PHEX osteoblasts Schwann cells |
| description |
Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2010 |
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2010 |
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2017-09-12T16:52:26Z |
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2017-09-12T16:52:26Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
SILVA, Sandra R. Boiça; et al. Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts. Mem Inst Oswaldo Cruz, v.105, n.5, p.627-632, Aug. 2010. |
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https://www.arca.fiocruz.br/handle/icict/20976 |
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0074-0276 |
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1678-8060 |
| identifier_str_mv |
SILVA, Sandra R. Boiça; et al. Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts. Mem Inst Oswaldo Cruz, v.105, n.5, p.627-632, Aug. 2010. 0074-0276 1678-8060 |
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