Effects of human papillomavirus-associated cells on human immunodeficiency virus gene expression

Detalhes bibliográficos
Autor(a) principal: Gage, J. R.
Data de Publicação: 2000
Outros Autores: Sandhu, A. K., Nihira, M., Bonecini-Almeida, M. da G., Cristoforoni, P., Kishimoto, T., Montz, F. J., Martínez-Maza, O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33521
Resumo: Maria da Glória Bonecini-Almeida. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Gage, J. R.Sandhu, A. K.Nihira, M.Bonecini-Almeida, M. da G.Cristoforoni, P.Kishimoto, T.Montz, F. J.Martínez-Maza, O.2019-06-17T14:34:48Z2019-06-17T14:34:48Z2000GAGE, J. R. et al. Effects of human papillomavirus-associated cells on human immunodeficiency virus gene expression. Obstetrics and Ginecology, v. 96, n. 6, p. 879-885, Dec. 2000.0029-7844https://www.arca.fiocruz.br/handle/icict/3352110.1016/S0029-7844(00)01057-7Maria da Glória Bonecini-Almeida. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2020-06-17University of California, Los Angeles. School of Medicine. Department of Obstetrics and Gynecology. Los Angeles, CA, USA.Sem afiliação.Sem afiliação.Sem afiliação.Sem afiliação.Sem afiliação.Sem afiliação.Sem afiliação.Objective: To examine the effects of soluble factors secretedby human papillomavirus (HPV)-associated cells on humanimmunodeficiency virus (HIV) expression.Methods: Supernatants collected from cultured cervicalbiopsies and cervical cancer cell lines, and HPV-immortalized and normal keratinocytes were tested for theability to induce HIV p24 production in two cell lines thatcontained latent HIV (the U1 monocytic line and the ACH-2T cell line). Levels of HIV p24 were measured by enzyme-linked immunosorbent assay (ELISA). Culture supernatantswere also assayed for the inflammatory cytokines interleu-kin 6, tumor necrosis factor, and interleukin 1bby ELISA.Results: Supernatants from all epithelial cells tested up-regulated HIV p24 expression in the U1 line but not in theACH-2 cells. Only differentiated normal keratinocytes in-duced p24 production by ACH-2 cells. Neutralization of thecytokines, particularly interleukin 6, partially reduced thelevel of HIV-inducing activity in the culture supernatants.Additionally, cervical biopsies from HIV-infected womencultured in vitro also were able to induce HIV in U1 cells butnot ACH-2 cells.Conclusions: Our results suggest that HPV infection of thecervix might influence HIV pathogenesis by inducing theproduction of immune and inflammatory factors that en-hance HIV expression.engLippincott, Williams & WilkinsEffects of human papillomavirus-associated cells on human immunodeficiency virus gene expressioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHPVHIVGene expressioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Effects of human papillomavirus-associated cells on human immunodeficiency virus gene expression
title Effects of human papillomavirus-associated cells on human immunodeficiency virus gene expression
spellingShingle Effects of human papillomavirus-associated cells on human immunodeficiency virus gene expression
Gage, J. R.
HPV
HIV
Gene expression
title_short Effects of human papillomavirus-associated cells on human immunodeficiency virus gene expression
title_full Effects of human papillomavirus-associated cells on human immunodeficiency virus gene expression
title_fullStr Effects of human papillomavirus-associated cells on human immunodeficiency virus gene expression
title_full_unstemmed Effects of human papillomavirus-associated cells on human immunodeficiency virus gene expression
title_sort Effects of human papillomavirus-associated cells on human immunodeficiency virus gene expression
author Gage, J. R.
author_facet Gage, J. R.
Sandhu, A. K.
Nihira, M.
Bonecini-Almeida, M. da G.
Cristoforoni, P.
Kishimoto, T.
Montz, F. J.
Martínez-Maza, O.
author_role author
author2 Sandhu, A. K.
Nihira, M.
Bonecini-Almeida, M. da G.
Cristoforoni, P.
Kishimoto, T.
Montz, F. J.
Martínez-Maza, O.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gage, J. R.
Sandhu, A. K.
Nihira, M.
Bonecini-Almeida, M. da G.
Cristoforoni, P.
Kishimoto, T.
Montz, F. J.
Martínez-Maza, O.
dc.subject.en.pt_BR.fl_str_mv HPV
HIV
Gene expression
topic HPV
HIV
Gene expression
description Maria da Glória Bonecini-Almeida. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2000
dc.date.issued.fl_str_mv 2000
dc.date.accessioned.fl_str_mv 2019-06-17T14:34:48Z
dc.date.available.fl_str_mv 2019-06-17T14:34:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GAGE, J. R. et al. Effects of human papillomavirus-associated cells on human immunodeficiency virus gene expression. Obstetrics and Ginecology, v. 96, n. 6, p. 879-885, Dec. 2000.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33521
dc.identifier.issn.pt_BR.fl_str_mv 0029-7844
dc.identifier.doi.none.fl_str_mv 10.1016/S0029-7844(00)01057-7
identifier_str_mv GAGE, J. R. et al. Effects of human papillomavirus-associated cells on human immunodeficiency virus gene expression. Obstetrics and Ginecology, v. 96, n. 6, p. 879-885, Dec. 2000.
0029-7844
10.1016/S0029-7844(00)01057-7
url https://www.arca.fiocruz.br/handle/icict/33521
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins
publisher.none.fl_str_mv Lippincott, Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/33521/1/license.txt
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