Tissue tropism in parasitic diseases

Detalhes bibliográficos
Autor(a) principal: Silva Pereira, Sara
Data de Publicação: 2019
Outros Autores: Trindade, Sandra, De Niz, Mariana, Figueiredo, Luisa M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49565
Resumo: © 2019 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
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spelling Tissue tropism in parasitic diseasesNaganaParasitesSleeping sicknessTissue tropismTrypanosomes© 2019 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.Parasitic diseases, such as sleeping sickness, Chagas disease and malaria, remain a major cause of morbidity and mortality worldwide, but particularly in tropical, developing countries. Controlling these diseases requires a better understanding of host-parasite interactions, including a deep appreciation of parasite distribution in the host. The preferred accumulation of parasites in some tissues of the host has been known for many years, but recent technical advances have allowed a more systematic analysis and quantifications of such tissue tropisms. The functional consequences of tissue tropism remain poorly studied, although it has been associated with important aspects of disease, including transmission enhancement, treatment failure, relapse and clinical outcome. Here, we discuss current knowledge of tissue tropism in Trypanosoma infections in mammals, describe potential mechanisms of tissue entry, comparatively discuss relevant findings from other parasitology fields where tissue tropism has been extensively investigated, and reflect on new questions raised by recent discoveries and their potential impact on clinical treatment and disease control strategies.L.M.F. is an Investigator of the Fundação para a Ciência e Tecnologia (IF/01050/2014) and the laboratory is funded by ERC (FatTryp, ref. 771714). M.D.N. is funded by Long Term EMBO Postdoctoral fellowship ALTF 1048-2016. Publication of this work was also funded by UID/BIM/50005/2019, from Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through Fundos do Orçamento de Estado.The Royal SocietyRepositório da Universidade de LisboaSilva Pereira, SaraTrindade, SandraDe Niz, MarianaFigueiredo, Luisa M.2021-09-21T15:36:43Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49565engOpen Biol. 2019 May 31;9(5):190036. doi: 10.1098/rsob.190036. Erratum in: Open Biol. 2019 Jun 28;9(6):19012410.1098/rsob.1900362046-2441info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:09:08Zoai:repositorio.ul.pt:10451/49565Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:09:08Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Tissue tropism in parasitic diseases
title Tissue tropism in parasitic diseases
spellingShingle Tissue tropism in parasitic diseases
Silva Pereira, Sara
Nagana
Parasites
Sleeping sickness
Tissue tropism
Trypanosomes
title_short Tissue tropism in parasitic diseases
title_full Tissue tropism in parasitic diseases
title_fullStr Tissue tropism in parasitic diseases
title_full_unstemmed Tissue tropism in parasitic diseases
title_sort Tissue tropism in parasitic diseases
author Silva Pereira, Sara
author_facet Silva Pereira, Sara
Trindade, Sandra
De Niz, Mariana
Figueiredo, Luisa M.
author_role author
author2 Trindade, Sandra
De Niz, Mariana
Figueiredo, Luisa M.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Silva Pereira, Sara
Trindade, Sandra
De Niz, Mariana
Figueiredo, Luisa M.
dc.subject.por.fl_str_mv Nagana
Parasites
Sleeping sickness
Tissue tropism
Trypanosomes
topic Nagana
Parasites
Sleeping sickness
Tissue tropism
Trypanosomes
description © 2019 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2021-09-21T15:36:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49565
url http://hdl.handle.net/10451/49565
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Open Biol. 2019 May 31;9(5):190036. doi: 10.1098/rsob.190036. Erratum in: Open Biol. 2019 Jun 28;9(6):190124
10.1098/rsob.190036
2046-2441
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv The Royal Society
publisher.none.fl_str_mv The Royal Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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