Antitrypanosomal activity of Brazilian Propolis from apis mellifera
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2004 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/41321 |
Resumo: | Universidade São Francisco. Faculdade de Ciências Farmacêuticas. Bragança Paulista, SP, Brasil. |
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Cunha, Ildenize Barbosa da SilvaSalomão, KellyShimizu, MarioBankova, Vassya S.Custódio, Angela RamalhoCastro, Solange Lisboa deMarcucci, Maria Cristina2020-05-20T14:45:58Z2020-05-20T14:45:58Z2004CUNHA, Ildenize Barbosa da Silva et al. Antitrypanosomal activity of Brazilian Propolis from Apis Mellifera. Chem. Pharm. Bull., v. 52, n. 5, p. 602-604, 2004.0009-2363https://www.arca.fiocruz.br/handle/icict/4132110.1248/cpb.52.6021347-5223engPharmaceutical Society of JapanPrópolis brasileiroComposição químicaHPLCTrypanosoma cruziProcedimento de extraçãoBrazilian propolisExtraction procedureChemical compositionHPLCTrypanosoma cruziAntitrypanosomal activity of Brazilian Propolis from apis melliferainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade São Francisco. Faculdade de Ciências Farmacêuticas. Bragança Paulista, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-Estrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.Universidade São Francisco. Faculdade de Ciências Farmacêuticas. Bragança Paulista, SP, Brasil.Bulgarian Academy of Scienses. Institute of Organic Chemistry with Centre for Phytochemisty. Sofia, Bulgaria.Natural Labor, Análises e Pesquisas. Campinas, SP, Brasil.Universidade Bandeirante de São Paulo. Núcleo de Pós-Graduação, Pesquisa e Extensão. São Paulo, SP, Brasil. .Extracts from different samples of Brazilian propolis were obtained by Soxhlet extraction or maceration at room temperature using ethanol, water, and accombination of both solvents. Analysis of their composition using HPLC revealed that no major differences were seen when a propolis sample was subject to different extraction methods. The activity of the 15 extracts was assayed against bloodstream trypomastigotes of Trypanosoma cruzi, the etiologic agent of Chagas’ disease. Multivariate analysis was applied to evaluate the efficiency of the different extracts and the trypanocidal activity. The extracts could be divided into two groups. In the first, in which, extracts were obtained by reflux in Soxhlet using 100% ethanol, there was a lower content of bioactive compounds and consequently lower trypanocidal activity. Extract 136-Et100 stands out in this group, since it had the highest levels of bioactive compounds together with highest activity against the parasite when compared with all other extracts. The second group comprises extracts with intermediate levels of bioactive compounds and higher activity against T. cruzi.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/41321/1/license.txt5a560609d32a3863062d77ff32785d58MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/41321/2/license.txt5a560609d32a3863062d77ff32785d58MD52ORIGINALSloangeLCsatro_KellySalomao_etal_IOC_2004.pdfSloangeLCsatro_KellySalomao_etal_IOC_2004.pdfapplication/pdf64137https://www.arca.fiocruz.br/bitstream/icict/41321/3/SloangeLCsatro_KellySalomao_etal_IOC_2004.pdfc9b47ab891e6f466eeb7791ef0ec0281MD53icict/413212020-05-20 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| dc.title.pt_BR.fl_str_mv |
Antitrypanosomal activity of Brazilian Propolis from apis mellifera |
| title |
Antitrypanosomal activity of Brazilian Propolis from apis mellifera |
| spellingShingle |
Antitrypanosomal activity of Brazilian Propolis from apis mellifera Cunha, Ildenize Barbosa da Silva Própolis brasileiro Composição química HPLC Trypanosoma cruzi Procedimento de extração Brazilian propolis Extraction procedure Chemical composition HPLC Trypanosoma cruzi |
| title_short |
Antitrypanosomal activity of Brazilian Propolis from apis mellifera |
| title_full |
Antitrypanosomal activity of Brazilian Propolis from apis mellifera |
| title_fullStr |
Antitrypanosomal activity of Brazilian Propolis from apis mellifera |
| title_full_unstemmed |
Antitrypanosomal activity of Brazilian Propolis from apis mellifera |
| title_sort |
Antitrypanosomal activity of Brazilian Propolis from apis mellifera |
| author |
Cunha, Ildenize Barbosa da Silva |
| author_facet |
Cunha, Ildenize Barbosa da Silva Salomão, Kelly Shimizu, Mario Bankova, Vassya S. Custódio, Angela Ramalho Castro, Solange Lisboa de Marcucci, Maria Cristina |
| author_role |
author |
| author2 |
Salomão, Kelly Shimizu, Mario Bankova, Vassya S. Custódio, Angela Ramalho Castro, Solange Lisboa de Marcucci, Maria Cristina |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Cunha, Ildenize Barbosa da Silva Salomão, Kelly Shimizu, Mario Bankova, Vassya S. Custódio, Angela Ramalho Castro, Solange Lisboa de Marcucci, Maria Cristina |
| dc.subject.other.pt_BR.fl_str_mv |
Própolis brasileiro Composição química HPLC Trypanosoma cruzi Procedimento de extração |
| topic |
Própolis brasileiro Composição química HPLC Trypanosoma cruzi Procedimento de extração Brazilian propolis Extraction procedure Chemical composition HPLC Trypanosoma cruzi |
| dc.subject.en.pt_BR.fl_str_mv |
Brazilian propolis Extraction procedure Chemical composition HPLC Trypanosoma cruzi |
| description |
Universidade São Francisco. Faculdade de Ciências Farmacêuticas. Bragança Paulista, SP, Brasil. |
| publishDate |
2004 |
| dc.date.issued.fl_str_mv |
2004 |
| dc.date.accessioned.fl_str_mv |
2020-05-20T14:45:58Z |
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2020-05-20T14:45:58Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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CUNHA, Ildenize Barbosa da Silva et al. Antitrypanosomal activity of Brazilian Propolis from Apis Mellifera. Chem. Pharm. Bull., v. 52, n. 5, p. 602-604, 2004. |
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https://www.arca.fiocruz.br/handle/icict/41321 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0009-2363 |
| dc.identifier.doi.none.fl_str_mv |
10.1248/cpb.52.602 |
| dc.identifier.eissn.none.fl_str_mv |
1347-5223 |
| identifier_str_mv |
CUNHA, Ildenize Barbosa da Silva et al. Antitrypanosomal activity of Brazilian Propolis from Apis Mellifera. Chem. Pharm. Bull., v. 52, n. 5, p. 602-604, 2004. 0009-2363 10.1248/cpb.52.602 1347-5223 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Pharmaceutical Society of Japan |
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Pharmaceutical Society of Japan |
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