Cell therapy in Chagas Disease

Detalhes bibliográficos
Autor(a) principal: Carvalho, Antonio Carlos Campos de
Data de Publicação: 2009
Outros Autores: Goldenberg, Regina Coeli dos Santos, Jelicks, Linda A, Soares, Milena Botelho Pereira, Santos, Ricardo Ribeiro dos, Spray, David Conover, Tanowitz, Herbert Bernard
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9902
Resumo: Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Albert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NY, USA / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil
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spelling Carvalho, Antonio Carlos Campos deGoldenberg, Regina Coeli dos SantosJelicks, Linda ASoares, Milena Botelho PereiraSantos, Ricardo Ribeiro dosSpray, David ConoverTanowitz, Herbert Bernard2015-04-06T18:20:03Z2015-04-06T18:20:03Z2009CARVALHO, A. C. C. etal. Cell therapy in Chagas Disease. Interdisciplinary Perspectives on Infectious Diseases, p. 484358-6, 2009.1687-708Xhttps://www.arca.fiocruz.br/handle/icict/990210.1155/2009/484358engHindawi Publishing CorporationDoença de chagasTrypanosoma cruziCardiomiopatiaAmerica LatinaMiocardiopatia chagásicaCirurgiaTransplante de célulasTransplante da medula ósseaAnimaisCell therapy in Chagas Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Albert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NY, USA / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilAlbert Einstein College of Medicine. Department of Physiology & Biophysics. Bronx, NY, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilAlbert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NY, USAAlbert Einstein College of Medicine. Department of Pathology. Bronx, NY, USAChagas disease which is caused by the parasite Trypanosoma cruzi is an important cause of cardiomyopathy in Latin America. In later stages chagasic cardiomyopathy is associated with congestive heart failure which is often refractory to medical therapy. In these individuals heart transplantation has been attempted. However, this procedure is fraught with many problems attributable to the surgery and the postsurgical administration of immunosuppressive drugs. Studies inmice suggest that the transplantation of bone-marrow-derived cells ameliorates the inflammation and fibrosis in the heart associated with this infection. Cardiac magnetic resonance imaging reveals that bone marrow transplantation ameliorates the infection induced right ventricular enlargement. On the basis of these animal studies the safety of autologous bone marrow transplantation has been assessed in patients with chagasic end-stage heart disease. The initial results are encouraging and more studies need to be performed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/9902/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALCarvalho ACC Cell therapy....pdfCarvalho ACC Cell therapy....pdfapplication/pdf2011368https://www.arca.fiocruz.br/bitstream/icict/9902/2/Carvalho%20ACC%20Cell%20therapy....pdf96e667a445f290613eb26230a2bf7069MD52TEXTCarvalho ACC Cell therapy....pdf.txtCarvalho ACC Cell therapy....pdf.txtExtracted texttext/plain33268https://www.arca.fiocruz.br/bitstream/icict/9902/3/Carvalho%20ACC%20Cell%20therapy....pdf.txtb2f58db5484381512ce644f08d14052bMD53icict/99022023-03-15 14:33:09.615oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:09Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Cell therapy in Chagas Disease
title Cell therapy in Chagas Disease
spellingShingle Cell therapy in Chagas Disease
Carvalho, Antonio Carlos Campos de
Doença de chagas
Trypanosoma cruzi
Cardiomiopatia
America Latina
Miocardiopatia chagásica
Cirurgia
Transplante de células
Transplante da medula óssea
Animais
title_short Cell therapy in Chagas Disease
title_full Cell therapy in Chagas Disease
title_fullStr Cell therapy in Chagas Disease
title_full_unstemmed Cell therapy in Chagas Disease
title_sort Cell therapy in Chagas Disease
author Carvalho, Antonio Carlos Campos de
author_facet Carvalho, Antonio Carlos Campos de
Goldenberg, Regina Coeli dos Santos
Jelicks, Linda A
Soares, Milena Botelho Pereira
Santos, Ricardo Ribeiro dos
Spray, David Conover
Tanowitz, Herbert Bernard
author_role author
author2 Goldenberg, Regina Coeli dos Santos
Jelicks, Linda A
Soares, Milena Botelho Pereira
Santos, Ricardo Ribeiro dos
Spray, David Conover
Tanowitz, Herbert Bernard
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Antonio Carlos Campos de
Goldenberg, Regina Coeli dos Santos
Jelicks, Linda A
Soares, Milena Botelho Pereira
Santos, Ricardo Ribeiro dos
Spray, David Conover
Tanowitz, Herbert Bernard
dc.subject.other.pt_BR.fl_str_mv Doença de chagas
Trypanosoma cruzi
Cardiomiopatia
America Latina
Miocardiopatia chagásica
Cirurgia
Transplante de células
Transplante da medula óssea
Animais
topic Doença de chagas
Trypanosoma cruzi
Cardiomiopatia
America Latina
Miocardiopatia chagásica
Cirurgia
Transplante de células
Transplante da medula óssea
Animais
description Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Albert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NY, USA / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2015-04-06T18:20:03Z
dc.date.available.fl_str_mv 2015-04-06T18:20:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, A. C. C. etal. Cell therapy in Chagas Disease. Interdisciplinary Perspectives on Infectious Diseases, p. 484358-6, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9902
dc.identifier.issn.none.fl_str_mv 1687-708X
dc.identifier.doi.none.fl_str_mv 10.1155/2009/484358
identifier_str_mv CARVALHO, A. C. C. etal. Cell therapy in Chagas Disease. Interdisciplinary Perspectives on Infectious Diseases, p. 484358-6, 2009.
1687-708X
10.1155/2009/484358
url https://www.arca.fiocruz.br/handle/icict/9902
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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