Human retrovirus codon usage from tRNA point of view: therapeutic insights

Detalhes bibliográficos
Autor(a) principal: Frias, Diego
Data de Publicação: 2013
Outros Autores: Cunha, Joana P. Monteiro, Miranda, Aline C. Mota, Fonseca, Vagner S., Oliveira, Tulio de, Castro, Bernardo Galvão, Alcântara, Luiz Carlos Júnior
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15554
Resumo: p. 335–345
id UFBA-2_8bc77519d88c6b0fb6ee7a2a2bddfae5
oai_identifier_str oai:repositorio.ufba.br:ri/15554
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Frias, DiegoCunha, Joana P. MonteiroMiranda, Aline C. MotaFonseca, Vagner S.Oliveira, Tulio deCastro, Bernardo GalvãoAlcântara, Luiz Carlos JúniorFrias, DiegoCunha, Joana P. MonteiroMiranda, Aline C. MotaFonseca, Vagner S.Oliveira, Tulio deCastro, Bernardo GalvãoAlcântara, Luiz Carlos Júnior2014-08-11T19:09:20Z2014-08-11T19:09:20Z20131177-9322http://repositorio.ufba.br/ri/handle/ri/15554v. 7p. 335–345The purpose of this study was to investigate the balance between transfer ribonucleic acid (tRNA) supply and demand in retrovirus-infected cells, seeking the best targets for antiretroviral therapy based on the hypothetical tRNA Inhibition Therapy (TRIT). Codon usage and tRNA gene data were retrieved from public databases. Based on logistic principles, a therapeutic score (T-score) was calculated for all sense codons, in each retrovirus-host system. Codons that are critical for viral protein translation, but not as critical for the host, have the highest T-score values. Theoretically, inactivating the cognate tRNA species should imply a severe reduction of the elongation rate during viral mRNA translation. We developed a method to predict tRNA species critical for retroviral protein synthesis. Four of the best TRIT targets in HIV-1 and HIV-2 encode Large Hydrophobic Residues (LHR), which have a central role in protein folding. One of them, codon CUA, is also a TRIT target in both HTLV-1 and HTLV-2. Therefore, a drug designed for inactivating or reducing the cytoplasmatic concentration of tRNA species with anticodon TAG could attenuate significantly both HIV and HTLV protein synthesis rates. Inversely, replacing codons ending in UA by synonymous codons should increase the expression, which is relevant for DNA vaccine design.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-22T16:21:32Z No. of bitstreams: 1 10.4137BBI.S12093.pdf: 1564997 bytes, checksum: f165a32def8564d25b1536d70bad953f (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-08-11T19:09:20Z (GMT) No. of bitstreams: 1 10.4137BBI.S12093.pdf: 1564997 bytes, checksum: f165a32def8564d25b1536d70bad953f (MD5)Made available in DSpace on 2014-08-11T19:09:20Z (GMT). No. of bitstreams: 1 10.4137BBI.S12093.pdf: 1564997 bytes, checksum: f165a32def8564d25b1536d70bad953f (MD5) Previous issue date: 2013http://dx.doi.org/10.4137/BBI.S12093reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACodon usagetRNAHIVHTLVTherapyHuman retrovirus codon usage from tRNA point of view: therapeutic insightsBioinformatics and Biology Insightsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15554/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINAL10.4137BBI.S12093.pdf10.4137BBI.S12093.pdfapplication/pdf1564997https://repositorio.ufba.br/bitstream/ri/15554/1/10.4137BBI.S12093.pdff165a32def8564d25b1536d70bad953fMD51TEXT10.4137BBI.S12093.pdf.txt10.4137BBI.S12093.pdf.txtExtracted texttext/plain43637https://repositorio.ufba.br/bitstream/ri/15554/3/10.4137BBI.S12093.pdf.txt61b1d1eededd238835c25013ce49932fMD53ri/155542022-07-05 14:02:55.049oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:55Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Human retrovirus codon usage from tRNA point of view: therapeutic insights
dc.title.alternative.pt_BR.fl_str_mv Bioinformatics and Biology Insights
title Human retrovirus codon usage from tRNA point of view: therapeutic insights
spellingShingle Human retrovirus codon usage from tRNA point of view: therapeutic insights
Frias, Diego
Codon usage
tRNA
HIV
HTLV
Therapy
title_short Human retrovirus codon usage from tRNA point of view: therapeutic insights
title_full Human retrovirus codon usage from tRNA point of view: therapeutic insights
title_fullStr Human retrovirus codon usage from tRNA point of view: therapeutic insights
title_full_unstemmed Human retrovirus codon usage from tRNA point of view: therapeutic insights
title_sort Human retrovirus codon usage from tRNA point of view: therapeutic insights
author Frias, Diego
author_facet Frias, Diego
Cunha, Joana P. Monteiro
Miranda, Aline C. Mota
Fonseca, Vagner S.
Oliveira, Tulio de
Castro, Bernardo Galvão
Alcântara, Luiz Carlos Júnior
author_role author
author2 Cunha, Joana P. Monteiro
Miranda, Aline C. Mota
Fonseca, Vagner S.
Oliveira, Tulio de
Castro, Bernardo Galvão
Alcântara, Luiz Carlos Júnior
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Frias, Diego
Cunha, Joana P. Monteiro
Miranda, Aline C. Mota
Fonseca, Vagner S.
Oliveira, Tulio de
Castro, Bernardo Galvão
Alcântara, Luiz Carlos Júnior
Frias, Diego
Cunha, Joana P. Monteiro
Miranda, Aline C. Mota
Fonseca, Vagner S.
Oliveira, Tulio de
Castro, Bernardo Galvão
Alcântara, Luiz Carlos Júnior
dc.subject.por.fl_str_mv Codon usage
tRNA
HIV
HTLV
Therapy
topic Codon usage
tRNA
HIV
HTLV
Therapy
description p. 335–345
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-08-11T19:09:20Z
dc.date.available.fl_str_mv 2014-08-11T19:09:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15554
dc.identifier.issn.none.fl_str_mv 1177-9322
dc.identifier.number.pt_BR.fl_str_mv v. 7
identifier_str_mv 1177-9322
v. 7
url http://repositorio.ufba.br/ri/handle/ri/15554
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.4137/BBI.S12093
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/15554/2/license.txt
https://repositorio.ufba.br/bitstream/ri/15554/1/10.4137BBI.S12093.pdf
https://repositorio.ufba.br/bitstream/ri/15554/3/10.4137BBI.S12093.pdf.txt
bitstream.checksum.fl_str_mv 0d4b811ef71182510d2015daa7c8a900
f165a32def8564d25b1536d70bad953f
61b1d1eededd238835c25013ce49932f
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459476117749760

Registros relacionados