Risk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIV-infected, antiretroviral-naïve patients

Detalhes bibliográficos
Autor(a) principal: Silva, Tatiana Pereira da
Data de Publicação: 2017
Outros Autores: Gripp, Carmem Beatriz Wagner Giacoia, Schmaltz, Carolina A., Sant'Anna, Flavia Marinho, Saad, Maria Helena, Matos, Juliana Arruda de, Silva, Julio Castro Alves de Lima e, Rolla, Valeria Cavalcanti, Morgado, Mariza Gonçalves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/24981
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
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spelling Silva, Tatiana Pereira daGripp, Carmem Beatriz Wagner GiacoiaSchmaltz, Carolina A.Sant'Anna, Flavia MarinhoSaad, Maria HelenaMatos, Juliana Arruda deSilva, Julio Castro Alves de Lima eRolla, Valeria CavalcantiMorgado, Mariza Gonçalves2018-02-27T16:42:30Z2018-02-27T16:42:30Z2017SILVA, Tatiana Pereira da et al. Risk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIVinfected, antiretroviral-naïve patients. BMC Infectious Diseases, v. 17, p. 1-10, 2017.1471-2334https://www.arca.fiocruz.br/handle/icict/2498110.1186/s12879-017-2700-6engBioMed CentralTuberculoseAIDSResposta imuneEnsaIo de Immunospot Ligado a EnzimasTuberculosisAIDSImmune responseELISpotIRISRisk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIV-infected, antiretroviral-naïve patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobactéria. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobactéria. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Imunização e Vigilância em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Plataforma de Pesquisa Clínica. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobactéria. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Background: Little is known regarding the restoration of the specific immune response after combined antiretroviral therapy (cART) and anti-tuberculosis (TB) therapy introduction among TB-HIV patients. In this study, we examined the immune response of TB-HIV patients to Mycobacterium tuberculosis (Mtb) antigens to evaluate the response dynamics to different antigens over time. Moreover, we also evaluated the influence of two different doses of efavirenz and the factors associated with immune reconstitution. Methods: This is a longitudinal study nested in a clinical trial, where cART was initiated during the baseline visit (D0), which occurred 30 ± 10 days after the introduction of anti-TB therapy. Follow-up visits were performed at 30, 60, 90 and 180 days after cART initiation. The production of IFN-γ upon in vitro stimulation with Mtb antigens purified protein derivative (PPD), ESAT-6 and 38 kDa/CFP-10 using ELISpot was examined at baseline and follow-up visits. Results: Sixty-one patients, all ART-naïve, were selected and included in the immune reconstitution analysis; seven (11.5%) developed Immune Reconstitution Inflammatory Syndrome (IRIS). The Mtb specific immune response was higher for the PPD antigen followed by 38 kDa/CFP-10 and increased in the first 60 days after cART initiation. In multivariate analysis, the variables independently associated with increased IFN-γ production in response to PPD antigen were CD4+ T cell counts <200 cells/mm3 at baseline, age, site of tuberculosis, 800 mg efavirenz dose and follow-up CD4+ T cell counts. Moreover, the factors associated with the production of IFN-γ in response to 38 kDa/ CFP-10 were detectable HIV viral load (VL) and CD4+ T cell counts at follow-up visits of ≥200 cells/mm3. Conclusions: These findings highlight the differences in immune response according to the specificity of the Mtb antigen, which contributes to a better understanding of TB-HIV immunopathogenesis. IFN-γ production elicited by PD and 38 kDa/CFP-10 antigens have a greater magnitude compared to ESAT-6 and are associated with different factors. The low response to ESAT-6, even during immune restoration, suggests that this antigen is not adequate to assess the immune response of immunosuppressed TB-HIV patients.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24981/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALcarmen_griep_etal_IOC-2017.pdfcarmen_griep_etal_IOC-2017.pdfapplication/pdf1072205https://www.arca.fiocruz.br/bitstream/icict/24981/2/carmen_griep_etal_IOC-2017.pdf8d456a42d18b43a3d9046f12490e18a7MD52TEXTcarmen_griep_etal_IOC-2017.pdf.txtcarmen_griep_etal_IOC-2017.pdf.txtExtracted texttext/plain42879https://www.arca.fiocruz.br/bitstream/icict/24981/3/carmen_griep_etal_IOC-2017.pdf.txt0719dca1c09b640a003d1cda164600d4MD53icict/249812019-08-06 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dc.title.pt_BR.fl_str_mv Risk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIV-infected, antiretroviral-naïve patients
title Risk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIV-infected, antiretroviral-naïve patients
spellingShingle Risk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIV-infected, antiretroviral-naïve patients
Silva, Tatiana Pereira da
Tuberculose
AIDS
Resposta imune
EnsaIo de Immunospot Ligado a Enzimas
Tuberculosis
AIDS
Immune response
ELISpot
IRIS
title_short Risk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIV-infected, antiretroviral-naïve patients
title_full Risk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIV-infected, antiretroviral-naïve patients
title_fullStr Risk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIV-infected, antiretroviral-naïve patients
title_full_unstemmed Risk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIV-infected, antiretroviral-naïve patients
title_sort Risk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIV-infected, antiretroviral-naïve patients
author Silva, Tatiana Pereira da
author_facet Silva, Tatiana Pereira da
Gripp, Carmem Beatriz Wagner Giacoia
Schmaltz, Carolina A.
Sant'Anna, Flavia Marinho
Saad, Maria Helena
Matos, Juliana Arruda de
Silva, Julio Castro Alves de Lima e
Rolla, Valeria Cavalcanti
Morgado, Mariza Gonçalves
author_role author
author2 Gripp, Carmem Beatriz Wagner Giacoia
Schmaltz, Carolina A.
Sant'Anna, Flavia Marinho
Saad, Maria Helena
Matos, Juliana Arruda de
Silva, Julio Castro Alves de Lima e
Rolla, Valeria Cavalcanti
Morgado, Mariza Gonçalves
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Tatiana Pereira da
Gripp, Carmem Beatriz Wagner Giacoia
Schmaltz, Carolina A.
Sant'Anna, Flavia Marinho
Saad, Maria Helena
Matos, Juliana Arruda de
Silva, Julio Castro Alves de Lima e
Rolla, Valeria Cavalcanti
Morgado, Mariza Gonçalves
dc.subject.other.pt_BR.fl_str_mv Tuberculose
AIDS
Resposta imune
EnsaIo de Immunospot Ligado a Enzimas
topic Tuberculose
AIDS
Resposta imune
EnsaIo de Immunospot Ligado a Enzimas
Tuberculosis
AIDS
Immune response
ELISpot
IRIS
dc.subject.en.pt_BR.fl_str_mv Tuberculosis
AIDS
Immune response
ELISpot
IRIS
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-02-27T16:42:30Z
dc.date.available.fl_str_mv 2018-02-27T16:42:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Tatiana Pereira da et al. Risk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIVinfected, antiretroviral-naïve patients. BMC Infectious Diseases, v. 17, p. 1-10, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/24981
dc.identifier.issn.pt_BR.fl_str_mv 1471-2334
dc.identifier.doi.none.fl_str_mv 10.1186/s12879-017-2700-6
identifier_str_mv SILVA, Tatiana Pereira da et al. Risk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIVinfected, antiretroviral-naïve patients. BMC Infectious Diseases, v. 17, p. 1-10, 2017.
1471-2334
10.1186/s12879-017-2700-6
url https://www.arca.fiocruz.br/handle/icict/24981
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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