Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy.

Detalhes bibliográficos
Autor(a) principal: Soares, Milena Botelho Pereira
Data de Publicação: 2007
Outros Autores: Macambira, Simone Garcia, Carvalho, Antonio Carlos Campos de, Santos, Ricardo Ribeiro dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10078
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil
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spelling Soares, Milena Botelho PereiraMacambira, Simone GarciaCarvalho, Antonio Carlos Campos deSantos, Ricardo Ribeiro dos2015-04-17T17:22:31Z2015-04-17T17:22:31Z2007SOARES, M. B. P. et al. Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy. Regenerative Medicine, v. 2, n. 3, p. 257-264, 2007.1746-076Xhttps://www.arca.fiocruz.br/handle/icict/1007810.2217/17460751.2.3.257engFuture MedicineCellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Cardiologia de Laranjeiras. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilNearly a century after its discovery, Chagas' disease, caused by the protozoan Trypanosoma cruzi, remains a major health problem in Latin America. Although efforts in transmission control have contributed to a decrease in the number of new cases, approximately a third of chronic Chagasic individuals have or will develop the symptomatic forms of the disease, mainly cardiomyopathy. Chagas' disease is a progressively debilitating disease, which, at the final stages, there are no currently available treatments other than heart transplantation. In this scenario, cellular therapy is being tested as an alternative for millions of patients with heart dysfunction due to Chagas' disease. In this article, we review the studies of cellular therapy in animal models and in patients with Chagasic cardiomyopathy and the possible mechanisms by which cellular therapy may act in this disease.CardiomyopathyCellular therapyChagas diseaseFibrosisInflammationStem cellsCardiomiopatias/terapiaTransplante de Células/métodosTransplante de Células/tendênciasDoença de Chagas/terapiaAnimaisTransplante de Medula Óssea/métodosCardiomiopatias/quimioterapiaTransplante de Células/patologiaDoença de Chagas/quimioterapiaDoença CrônicaModelos Animais de DoençasHumanosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10078/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALSoares MBP Cellular therapy....pdfSoares MBP Cellular therapy....pdfapplication/pdf1099345https://www.arca.fiocruz.br/bitstream/icict/10078/2/Soares%20MBP%20Cellular%20therapy....pdfb9cdc5c436ebb7787a5d5f669b8ef692MD52TEXTSoares MBP Cellular therapy....pdf.txtSoares MBP Cellular therapy....pdf.txtExtracted texttext/plain39194https://www.arca.fiocruz.br/bitstream/icict/10078/3/Soares%20MBP%20Cellular%20therapy....pdf.txt5bc5a9a2e220e0243b577579850567d7MD53icict/100782023-03-15 14:33:05.093oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:05Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy.
title Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy.
spellingShingle Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy.
Soares, Milena Botelho Pereira
Cardiomyopathy
Cellular therapy
Chagas disease
Fibrosis
Inflammation
Stem cells
Cardiomiopatias/terapia
Transplante de Células/métodos
Transplante de Células/tendências
Doença de Chagas/terapia
Animais
Transplante de Medula Óssea/métodos
Cardiomiopatias/quimioterapia
Transplante de Células/patologia
Doença de Chagas/quimioterapia
Doença Crônica
Modelos Animais de Doenças
Humanos
title_short Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy.
title_full Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy.
title_fullStr Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy.
title_full_unstemmed Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy.
title_sort Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy.
author Soares, Milena Botelho Pereira
author_facet Soares, Milena Botelho Pereira
Macambira, Simone Garcia
Carvalho, Antonio Carlos Campos de
Santos, Ricardo Ribeiro dos
author_role author
author2 Macambira, Simone Garcia
Carvalho, Antonio Carlos Campos de
Santos, Ricardo Ribeiro dos
author2_role author
author
author
dc.contributor.author.fl_str_mv Soares, Milena Botelho Pereira
Macambira, Simone Garcia
Carvalho, Antonio Carlos Campos de
Santos, Ricardo Ribeiro dos
dc.subject.en.pt_BR.fl_str_mv Cardiomyopathy
Cellular therapy
Chagas disease
Fibrosis
Inflammation
Stem cells
topic Cardiomyopathy
Cellular therapy
Chagas disease
Fibrosis
Inflammation
Stem cells
Cardiomiopatias/terapia
Transplante de Células/métodos
Transplante de Células/tendências
Doença de Chagas/terapia
Animais
Transplante de Medula Óssea/métodos
Cardiomiopatias/quimioterapia
Transplante de Células/patologia
Doença de Chagas/quimioterapia
Doença Crônica
Modelos Animais de Doenças
Humanos
dc.subject.decs.pt_BR.fl_str_mv Cardiomiopatias/terapia
Transplante de Células/métodos
Transplante de Células/tendências
Doença de Chagas/terapia
Animais
Transplante de Medula Óssea/métodos
Cardiomiopatias/quimioterapia
Transplante de Células/patologia
Doença de Chagas/quimioterapia
Doença Crônica
Modelos Animais de Doenças
Humanos
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2015-04-17T17:22:31Z
dc.date.available.fl_str_mv 2015-04-17T17:22:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOARES, M. B. P. et al. Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy. Regenerative Medicine, v. 2, n. 3, p. 257-264, 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10078
dc.identifier.issn.none.fl_str_mv 1746-076X
dc.identifier.doi.none.fl_str_mv 10.2217/17460751.2.3.257
identifier_str_mv SOARES, M. B. P. et al. Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy. Regenerative Medicine, v. 2, n. 3, p. 257-264, 2007.
1746-076X
10.2217/17460751.2.3.257
url https://www.arca.fiocruz.br/handle/icict/10078
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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