Unbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Silva, Icaro Bonyek
Data de Publicação: 2020
Outros Autores: Nunes, Sara, Santos, Reinan L., Lima, Filipe R., Lago, Alexsandro, Silva, Juliana, Carvalho, Lucas pedreira de, Arruda, Sergio Marcos, Serezani, Henrique C., Carvalho, Edgar Marcelino, Brodskyn, Claudia Ida, Tavares, Natalia M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43318
Resumo: [Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) #1] under Grant [number PET0009/2016]; and [Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brazil (CAPES) #2] under Finance [Code 001].
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spelling Silva, Icaro BonyekNunes, SaraSantos, Reinan L.Lima, Filipe R.Lago, AlexsandroSilva, JulianaCarvalho, Lucas pedreira deArruda, Sergio MarcosSerezani, Henrique C.Carvalho, Edgar MarcelinoBrodskyn, Claudia IdaTavares, Natalia M.2020-09-11T13:15:13Z2020-09-11T13:15:13Z2020SILVA, Icaro Bonyek et al. Unbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis. Emerging Microbes & Infections, 2020.2222-1751https://www.arca.fiocruz.br/handle/icict/43318[Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) #1] under Grant [number PET0009/2016]; and [Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brazil (CAPES) #2] under Finance [Code 001].Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA.Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil /National Institute of Science and Technology in Tropical Diseases. Salvador, BA, Brazil.Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil /National Institute of Science and Technology. Institute of Investigation in Immunology. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil /National Institute of Science and Technology. Institute of Investigation in Immunology. São Paulo, SP, Brazil.Poorly controlled diabetes mellitus leads to several comorbidities, including susceptibility to infections. Hyperglycemia increases phagocyte responsiveness, however immune cells from people with diabetes show inadequate antimicrobial functions. We and others have shown that aberrant production of leukotriene B4 (LTB4) is detrimental to host defense in models of bacterial infection. Here, we will unveil the consequences of high glucose in the outcome of Leishmania braziliensis skin infection in people with diabetes and determine the role of LTB4 in human phagocytes. We show that diabetes leads to higher systemic levels of LTB4, IL-6 and TNF-α in cutaneous leishmaniasis. Only LTB4 correlated with blood glucose levels and healing time in diabetes comorbidity. Skin lesions of people with leishmaniasis and diabetes exhibit increased neutrophil and amastigote numbers. Monocyte-derived macrophages from these individuals showed higher L. braziliensis loads, reduced production of Reactive Oxygen Species and unbalanced LTB4/PGE2 ratio. Our data reveal a systemic inflammation driven by diabetes comorbidity in opposition to a local reduced capacity to resolve L. braziliensis infection and a worse disease outcomeengTaylor & FrancisDiabetesLeishmaniose humanaLeishmania braziliensisMediadores lipídicosLTB4PGE2DiabetesHuman leishmaniasisLeishmania braziliensisLipid mediatorsLTB4PGE2Unbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43318/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSilva, I.B.S. Unbalanced....pdfSilva, I.B.S. 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dc.title.pt_BR.fl_str_mv Unbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis
title Unbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis
spellingShingle Unbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis
Silva, Icaro Bonyek
Diabetes
Leishmaniose humana
Leishmania braziliensis
Mediadores lipídicos
LTB4
PGE2
Diabetes
Human leishmaniasis
Leishmania braziliensis
Lipid mediators
LTB4
PGE2
title_short Unbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis
title_full Unbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis
title_fullStr Unbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis
title_full_unstemmed Unbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis
title_sort Unbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis
author Silva, Icaro Bonyek
author_facet Silva, Icaro Bonyek
Nunes, Sara
Santos, Reinan L.
Lima, Filipe R.
Lago, Alexsandro
Silva, Juliana
Carvalho, Lucas pedreira de
Arruda, Sergio Marcos
Serezani, Henrique C.
Carvalho, Edgar Marcelino
Brodskyn, Claudia Ida
Tavares, Natalia M.
author_role author
author2 Nunes, Sara
Santos, Reinan L.
Lima, Filipe R.
Lago, Alexsandro
Silva, Juliana
Carvalho, Lucas pedreira de
Arruda, Sergio Marcos
Serezani, Henrique C.
Carvalho, Edgar Marcelino
Brodskyn, Claudia Ida
Tavares, Natalia M.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Icaro Bonyek
Nunes, Sara
Santos, Reinan L.
Lima, Filipe R.
Lago, Alexsandro
Silva, Juliana
Carvalho, Lucas pedreira de
Arruda, Sergio Marcos
Serezani, Henrique C.
Carvalho, Edgar Marcelino
Brodskyn, Claudia Ida
Tavares, Natalia M.
dc.subject.other.pt_BR.fl_str_mv Diabetes
Leishmaniose humana
Leishmania braziliensis
Mediadores lipídicos
LTB4
PGE2
topic Diabetes
Leishmaniose humana
Leishmania braziliensis
Mediadores lipídicos
LTB4
PGE2
Diabetes
Human leishmaniasis
Leishmania braziliensis
Lipid mediators
LTB4
PGE2
dc.subject.en.pt_BR.fl_str_mv Diabetes
Human leishmaniasis
Leishmania braziliensis
Lipid mediators
LTB4
PGE2
description [Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) #1] under Grant [number PET0009/2016]; and [Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brazil (CAPES) #2] under Finance [Code 001].
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-09-11T13:15:13Z
dc.date.available.fl_str_mv 2020-09-11T13:15:13Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Icaro Bonyek et al. Unbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis. Emerging Microbes & Infections, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43318
dc.identifier.issn.pt_BR.fl_str_mv 2222-1751
identifier_str_mv SILVA, Icaro Bonyek et al. Unbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis. Emerging Microbes & Infections, 2020.
2222-1751
url https://www.arca.fiocruz.br/handle/icict/43318
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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