Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study

Detalhes bibliográficos
Autor(a) principal: Andrade, Luciana O.
Data de Publicação: 2010
Outros Autores: Galvão, Lúcia M. C., Meirelles, Maria de Nazareth S. L., Chiari, Egler, Pena, Sergio D. J., Macedo, Andrea M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28005
Resumo: Universidade Federal de Minas Gerais. Departamento de Morfologia. Belo Horizonte, MG, Brasil.
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spelling Andrade, Luciana O.Galvão, Lúcia M. C.Meirelles, Maria de Nazareth S. L.Chiari, EglerPena, Sergio D. J.Macedo, Andrea M.2018-08-08T13:39:04Z2018-08-08T13:39:04Z2010ANDRADE, Luciana O. et al. Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study. Mem Inst Oswaldo Cruz,v.105, n.6, p.834-837, Sept. 20100074-0276https://www.arca.fiocruz.br/handle/icict/280051678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzTrypanosoma CruziDoença de Chagastropismo tecidualcardiomiócitosTrypanosoma CruziChagas Diseasetissue tropismcardiomyocytesDifferential tissue tropism of Trypanosoma cruzi strains: an in vitro studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Departamento de Morfologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil / Universidade Federal do Rio Grande do Norte. Programas de Pós-Graduação em Ciências da Saúde e Ciências Farmacêuticas. Natal, RN, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.We have previously demonstrated selection favoring the JG strain of Trypanosoma cruzi in hearts of BALB/c mice that were chronically infected with an equal mixture of the monoclonal JG strain and a clone of the Colombian strain, Col1.7G2. To evaluate whether cell invasion efficiency drives this selection, we infected primary cultures of BALB/c cardiomyocytes using these same T. cruzi populations. Contrary to expectation, Col1.7G2 parasites invaded heart cell cultures in higher numbers than JG parasites; however, intracellular multiplication of JG parasites was more efficient than that of Col1.7G2 parasites. This phenomenon was only observed for cardiomyocytes and not for cultured Vero cells. Double infections (Col1.7G2 + JG) showed similar results. Even though invasion might influence tissue selection, our data strongly suggest that intracellular development is important to determine parasite tissue tropism.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28005/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmarianazarer2_meirelles_etal_IOC_2010.pdfmarianazarer2_meirelles_etal_IOC_2010.pdfapplication/pdf728616https://www.arca.fiocruz.br/bitstream/icict/28005/2/marianazarer2_meirelles_etal_IOC_2010.pdf4f54ae11222660f25299fcb78d0b59b2MD52TEXTmarianazarer2_meirelles_etal_IOC_2010.pdf.txtmarianazarer2_meirelles_etal_IOC_2010.pdf.txtExtracted texttext/plain20669https://www.arca.fiocruz.br/bitstream/icict/28005/3/marianazarer2_meirelles_etal_IOC_2010.pdf.txtd891ee7548a5aa67fa377f024149fdebMD53icict/280052018-08-15 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dc.title.pt_BR.fl_str_mv Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study
title Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study
spellingShingle Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study
Andrade, Luciana O.
Trypanosoma Cruzi
Doença de Chagas
tropismo tecidual
cardiomiócitos
Trypanosoma Cruzi
Chagas Disease
tissue tropism
cardiomyocytes
title_short Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study
title_full Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study
title_fullStr Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study
title_full_unstemmed Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study
title_sort Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study
author Andrade, Luciana O.
author_facet Andrade, Luciana O.
Galvão, Lúcia M. C.
Meirelles, Maria de Nazareth S. L.
Chiari, Egler
Pena, Sergio D. J.
Macedo, Andrea M.
author_role author
author2 Galvão, Lúcia M. C.
Meirelles, Maria de Nazareth S. L.
Chiari, Egler
Pena, Sergio D. J.
Macedo, Andrea M.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Luciana O.
Galvão, Lúcia M. C.
Meirelles, Maria de Nazareth S. L.
Chiari, Egler
Pena, Sergio D. J.
Macedo, Andrea M.
dc.subject.other.pt_BR.fl_str_mv Trypanosoma Cruzi
Doença de Chagas
tropismo tecidual
cardiomiócitos
topic Trypanosoma Cruzi
Doença de Chagas
tropismo tecidual
cardiomiócitos
Trypanosoma Cruzi
Chagas Disease
tissue tropism
cardiomyocytes
dc.subject.en.pt_BR.fl_str_mv Trypanosoma Cruzi
Chagas Disease
tissue tropism
cardiomyocytes
description Universidade Federal de Minas Gerais. Departamento de Morfologia. Belo Horizonte, MG, Brasil.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2018-08-08T13:39:04Z
dc.date.available.fl_str_mv 2018-08-08T13:39:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Luciana O. et al. Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study. Mem Inst Oswaldo Cruz,v.105, n.6, p.834-837, Sept. 2010
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28005
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv ANDRADE, Luciana O. et al. Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study. Mem Inst Oswaldo Cruz,v.105, n.6, p.834-837, Sept. 2010
0074-0276
1678-8060
url https://www.arca.fiocruz.br/handle/icict/28005
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/28005/3/marianazarer2_meirelles_etal_IOC_2010.pdf.txt
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