Myocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy

Detalhes bibliográficos
Autor(a) principal: Andrade, Zilton de Araújo
Data de Publicação: 1994
Outros Autores: Andrade, Sonia Gumes, Correa, Rosaly, Sadigursky, Moysés, Ferrans, Victor J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5701
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Andrade, Zilton de AraújoAndrade, Sonia GumesCorrea, RosalySadigursky, MoysésFerrans, Victor J.2012-10-19T21:29:50Z2012-10-19T21:29:50Z1994ANDRADE, Z.A. et al. Myocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy. American Journal of Pathology, v. 144, n. 6, p. 1403-11, jun. 1994.0002-9440https://www.arca.fiocruz.br/handle/icict/5701engMyocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilNational Heart Lung and Blood Institut. National Institute of Health. Bethesda, MarylandFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilNational Heart Lung and Blood Institut. National Institute of Health. Bethesda, MarylandHistological and ultrastructural studies of the hearts of dogs sacrificed 18 to 26 days after intraperitoneal inoculation with 4 x 10(5) blood forms of the 12 SF strain of Trypanosoma cruzi/kg of body weight disclosed myocarditis characterized by parasitic invasion of some myocytes, damage and necrosis of nonparasitized myocytes, and interstitial infiltration by mononuclear cells. Nonparasitized myocytes showed alterations ranging from mild edema to severe myocytolysis. These changes often were accompanied by contacts of myocytes with lymphocytes (both granular and agranular) and macrophages. These contacts were characterized by focal loss of the myocyte basement membrane and close approximation of the plasma membranes of the two cells. Contacts between lymphocytes and capillary endothelial cells were also frequent. Platelet aggregates and fibrin microthrombi were observed in some capillaries. Our findings suggest that immune effector cells play a major role in the pathogenesis of the myocyte damage and the microangiopathy in acute Chagas' disease.Cardiomiopatia Chagásica/patologiaVasos Coronários/patologiaCoração/parasitologiaMiocárdio/patologiaMiocárdio/ultraestruturaTrypanosoma cruzi/ultraestruturaAnimaisComunicação CelularCardiomiopatia Chagásica/imunologiaCãesEndotélio Vascular/patologiaEndotélio Vascular/ultraestruturaLinfócitos/patologiaLinfócitos/ultraestruturaMacrófagos/patologiaMacrófagos/ultraestruturaMicrocirculaçãoMicroscopia EletrônicaNecroseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade ZA Myocardial changes in acute....pdfAndrade ZA Myocardial changes in acute....pdfapplication/pdf3779330https://www.arca.fiocruz.br/bitstream/icict/5701/1/Andrade%20ZA%20Myocardial%20changes%20in%20acute....pdf2401ed749cc9ecec24813c04ed72a80fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5701/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTAndrade ZA Myocardial changes in acute....pdf.txtAndrade ZA Myocardial changes in acute....pdf.txtExtracted texttext/plain31877https://www.arca.fiocruz.br/bitstream/icict/5701/5/Andrade%20ZA%20Myocardial%20changes%20in%20acute....pdf.txt76baf337218631af809e1a69bcc8979fMD55THUMBNAILAndrade ZA Myocardial changes in acute....pdf.jpgAndrade ZA Myocardial changes in acute....pdf.jpgGenerated Thumbnailimage/jpeg2549https://www.arca.fiocruz.br/bitstream/icict/5701/4/Andrade%20ZA%20Myocardial%20changes%20in%20acute....pdf.jpgc308504fdc028eb3e6c4b025844ef190MD54icict/57012023-03-15 14:33:13.994oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:13Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Myocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy
title Myocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy
spellingShingle Myocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy
Andrade, Zilton de Araújo
Cardiomiopatia Chagásica/patologia
Vasos Coronários/patologia
Coração/parasitologia
Miocárdio/patologia
Miocárdio/ultraestrutura
Trypanosoma cruzi/ultraestrutura
Animais
Comunicação Celular
Cardiomiopatia Chagásica/imunologia
Cães
Endotélio Vascular/patologia
Endotélio Vascular/ultraestrutura
Linfócitos/patologia
Linfócitos/ultraestrutura
Macrófagos/patologia
Macrófagos/ultraestrutura
Microcirculação
Microscopia Eletrônica
Necrose
title_short Myocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy
title_full Myocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy
title_fullStr Myocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy
title_full_unstemmed Myocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy
title_sort Myocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy
author Andrade, Zilton de Araújo
author_facet Andrade, Zilton de Araújo
Andrade, Sonia Gumes
Correa, Rosaly
Sadigursky, Moysés
Ferrans, Victor J.
author_role author
author2 Andrade, Sonia Gumes
Correa, Rosaly
Sadigursky, Moysés
Ferrans, Victor J.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Zilton de Araújo
Andrade, Sonia Gumes
Correa, Rosaly
Sadigursky, Moysés
Ferrans, Victor J.
dc.subject.decs.pt_BR.fl_str_mv Cardiomiopatia Chagásica/patologia
Vasos Coronários/patologia
Coração/parasitologia
Miocárdio/patologia
Miocárdio/ultraestrutura
Trypanosoma cruzi/ultraestrutura
Animais
Comunicação Celular
Cardiomiopatia Chagásica/imunologia
Cães
Endotélio Vascular/patologia
Endotélio Vascular/ultraestrutura
Linfócitos/patologia
Linfócitos/ultraestrutura
Macrófagos/patologia
Macrófagos/ultraestrutura
Microcirculação
Microscopia Eletrônica
Necrose
topic Cardiomiopatia Chagásica/patologia
Vasos Coronários/patologia
Coração/parasitologia
Miocárdio/patologia
Miocárdio/ultraestrutura
Trypanosoma cruzi/ultraestrutura
Animais
Comunicação Celular
Cardiomiopatia Chagásica/imunologia
Cães
Endotélio Vascular/patologia
Endotélio Vascular/ultraestrutura
Linfócitos/patologia
Linfócitos/ultraestrutura
Macrófagos/patologia
Macrófagos/ultraestrutura
Microcirculação
Microscopia Eletrônica
Necrose
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1994
dc.date.issued.fl_str_mv 1994
dc.date.accessioned.fl_str_mv 2012-10-19T21:29:50Z
dc.date.available.fl_str_mv 2012-10-19T21:29:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Z.A. et al. Myocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy. American Journal of Pathology, v. 144, n. 6, p. 1403-11, jun. 1994.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5701
dc.identifier.issn.none.fl_str_mv 0002-9440
identifier_str_mv ANDRADE, Z.A. et al. Myocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy. American Journal of Pathology, v. 144, n. 6, p. 1403-11, jun. 1994.
0002-9440
url https://www.arca.fiocruz.br/handle/icict/5701
dc.language.iso.fl_str_mv eng
language eng
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