Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense

Bosch, Marta; Sánchez-Álvarez, Miguel; Fajardo, Alba; Kapenatovic, Ronan; Steiner, Bernhard; Dutra, Filipe; Moreira, Luciana; López, Juan Antonio; Campo, Rocio; Mari, Montserrat; Morales-Paytuví, Frederic; Tort, Olivia; Gubern, Albert; Templin, Rachel M.; Curson, James E. B.; Martel, Nick; Catelá, Cristina; Lozano, Francisco; Tebar, Fransesc; Martel, Carlos; Vásquez, Jésus; Del Pozo, Miguel A.; Sweet, Mathew J.; Bozza, Patrícia T.; Gross, Steven P.; Parton, Robert G.; Pol, Albert

Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense

Detalhes bibliográficos
Autor(a) principal:	Bosch, Marta
Data de Publicação:	2020
Outros Autores:	Sánchez-Álvarez, Miguel, Fajardo, Alba, Kapenatovic, Ronan, Steiner, Bernhard, Dutra, Filipe, Moreira, Luciana, López, Juan Antonio, Campo, Rocio, Mari, Montserrat, Morales-Paytuví, Frederic, Tort, Olivia, Gubern, Albert, Templin, Rachel M., Curson, James E. B., Martel, Nick, Catelá, Cristina, Lozano, Francisco, Tebar, Fransesc, Martel, Carlos, Vásquez, Jésus, Del Pozo, Miguel A., Sweet, Mathew J., Bozza, Patrícia T., Gross, Steven P., Parton, Robert G., Pol, Albert
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/44797
Resumo:	Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036. Barcelona, Spain / Department of Biomedical Sciences, Faculty of Medicine, Universitat de Barcelona. 08036, Barcelona, Spain.

Metadados do item

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network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
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spelling	Bosch, MartaSánchez-Álvarez, MiguelFajardo, AlbaKapenatovic, RonanSteiner, BernhardDutra, FilipeMoreira, LucianaLópez, Juan AntonioCampo, RocioMari, MontserratMorales-Paytuví, FredericTort, OliviaGubern, AlbertTemplin, Rachel M.Curson, James E. B.Martel, NickCatelá, CristinaLozano, FranciscoTebar, FransescMartel, CarlosVásquez, JésusDel Pozo, Miguel A.Sweet, Mathew J.Bozza, Patrícia T.Gross, Steven P.Parton, Robert G.Pol, Albert2020-12-10T19:09:29Z2020-12-10T19:09:29Z2020BOSCH, Marta et al. Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense. Science, v. 370, n. 6514, easy 8085, 14p, Oct. 2020.1662-811Xhttps://www.arca.fiocruz.br/handle/icict/4479710.1126/science.aay80851662-8128engScienceGotículas lipídicasLipídios de mamíferosCentros imunes inatosMetabolismo celularDefesa do hospedeiroMammalian lipid dropletsInnate immune hubsCell metabolismHost defenseMammalian lipid droplets are innate immune hubs integrating cell metabolism and host defenseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036. Barcelona, Spain / Department of Biomedical Sciences, Faculty of Medicine, Universitat de Barcelona. 08036, Barcelona, Spain.Mechanoadaptation and Caveolae Biology Laboratory, Cell and Developmental Biology Area. Centro Nacional de Investigaciones Cardiovasculares (CNIC). 28029, Madrid, Spain.Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036. Barcelona, Spain.Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, Queensland 4072, Australia / MB Centre for Inflammation and Disease Research, University of Queensland, Brisbane, Queensland 4072, Australia / Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland 4072, Australia.Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, Queensland 4072, Australia.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil..Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil..Cardiovascular Proteomics Laboratory, Vascular Pathophysiology Area, CNIC, Instituto de Salud Carlos III 28029, Madrid, Spain / Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares (CIBER-CV), Instituto de Salud Carlos III 28029, Madrid, Spain.Cardiovascular Proteomics Laboratory, Vascular Pathophysiology Area, CNIC, Instituto de Salud Carlos III 28029, Madrid, Spain.Department of Cell Death and Proliferation, Institut d'Investigacions Biomèdiques de Barcelona (IIBB)–CSIC, Barcelona, Spain / Hepatocellular Signaling and Cancer Team, IDIBAPS, 08036, Barcelona, Spain.Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, Queensland 4072, Australia / Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Queensland 4072, Australia.Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, Queensland 4072, Australia / IMB Centre for Inflammation and Disease Research, University of Queensland, Brisbane, Queensland 4072, Australia / Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland 4072, Australia..Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, Queensland 4072, Australia.Immunoreceptors of the Innate and Adaptive System Team, IDIBAPS, 08036, Barcelona, Spain.Immunoreceptors of the Innate and Adaptive System Team, IDIBAPS, 08036, Barcelona, Spain.Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036. Barcelona, Spain / Department of Biomedical Sciences, Faculty of Medicine, Universitat de Barcelona. 08036, Barcelona, Spain.Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036. Barcelona, Spain / Department of Biomedical Sciences, Faculty of Medicine, Universitat de Barcelona. 08036, Barcelona, Spain.Cardiovascular Proteomics Laboratory, Vascular Pathophysiology Area, CNIC, Instituto de Salud Carlos III 28029, Madrid, Spain / Centro de Investigación Biomédica en Red, Enfermedades Cardiovasculares (CIBER-CV), Instituto de Salud Carlos III 28029, Madrid, Spain.Mechanoadaptation and Caveolae Biology Laboratory, Cell and Developmental Biology Area. Centro Nacional de Investigaciones Cardiovasculares (CNIC). 28029, Madrid, Spain.Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, Queensland 4072, Australia / MB Centre for Inflammation and Disease Research, University of Queensland, Brisbane, Queensland 4072, Australia / Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland 4072, Australia.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil..Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA.Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, Queensland 4072, Australia / Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Queensland 4072, Australia.Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036. Barcelona, Spain / Department of Biomedical Sciences, Faculty of Medicine, Universitat de Barcelona. 08036, Barcelona, Spain / Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010, Barcelona..Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated by danger signals. In response to lipopolysaccharide (LPS), multiple host defense proteins, including interferon-inducible guanosine triphosphatases and the antimicrobial cathelicidin, assemble into complex clusters on LDs. LPS additionally promotes the physical and functional uncoupling of LDs from mitochondria, reducing fatty acid metabolism while increasing LD-bacterial contacts. Thus, LDs actively participate in mammalian innate immunity at two levels: They are both cell-autonomous organelles that organize and use immune proteins to kill intracellular pathogens as well as central players in the local and systemic metabolic adaptation to infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44797/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPatriciaBozza_MartaBosh_etal_IOC_2020.pdfPatriciaBozza_MartaBosh_etal_IOC_2020.pdfapplication/pdf3906718https://www.arca.fiocruz.br/bitstream/icict/44797/2/PatriciaBozza_MartaBosh_etal_IOC_2020.pdf55c850a4b28e03bcf9c141b5eb515d57MD52TEXTPatriciaBozza_MartaBosh_etal_IOC_2020.pdf.txtPatriciaBozza_MartaBosh_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv	Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense
title	Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense
spellingShingle	Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense Bosch, Marta Gotículas lipídicas Lipídios de mamíferos Centros imunes inatos Metabolismo celular Defesa do hospedeiro Mammalian lipid droplets Innate immune hubs Cell metabolism Host defense
title_short	Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense
title_full	Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense
title_fullStr	Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense
title_full_unstemmed	Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense
title_sort	Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense
author	Bosch, Marta
author_facet	Bosch, Marta Sánchez-Álvarez, Miguel Fajardo, Alba Kapenatovic, Ronan Steiner, Bernhard Dutra, Filipe Moreira, Luciana López, Juan Antonio Campo, Rocio Mari, Montserrat Morales-Paytuví, Frederic Tort, Olivia Gubern, Albert Templin, Rachel M. Curson, James E. B. Martel, Nick Catelá, Cristina Lozano, Francisco Tebar, Fransesc Martel, Carlos Vásquez, Jésus Del Pozo, Miguel A. Sweet, Mathew J. Bozza, Patrícia T. Gross, Steven P. Parton, Robert G. Pol, Albert
author_role	author
author2	Sánchez-Álvarez, Miguel Fajardo, Alba Kapenatovic, Ronan Steiner, Bernhard Dutra, Filipe Moreira, Luciana López, Juan Antonio Campo, Rocio Mari, Montserrat Morales-Paytuví, Frederic Tort, Olivia Gubern, Albert Templin, Rachel M. Curson, James E. B. Martel, Nick Catelá, Cristina Lozano, Francisco Tebar, Fransesc Martel, Carlos Vásquez, Jésus Del Pozo, Miguel A. Sweet, Mathew J. Bozza, Patrícia T. Gross, Steven P. Parton, Robert G. Pol, Albert
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Bosch, Marta Sánchez-Álvarez, Miguel Fajardo, Alba Kapenatovic, Ronan Steiner, Bernhard Dutra, Filipe Moreira, Luciana López, Juan Antonio Campo, Rocio Mari, Montserrat Morales-Paytuví, Frederic Tort, Olivia Gubern, Albert Templin, Rachel M. Curson, James E. B. Martel, Nick Catelá, Cristina Lozano, Francisco Tebar, Fransesc Martel, Carlos Vásquez, Jésus Del Pozo, Miguel A. Sweet, Mathew J. Bozza, Patrícia T. Gross, Steven P. Parton, Robert G. Pol, Albert
dc.subject.other.pt_BR.fl_str_mv	Gotículas lipídicas Lipídios de mamíferos Centros imunes inatos Metabolismo celular Defesa do hospedeiro
topic	Gotículas lipídicas Lipídios de mamíferos Centros imunes inatos Metabolismo celular Defesa do hospedeiro Mammalian lipid droplets Innate immune hubs Cell metabolism Host defense
dc.subject.en.pt_BR.fl_str_mv	Mammalian lipid droplets Innate immune hubs Cell metabolism Host defense
description	Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036. Barcelona, Spain / Department of Biomedical Sciences, Faculty of Medicine, Universitat de Barcelona. 08036, Barcelona, Spain.
publishDate	2020
dc.date.accessioned.fl_str_mv	2020-12-10T19:09:29Z
dc.date.available.fl_str_mv	2020-12-10T19:09:29Z
dc.date.issued.fl_str_mv	2020
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	BOSCH, Marta et al. Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense. Science, v. 370, n. 6514, easy 8085, 14p, Oct. 2020.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/44797
dc.identifier.issn.pt_BR.fl_str_mv	1662-811X
dc.identifier.doi.none.fl_str_mv	10.1126/science.aay8085
dc.identifier.eissn.none.fl_str_mv	1662-8128
identifier_str_mv	BOSCH, Marta et al. Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense. Science, v. 370, n. 6514, easy 8085, 14p, Oct. 2020. 1662-811X 10.1126/science.aay8085 1662-8128
url	https://www.arca.fiocruz.br/handle/icict/44797
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Science
publisher.none.fl_str_mv	Science
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/44797/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/44797/2/PatriciaBozza_MartaBosh_etal_IOC_2020.pdf https://www.arca.fiocruz.br/bitstream/icict/44797/3/PatriciaBozza_MartaBosh_etal_IOC_2020.pdf.txt
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense

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