Global In-Silico Scenario of tRNA Genes and Their Organization in Virus Genomes

Detalhes bibliográficos
Autor(a) principal: Morgado, Sergio
Data de Publicação: 2019
Outros Autores: Vicente, Ana Carolina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35292
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro. RJ, Brasil.
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spelling Morgado, SergioVicente, Ana Carolina2019-09-03T12:45:44Z2019-09-03T12:45:44Z2019MORGADO, Sergio; VICENTE, Ana Carolina. Global In-Silico Scenario of tRNA Genes and Their Organization in Virus Genomes. Viruses, v. 11, n. 180, 14p, Feb. 2019.1999-4915https://www.arca.fiocruz.br/handle/icict/3529210.3390/v110201801999-4915engMDPIVírusBacteriófagosEspecificidade de HospedeiroCódontRNA genetRNA gene clusterVirusBacteriophagesssRNATranslation apparatusHost rangeCodonsssDNAEspecificidade de HospedeiroAlanina-tRNA LigaseCódonGlobal In-Silico Scenario of tRNA Genes and Their Organization in Virus Genomesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro. RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro. RJ, Brasil.Viruses are known to be highly dependent on the host translation machinery for their protein synthesis. However, tRNA genes are occasionally identified in such organisms, and in addition, few of them harbor tRNA gene clusters comprising dozens of genes. Recently, tRNA gene clusters have been shown to occur among the three domains of life. In such a scenario, the viruses could play a role in the dispersion of such structures among these organisms. Thus, in order to reveal the prevalence of tRNA genes as well as tRNA gene clusters in viruses, we performed an unbiased large-scale genome survey. Interestingly, tRNA genes were predicted in ssDNA (single-stranded DNA) and ssRNA (single-stranded RNA) viruses as well in many other dsDNA viruses of families from Caudovirales order. In the latter group, tRNA gene clusters composed of 15 to 37 tRNA genes were characterized, mainly in bacteriophages, enlarging the occurrence of such structures within viruses. These bacteriophages were from hosts that encompass five phyla and 34 genera. This in-silico study presents the current global scenario of tRNA genes and their organization in virus genomes, contributing and opening questions to be explored in further studies concerning the role of the translation apparatus in these organisms.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35292/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSergioMorgado_ANAVicente_IOC_2019.pdfSergioMorgado_ANAVicente_IOC_2019.pdfapplication/pdf3320391https://www.arca.fiocruz.br/bitstream/icict/35292/2/SergioMorgado_ANAVicente_IOC_2019.pdffa70305b10318fc6f18966ab1a28ac63MD52TEXTSergioMorgado_ANAVicente_IOC_2019.pdf.txtSergioMorgado_ANAVicente_IOC_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Global In-Silico Scenario of tRNA Genes and Their Organization in Virus Genomes
title Global In-Silico Scenario of tRNA Genes and Their Organization in Virus Genomes
spellingShingle Global In-Silico Scenario of tRNA Genes and Their Organization in Virus Genomes
Morgado, Sergio
Vírus
Bacteriófagos
Especificidade de Hospedeiro
Códon
tRNA gene
tRNA gene cluster
Virus
Bacteriophages
ssRNA
Translation apparatus
Host range
Codons
ssDNA
Especificidade de Hospedeiro
Alanina-tRNA Ligase
Códon
title_short Global In-Silico Scenario of tRNA Genes and Their Organization in Virus Genomes
title_full Global In-Silico Scenario of tRNA Genes and Their Organization in Virus Genomes
title_fullStr Global In-Silico Scenario of tRNA Genes and Their Organization in Virus Genomes
title_full_unstemmed Global In-Silico Scenario of tRNA Genes and Their Organization in Virus Genomes
title_sort Global In-Silico Scenario of tRNA Genes and Their Organization in Virus Genomes
author Morgado, Sergio
author_facet Morgado, Sergio
Vicente, Ana Carolina
author_role author
author2 Vicente, Ana Carolina
author2_role author
dc.contributor.author.fl_str_mv Morgado, Sergio
Vicente, Ana Carolina
dc.subject.other.pt_BR.fl_str_mv Vírus
Bacteriófagos
Especificidade de Hospedeiro
Códon
topic Vírus
Bacteriófagos
Especificidade de Hospedeiro
Códon
tRNA gene
tRNA gene cluster
Virus
Bacteriophages
ssRNA
Translation apparatus
Host range
Codons
ssDNA
Especificidade de Hospedeiro
Alanina-tRNA Ligase
Códon
dc.subject.en.pt_BR.fl_str_mv tRNA gene
tRNA gene cluster
Virus
Bacteriophages
ssRNA
Translation apparatus
Host range
Codons
ssDNA
dc.subject.decs.pt_BR.fl_str_mv Especificidade de Hospedeiro
Alanina-tRNA Ligase
Códon
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro. RJ, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-09-03T12:45:44Z
dc.date.available.fl_str_mv 2019-09-03T12:45:44Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MORGADO, Sergio; VICENTE, Ana Carolina. Global In-Silico Scenario of tRNA Genes and Their Organization in Virus Genomes. Viruses, v. 11, n. 180, 14p, Feb. 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35292
dc.identifier.issn.pt_BR.fl_str_mv 1999-4915
dc.identifier.doi.none.fl_str_mv 10.3390/v11020180
dc.identifier.eissn.none.fl_str_mv 1999-4915
identifier_str_mv MORGADO, Sergio; VICENTE, Ana Carolina. Global In-Silico Scenario of tRNA Genes and Their Organization in Virus Genomes. Viruses, v. 11, n. 180, 14p, Feb. 2019.
1999-4915
10.3390/v11020180
url https://www.arca.fiocruz.br/handle/icict/35292
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/35292/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/35292/2/SergioMorgado_ANAVicente_IOC_2019.pdf
https://www.arca.fiocruz.br/bitstream/icict/35292/3/SergioMorgado_ANAVicente_IOC_2019.pdf.txt
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