Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole

Detalhes bibliográficos
Autor(a) principal: Andrade, Sonia Gumes
Data de Publicação: 1989
Outros Autores: Silva, R.C, Santiago, Christiane M.G
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14627
Resumo: Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Andrade, Sonia GumesSilva, R.CSantiago, Christiane M.G2016-06-27T18:04:12Z2016-07-07T11:39:44Z2016-06-27T18:04:12Z2016-07-07T11:39:44Z1989ANDRADE, S. G.; SILVA, R. C.; SANTIAGO, C. M. G. Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole. Bulletin of the World Health Organization, v. 67, n. 5, p. 509-514, 1989.0042-9686https://www.arca.fiocruz.br/handle/icict/14627porWorld Health OrganizationTreatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazoleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilThe antiprotozoal drug 3-(1-methyl-5-nitroimidazol-2-yl)-3a, 4,5,6,7,7a-hexahydro-1,2-benzisoxazole (MK-436) is highly efficacious for treating mice chronically infected with different strains of Trypanosoma cruzi. The compound was administered by gavage in two daily doses of250mg per kg body weight to 130 mice that had been infected for 90 to 400 days with either type II or Ill strains of T. cruzi. The following parasitological cure tests were carried out: xenodiagnosis, haemoculture, and inoculation of blood into newborn mice. Indirect immunofluorescence tests and histopathological studies were also performed. The results indicate that the drug is highly efficacious against chronic infection caused by both type II (cure rate, 90%) and type Ill strains (cure rate, 95.7%). Histopathological examinations showed complete clearance of the cardiac and muscular lesions in 36% of the mice infected with type II strains and a decrease in the intensity and extension of the lesions in mice infected with type Ill strains. Indirect immunofluorescence tests were persistently positive for all the mice 3-6 months after the treatment.Chagas diseaseXenodiagnosisMK-436Trypanosoma cruziAnimalsNitroimidazoleAntiprotozoal agentsTherapyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTAndrade SG Treatment of chronic....pdf.txtAndrade SG Treatment of chronic....pdf.txtExtracted texttext/plain21505https://www.arca.fiocruz.br/bitstream/icict/14627/4/Andrade%20SG%20Treatment%20of%20chronic....pdf.txt0fc5229d092f56dbcc85be35a4159fa0MD54ORIGINALAndrade SG Treatment of chronic....pdfapplication/pdf1732935https://www.arca.fiocruz.br/bitstream/icict/14627/2/Andrade%20SG%20Treatment%20of%20chronic....pdf0875391791aa53463594be39db93e8a9MD52LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/14627/3/license.txt5a560609d32a3863062d77ff32785d58MD53icict/146272023-03-15 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dc.title.pt_BR.fl_str_mv Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole
title Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole
spellingShingle Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole
Andrade, Sonia Gumes
Chagas disease
Xenodiagnosis
MK-436
Trypanosoma cruzi
Animals
Nitroimidazole
Antiprotozoal agents
Therapy
title_short Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole
title_full Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole
title_fullStr Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole
title_full_unstemmed Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole
title_sort Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole
author Andrade, Sonia Gumes
author_facet Andrade, Sonia Gumes
Silva, R.C
Santiago, Christiane M.G
author_role author
author2 Silva, R.C
Santiago, Christiane M.G
author2_role author
author
dc.contributor.author.fl_str_mv Andrade, Sonia Gumes
Silva, R.C
Santiago, Christiane M.G
dc.subject.en.pt_BR.fl_str_mv Chagas disease
Xenodiagnosis
MK-436
Trypanosoma cruzi
Animals
Nitroimidazole
Antiprotozoal agents
Therapy
topic Chagas disease
Xenodiagnosis
MK-436
Trypanosoma cruzi
Animals
Nitroimidazole
Antiprotozoal agents
Therapy
description Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1989
dc.date.issued.fl_str_mv 1989
dc.date.accessioned.fl_str_mv 2016-06-27T18:04:12Z
2016-07-07T11:39:44Z
dc.date.available.fl_str_mv 2016-06-27T18:04:12Z
2016-07-07T11:39:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, S. G.; SILVA, R. C.; SANTIAGO, C. M. G. Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole. Bulletin of the World Health Organization, v. 67, n. 5, p. 509-514, 1989.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14627
dc.identifier.issn.pt_BR.fl_str_mv 0042-9686
identifier_str_mv ANDRADE, S. G.; SILVA, R. C.; SANTIAGO, C. M. G. Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole. Bulletin of the World Health Organization, v. 67, n. 5, p. 509-514, 1989.
0042-9686
url https://www.arca.fiocruz.br/handle/icict/14627
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv World Health Organization
publisher.none.fl_str_mv World Health Organization
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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