Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/17861 |
Resumo: | David Geffen School of Medicine at UCLA. Department of Molecular. Cell, and Developmental Biology. California, USA. |
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Inkeles, Megan S.Teles, Rosane M. B.Pouldar, DelilaAndrade, Priscila R.Madigan, Cressida A.Lopez, DavidAmbrose, MikeNoursadeghi, MahdadSarno, Euzenir N.Rea, Thomas H.Ochoa, Maria T.Iruela-Arispe, M LuisaSwindell, William R.Ottenhoff, Tom H. M.Geluk, AnnemiekeBloom, Barry R.Pellegrini, MatteoModlin, Robert L.2017-02-21T11:30:39Z2017-02-21T11:30:39Z2016INKELES, Megan S. et al. Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy. JCI Insight, v.1, n.15, e88843, 16p, sept. 2016.2379-3708https://www.arca.fiocruz.br/handle/icict/1786110.1172/jci.insight.88843engAmerican Society for Clinical InvestigationHanseníaseDeconvolução de tipo celularVias imunológicasRedes genéticasDefesas do hospedeiroLeprosyimmune pathwaysCell-type deconvolutionhost defenseimmune pathwaysgene networksCell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDavid Geffen School of Medicine at UCLA. Department of Molecular. Cell, and Developmental Biology. California, USA.David Geffen School of Medicine at UCLA. Division of Dermatology. California, USA.David Geffen School of Medicine at UCLA. Division of Dermatology. California, USA.David Geffen School of Medicine at UCLA. Division of Dermatology. California, USA.David Geffen School of Medicine at UCLA. Division of Dermatology. California, USA.David Geffen School of Medicine at UCLA. Department of Molecular. Cell, and Developmental Biology. California, USA.David Geffen School of Medicine at UCLA. Department of Molecular. Cell, and Developmental Biology. California, USA.University College London. Division of Infection and Immunity. London, United Kingdom.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.University of Southern California School of Medicine. Department of Dermatology. Los Angeles, CA, USA.University of Southern California School of Medicine. Department of Dermatology. Los Angeles, CA, USA.David Geffen School of Medicine at UCLA. Department of Molecular. Cell, and Developmental Biology. California, USA.University of Michigan School of Medicine. Department of Dermatology. Ann Arbor, Michigan, USA.Leiden University Medical Center. Department of Infectious Diseases. Leiden, Netherlands.Leiden University Medical Center. Department of Infectious Diseases. Leiden, Netherlands.Harvard School of Public Health. Boston, Massachusetts, USA.David Geffen School of Medicine at UCLA. Department of Molecular. Cell, and Developmental Biology. California, USA.David Geffen School of Medicine at UCLA. Division of Dermatology. California, USA / UCLA. Department of Microbiology, Immunology and Molecular Genetics. Los Angeles, California, USATranscriptome profiles derived from the site of human disease have led to the identification of genes that contribute to pathogenesis, yet the complex mixture of cell types in these lesions has been an obstacle for defining specific mechanisms. Leprosy provides an outstanding model to study host defense and pathogenesis in a human infectious disease, given its clinical spectrum, which interrelates with the host immunologic and pathologic responses. Here, we investigated gene expression profiles derived from skin lesions for each clinical subtype of leprosy, analyzing gene coexpression modules by cell-type deconvolution. In lesions from tuberculoid leprosy patients, those with the self-limited form of the disease, dendritic cells were linked with MMP12 as part of a tissue remodeling network that contributes to granuloma formation. In lesions from lepromatous leprosy patients, those with disseminated disease, macrophages were linked with a gene network that programs phagocytosis. In erythema nodosum leprosum, neutrophil and endothelial cell gene networks were identified as part of the vasculitis that results in tissue injury. The present integrated computational approach provides a systems approach toward identifying cell-defined functional networks that contribute to host defense and immunopathology at the site of human infectious disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17861/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALeuzenir_sarno_etal_IOC_2016.pdfeuzenir_sarno_etal_IOC_2016.pdfapplication/pdf1438335https://www.arca.fiocruz.br/bitstream/icict/17861/2/euzenir_sarno_etal_IOC_2016.pdfaa97b092804532f27f2c242364567135MD52TEXTeuzenir_sarno_etal_IOC_2016.pdf.txteuzenir_sarno_etal_IOC_2016.pdf.txtExtracted texttext/plain63229https://www.arca.fiocruz.br/bitstream/icict/17861/3/euzenir_sarno_etal_IOC_2016.pdf.txt1e5c8709e012023619600505f3f94906MD53icict/178612018-08-15 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| dc.title.pt_BR.fl_str_mv |
Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy |
| title |
Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy |
| spellingShingle |
Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy Inkeles, Megan S. Hanseníase Deconvolução de tipo celular Vias imunológicas Redes genéticas Defesas do hospedeiro Leprosy immune pathways Cell-type deconvolution host defense immune pathways gene networks |
| title_short |
Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy |
| title_full |
Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy |
| title_fullStr |
Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy |
| title_full_unstemmed |
Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy |
| title_sort |
Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy |
| author |
Inkeles, Megan S. |
| author_facet |
Inkeles, Megan S. Teles, Rosane M. B. Pouldar, Delila Andrade, Priscila R. Madigan, Cressida A. Lopez, David Ambrose, Mike Noursadeghi, Mahdad Sarno, Euzenir N. Rea, Thomas H. Ochoa, Maria T. Iruela-Arispe, M Luisa Swindell, William R. Ottenhoff, Tom H. M. Geluk, Annemieke Bloom, Barry R. Pellegrini, Matteo Modlin, Robert L. |
| author_role |
author |
| author2 |
Teles, Rosane M. B. Pouldar, Delila Andrade, Priscila R. Madigan, Cressida A. Lopez, David Ambrose, Mike Noursadeghi, Mahdad Sarno, Euzenir N. Rea, Thomas H. Ochoa, Maria T. Iruela-Arispe, M Luisa Swindell, William R. Ottenhoff, Tom H. M. Geluk, Annemieke Bloom, Barry R. Pellegrini, Matteo Modlin, Robert L. |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Inkeles, Megan S. Teles, Rosane M. B. Pouldar, Delila Andrade, Priscila R. Madigan, Cressida A. Lopez, David Ambrose, Mike Noursadeghi, Mahdad Sarno, Euzenir N. Rea, Thomas H. Ochoa, Maria T. Iruela-Arispe, M Luisa Swindell, William R. Ottenhoff, Tom H. M. Geluk, Annemieke Bloom, Barry R. Pellegrini, Matteo Modlin, Robert L. |
| dc.subject.other.pt_BR.fl_str_mv |
Hanseníase Deconvolução de tipo celular Vias imunológicas Redes genéticas Defesas do hospedeiro |
| topic |
Hanseníase Deconvolução de tipo celular Vias imunológicas Redes genéticas Defesas do hospedeiro Leprosy immune pathways Cell-type deconvolution host defense immune pathways gene networks |
| dc.subject.en.pt_BR.fl_str_mv |
Leprosy immune pathways Cell-type deconvolution host defense immune pathways gene networks |
| description |
David Geffen School of Medicine at UCLA. Department of Molecular. Cell, and Developmental Biology. California, USA. |
| publishDate |
2016 |
| dc.date.issued.fl_str_mv |
2016 |
| dc.date.accessioned.fl_str_mv |
2017-02-21T11:30:39Z |
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2017-02-21T11:30:39Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
INKELES, Megan S. et al. Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy. JCI Insight, v.1, n.15, e88843, 16p, sept. 2016. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/17861 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2379-3708 |
| dc.identifier.doi.none.fl_str_mv |
10.1172/jci.insight.88843 |
| identifier_str_mv |
INKELES, Megan S. et al. Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy. JCI Insight, v.1, n.15, e88843, 16p, sept. 2016. 2379-3708 10.1172/jci.insight.88843 |
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American Society for Clinical Investigation |
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American Society for Clinical Investigation |
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