Intralesional meglumine antimoniate for the treatment of localised cutaneous leishmaniasis: a retrospective review of a Brazilian referral centre

Detalhes bibliográficos
Autor(a) principal: Silva, Rosiana Estéfane da
Data de Publicação: 2016
Outros Autores: Toledo Junior, Antonio Carlos de Castro, Senna, Maria Camilo, Rabello, Ana Lucia Teles, Cota, Gláucia Fernandes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/19936
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Referência em Leishmanioses. Pesquisas Clínicas e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brasil.
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spelling Silva, Rosiana Estéfane daToledo Junior, Antonio Carlos de CastroSenna, Maria CamiloRabello, Ana Lucia TelesCota, Gláucia Fernandes2017-07-10T17:42:17Z2017-07-10T17:42:17Z2016SILVA, Rosiana Estéfane da et al. Intralesional meglumine antimoniate for the treatment of localised cutaneous leishmaniasis: a retrospective review of a Brazilian referral centre. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 111, n. 8, p. 512-516, 2016.0074-0276https://www.arca.fiocruz.br/handle/icict/1993610.1590/0074-02760160183engInstituto Oswaldo CruzLeishmaniose cutaneaTerapiaCutaneous leishmaniasisTherapyIntralesional infiltrationAntimoniate meglumineIntralesional meglumine antimoniate for the treatment of localised cutaneous leishmaniasis: a retrospective review of a Brazilian referral centreinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Referência em Leishmanioses. Pesquisas Clínicas e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brasil.Universidade José do Rosário Vellano. Faculdade de Medicina. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Referência em Leishmanioses. Pesquisas Clínicas e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Referência em Leishmanioses. Pesquisas Clínicas e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Referência em Leishmanioses. Pesquisas Clínicas e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brasil.Although intralesional meglumine antimoniate (MA) infiltration is considered an option for cutaneous leishmaniasis (CL) therapy and is widely used in the Old World, there have been few studies supporting this therapeutic approach in the Americas. This study aims to describe outcomes and adverse events associated with intralesional therapy for CL. This retrospective study reviewed the experience of a Brazilian leishmaniasis reference centre using intralesional MA to treat 31 patients over five years (2008 and 2013). The median age was 63 years (22-86) and the median duration time of the lesions up to treatment was 16 weeks. In 22 patients (71%), intralesional therapy was indicated due to the presence of contraindications or previous serious adverse events with systemic MA. Other indications were failure of systemic therapy or ease of administration. Intralesional treatment consisted of one-six infiltrations (median three) for a period of up to 12 weeks. The initial (three months) and definitive (six months) cure rates were 70.9% and 67.7%, respectively. Most patients reported mild discomfort during infiltration and no serious adverse events were observed. In conclusion, these results show that the intralesional MA efficacy rate was very similar to that of systemic MA treatment, and reinforce the need for further studies with adequate design to establish the efficacy and safety of this therapeutic approach.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/19936/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALIntralesional meglumine antimoniate for the treatment of localised cutaneous leishmaniasis.pdfIntralesional meglumine antimoniate for the treatment of localised cutaneous leishmaniasis.pdfapplication/pdf4166264https://www.arca.fiocruz.br/bitstream/icict/19936/2/Intralesional%20meglumine%20antimoniate%20for%20the%20treatment%20of%20localised%20cutaneous%20leishmaniasis.pdf52790bbad09ef518d09eac5e6652be14MD52TEXTIntralesional meglumine 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dc.title.pt_BR.fl_str_mv Intralesional meglumine antimoniate for the treatment of localised cutaneous leishmaniasis: a retrospective review of a Brazilian referral centre
title Intralesional meglumine antimoniate for the treatment of localised cutaneous leishmaniasis: a retrospective review of a Brazilian referral centre
spellingShingle Intralesional meglumine antimoniate for the treatment of localised cutaneous leishmaniasis: a retrospective review of a Brazilian referral centre
Silva, Rosiana Estéfane da
Leishmaniose cutanea
Terapia
Cutaneous leishmaniasis
Therapy
Intralesional infiltration
Antimoniate meglumine
title_short Intralesional meglumine antimoniate for the treatment of localised cutaneous leishmaniasis: a retrospective review of a Brazilian referral centre
title_full Intralesional meglumine antimoniate for the treatment of localised cutaneous leishmaniasis: a retrospective review of a Brazilian referral centre
title_fullStr Intralesional meglumine antimoniate for the treatment of localised cutaneous leishmaniasis: a retrospective review of a Brazilian referral centre
title_full_unstemmed Intralesional meglumine antimoniate for the treatment of localised cutaneous leishmaniasis: a retrospective review of a Brazilian referral centre
title_sort Intralesional meglumine antimoniate for the treatment of localised cutaneous leishmaniasis: a retrospective review of a Brazilian referral centre
author Silva, Rosiana Estéfane da
author_facet Silva, Rosiana Estéfane da
Toledo Junior, Antonio Carlos de Castro
Senna, Maria Camilo
Rabello, Ana Lucia Teles
Cota, Gláucia Fernandes
author_role author
author2 Toledo Junior, Antonio Carlos de Castro
Senna, Maria Camilo
Rabello, Ana Lucia Teles
Cota, Gláucia Fernandes
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva, Rosiana Estéfane da
Toledo Junior, Antonio Carlos de Castro
Senna, Maria Camilo
Rabello, Ana Lucia Teles
Cota, Gláucia Fernandes
dc.subject.other.pt_BR.fl_str_mv Leishmaniose cutanea
Terapia
topic Leishmaniose cutanea
Terapia
Cutaneous leishmaniasis
Therapy
Intralesional infiltration
Antimoniate meglumine
dc.subject.en.pt_BR.fl_str_mv Cutaneous leishmaniasis
Therapy
Intralesional infiltration
Antimoniate meglumine
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Referência em Leishmanioses. Pesquisas Clínicas e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brasil.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-07-10T17:42:17Z
dc.date.available.fl_str_mv 2017-07-10T17:42:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Rosiana Estéfane da et al. Intralesional meglumine antimoniate for the treatment of localised cutaneous leishmaniasis: a retrospective review of a Brazilian referral centre. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 111, n. 8, p. 512-516, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/19936
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760160183
identifier_str_mv SILVA, Rosiana Estéfane da et al. Intralesional meglumine antimoniate for the treatment of localised cutaneous leishmaniasis: a retrospective review of a Brazilian referral centre. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 111, n. 8, p. 512-516, 2016.
0074-0276
10.1590/0074-02760160183
url https://www.arca.fiocruz.br/handle/icict/19936
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz
publisher.none.fl_str_mv Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/19936/1/license.txt
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