Anti-neutrophil cytoplasmic antibodies in leprosy.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2007 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7547 |
Resumo: | Universidade Federal da Bahia. Salvador, BA, Brasil / |
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Edington, Fernando Luiz BarrosBacellar, Maria Olívia Amado RamosMachado, Paulo RobertoBarbosa, Lúcio MacedoReis, Eliana Almeida GomesReis, Mitermayer Galvão dosSantiago, Mittermayer Barreto2014-04-28T13:00:13Z2014-04-28T13:00:13Z2007EDINGTON, F. L. B. et al. Anti-neutrophil cytoplasmic antibodies in leprosy. Clinical Rheumatology, v. 26, n. 2, p. 208-210, 2007.0770-3198https://www.arca.fiocruz.br/handle/icict/754710.1007/s10067-006-0281-7engSpringer VerlagAnti-neutrophil cytoplasmic antibodies in leprosy.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Salvador, BA, Brasil /Universidade Federal da Bahia. Laboratório de Imunologia do Hospital Universitário Professor Edgard Santos. Salvador, BA, BrasilEscola Baiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Federal da Bahia, Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilEscola Baiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Santa Izabel. Serviço de Reumatologia. Salvador, BA, BrasilIntroduction: Anti-Neutrophil Cytoplasmic Antibodies (ANCA) are auto-antibodies directed to intracellular components of neutrophils and used to be considered as present almost exclusively in granulomatous vasculitis. Recently, these auto-antibodies have been found in other autoimmune disorders as well as infectious diseases. Materials and methods: We studied patients with leprosy confirmed by bacilloscopy and/or skin biopsy, in reaction phase from the Ambulatório de Hanseníase do Hospital Universitário Professor Edgar Santos. ANCA and Antinuclear antibodies (ANA) were determined by indirect immunofluorescence using commercially available kits. Results: Twenty patients were enrolled in our study, nine males and 11 females. The mean age was 36.9± 18.2 years. ANCA were present only in one patient, with a perinuclear staining pattern (p-ANCA), and no patient tested positive for ANA. Discussion: Although other studies have shown the presence of ANCA in leprosy, the low frequency of these antibodies in leprosy sera demonstrated in the present study illustrates the high specificity of ANCA for the diagnosis of Wegener granulomatosis.Auto-antibodiesHansen diseaseLeprosyVasculitisAnticorpos Anticitoplasma de Neutrófilos/sangueHanseníase/imunologiaAdolescenteAdultoIdosoBiópsiaCriançaFemininoTécnica Indireta de Fluorescência para AnticorpoHumanosHanseníase/patologiaMasculinoMeia-IdadeMycobacterium leprae/citologiaMycobacterium leprae/isolamento & purificaçãoKit de Reagentes para DiagnósticoPele/microbiologiaPele/patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALEdington FLB Anti-neutrophil....pdfEdington FLB Anti-neutrophil....pdfapplication/pdf69362https://www.arca.fiocruz.br/bitstream/icict/7547/1/Edington%20FLB%20Anti-neutrophil....pdf4a4ac3016be606f1034e4f446beef14bMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7547/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTEdington FLB Anti-neutrophil....pdf.txtEdington FLB Anti-neutrophil....pdf.txtExtracted texttext/plain11098https://www.arca.fiocruz.br/bitstream/icict/7547/5/Edington%20FLB%20Anti-neutrophil....pdf.txtdf6b3b4dd664dcfd9a7863ea7299d1b8MD55THUMBNAILEdington FLB Anti-neutrophil....pdf.jpgEdington FLB Anti-neutrophil....pdf.jpgGenerated Thumbnailimage/jpeg2274https://www.arca.fiocruz.br/bitstream/icict/7547/4/Edington%20FLB%20Anti-neutrophil....pdf.jpg7c9ba4f1df563d610c40d6b4f2fc003fMD54icict/75472023-03-15 14:33:17.76oai:www.arca.fiocruz.br:icict/7547TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Anti-neutrophil cytoplasmic antibodies in leprosy. |
| title |
Anti-neutrophil cytoplasmic antibodies in leprosy. |
| spellingShingle |
Anti-neutrophil cytoplasmic antibodies in leprosy. Edington, Fernando Luiz Barros Auto-antibodies Hansen disease Leprosy Vasculitis Anticorpos Anticitoplasma de Neutrófilos/sangue Hanseníase/imunologia Adolescente Adulto Idoso Biópsia Criança Feminino Técnica Indireta de Fluorescência para Anticorpo Humanos Hanseníase/patologia Masculino Meia-Idade Mycobacterium leprae/citologia Mycobacterium leprae/isolamento & purificação Kit de Reagentes para Diagnóstico Pele/microbiologia Pele/patologia |
| title_short |
Anti-neutrophil cytoplasmic antibodies in leprosy. |
| title_full |
Anti-neutrophil cytoplasmic antibodies in leprosy. |
| title_fullStr |
Anti-neutrophil cytoplasmic antibodies in leprosy. |
| title_full_unstemmed |
Anti-neutrophil cytoplasmic antibodies in leprosy. |
| title_sort |
Anti-neutrophil cytoplasmic antibodies in leprosy. |
| author |
Edington, Fernando Luiz Barros |
| author_facet |
Edington, Fernando Luiz Barros Bacellar, Maria Olívia Amado Ramos Machado, Paulo Roberto Barbosa, Lúcio Macedo Reis, Eliana Almeida Gomes Reis, Mitermayer Galvão dos Santiago, Mittermayer Barreto |
| author_role |
author |
| author2 |
Bacellar, Maria Olívia Amado Ramos Machado, Paulo Roberto Barbosa, Lúcio Macedo Reis, Eliana Almeida Gomes Reis, Mitermayer Galvão dos Santiago, Mittermayer Barreto |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Edington, Fernando Luiz Barros Bacellar, Maria Olívia Amado Ramos Machado, Paulo Roberto Barbosa, Lúcio Macedo Reis, Eliana Almeida Gomes Reis, Mitermayer Galvão dos Santiago, Mittermayer Barreto |
| dc.subject.en.pt_BR.fl_str_mv |
Auto-antibodies Hansen disease Leprosy Vasculitis |
| topic |
Auto-antibodies Hansen disease Leprosy Vasculitis Anticorpos Anticitoplasma de Neutrófilos/sangue Hanseníase/imunologia Adolescente Adulto Idoso Biópsia Criança Feminino Técnica Indireta de Fluorescência para Anticorpo Humanos Hanseníase/patologia Masculino Meia-Idade Mycobacterium leprae/citologia Mycobacterium leprae/isolamento & purificação Kit de Reagentes para Diagnóstico Pele/microbiologia Pele/patologia |
| dc.subject.decs.pt_BR.fl_str_mv |
Anticorpos Anticitoplasma de Neutrófilos/sangue Hanseníase/imunologia Adolescente Adulto Idoso Biópsia Criança Feminino Técnica Indireta de Fluorescência para Anticorpo Humanos Hanseníase/patologia Masculino Meia-Idade Mycobacterium leprae/citologia Mycobacterium leprae/isolamento & purificação Kit de Reagentes para Diagnóstico Pele/microbiologia Pele/patologia |
| description |
Universidade Federal da Bahia. Salvador, BA, Brasil / |
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2007 |
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2007 |
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2014-04-28T13:00:13Z |
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2014-04-28T13:00:13Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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EDINGTON, F. L. B. et al. Anti-neutrophil cytoplasmic antibodies in leprosy. Clinical Rheumatology, v. 26, n. 2, p. 208-210, 2007. |
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https://www.arca.fiocruz.br/handle/icict/7547 |
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0770-3198 |
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10.1007/s10067-006-0281-7 |
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EDINGTON, F. L. B. et al. Anti-neutrophil cytoplasmic antibodies in leprosy. Clinical Rheumatology, v. 26, n. 2, p. 208-210, 2007. 0770-3198 10.1007/s10067-006-0281-7 |
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Springer Verlag |
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Springer Verlag |
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