Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole
Autor(a) principal: | |
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Data de Publicação: | 1989 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14627 |
Resumo: | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Andrade, Sonia GumesSilva, R.CSantiago, Christiane M.G2016-06-27T18:04:12Z2016-07-07T11:39:44Z2016-06-27T18:04:12Z2016-07-07T11:39:44Z1989ANDRADE, S. G.; SILVA, R. C.; SANTIAGO, C. M. G. Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole. Bulletin of the World Health Organization, v. 67, n. 5, p. 509-514, 1989.0042-9686https://www.arca.fiocruz.br/handle/icict/14627porWorld Health OrganizationTreatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazoleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilThe antiprotozoal drug 3-(1-methyl-5-nitroimidazol-2-yl)-3a, 4,5,6,7,7a-hexahydro-1,2-benzisoxazole (MK-436) is highly efficacious for treating mice chronically infected with different strains of Trypanosoma cruzi. The compound was administered by gavage in two daily doses of250mg per kg body weight to 130 mice that had been infected for 90 to 400 days with either type II or Ill strains of T. cruzi. The following parasitological cure tests were carried out: xenodiagnosis, haemoculture, and inoculation of blood into newborn mice. Indirect immunofluorescence tests and histopathological studies were also performed. The results indicate that the drug is highly efficacious against chronic infection caused by both type II (cure rate, 90%) and type Ill strains (cure rate, 95.7%). Histopathological examinations showed complete clearance of the cardiac and muscular lesions in 36% of the mice infected with type II strains and a decrease in the intensity and extension of the lesions in mice infected with type Ill strains. Indirect immunofluorescence tests were persistently positive for all the mice 3-6 months after the treatment.Chagas diseaseXenodiagnosisMK-436Trypanosoma cruziAnimalsNitroimidazoleAntiprotozoal agentsTherapyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTAndrade SG Treatment of chronic....pdf.txtAndrade SG Treatment of chronic....pdf.txtExtracted texttext/plain21505https://www.arca.fiocruz.br/bitstream/icict/14627/4/Andrade%20SG%20Treatment%20of%20chronic....pdf.txt0fc5229d092f56dbcc85be35a4159fa0MD54ORIGINALAndrade SG Treatment of chronic....pdfapplication/pdf1732935https://www.arca.fiocruz.br/bitstream/icict/14627/2/Andrade%20SG%20Treatment%20of%20chronic....pdf0875391791aa53463594be39db93e8a9MD52LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/14627/3/license.txt5a560609d32a3863062d77ff32785d58MD53icict/146272023-03-15 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dc.title.pt_BR.fl_str_mv |
Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole |
title |
Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole |
spellingShingle |
Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole Andrade, Sonia Gumes Chagas disease Xenodiagnosis MK-436 Trypanosoma cruzi Animals Nitroimidazole Antiprotozoal agents Therapy |
title_short |
Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole |
title_full |
Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole |
title_fullStr |
Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole |
title_full_unstemmed |
Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole |
title_sort |
Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole |
author |
Andrade, Sonia Gumes |
author_facet |
Andrade, Sonia Gumes Silva, R.C Santiago, Christiane M.G |
author_role |
author |
author2 |
Silva, R.C Santiago, Christiane M.G |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Andrade, Sonia Gumes Silva, R.C Santiago, Christiane M.G |
dc.subject.en.pt_BR.fl_str_mv |
Chagas disease Xenodiagnosis MK-436 Trypanosoma cruzi Animals Nitroimidazole Antiprotozoal agents Therapy |
topic |
Chagas disease Xenodiagnosis MK-436 Trypanosoma cruzi Animals Nitroimidazole Antiprotozoal agents Therapy |
description |
Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
publishDate |
1989 |
dc.date.issued.fl_str_mv |
1989 |
dc.date.accessioned.fl_str_mv |
2016-06-27T18:04:12Z 2016-07-07T11:39:44Z |
dc.date.available.fl_str_mv |
2016-06-27T18:04:12Z 2016-07-07T11:39:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ANDRADE, S. G.; SILVA, R. C.; SANTIAGO, C. M. G. Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole. Bulletin of the World Health Organization, v. 67, n. 5, p. 509-514, 1989. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/14627 |
dc.identifier.issn.pt_BR.fl_str_mv |
0042-9686 |
identifier_str_mv |
ANDRADE, S. G.; SILVA, R. C.; SANTIAGO, C. M. G. Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole. Bulletin of the World Health Organization, v. 67, n. 5, p. 509-514, 1989. 0042-9686 |
url |
https://www.arca.fiocruz.br/handle/icict/14627 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
World Health Organization |
publisher.none.fl_str_mv |
World Health Organization |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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