Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/21098 |
Resumo: | grant #USB1-31149-XX-13 (to V. Viswanathan and H. Kornfeld) jointly sponsored by the Indian Department of Biotechnology, the Indian Council of Medical Research and the National Institute for Allergy and Infectious Diseases, National Institutes of Health, and administered by CRDF Global.; FAPESP grant # 2013/08216-2 (to H. Nakaya). H. Nakaya receives a CNPq research fellowship. |
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Medina, Cesar Augusto PradaFukutani, Kiyoshi FerreiraPavan Kumar, NathellaSantana, Leonardo GilBabu, SubashLichtenstein, FlávioWest, KimSivakumar, ShanmugamMenon, Pradeep AViswanathan, VijayAndrade, Bruno de BezerrilNakaya, Helder Tkashi ImotoKornfeld, Hardy2017-09-25T17:09:30Z2017-09-25T17:09:30Z2017MEDINA, C. A. P. et al. Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications. Scientific Reports, v. 7, p. 1999, 2017.2045-2322https://www.arca.fiocruz.br/handle/icict/2109810.1038/s41598-017-01767-4grant #USB1-31149-XX-13 (to V. Viswanathan and H. Kornfeld) jointly sponsored by the Indian Department of Biotechnology, the Indian Council of Medical Research and the National Institute for Allergy and Infectious Diseases, National Institutes of Health, and administered by CRDF Global.; FAPESP grant # 2013/08216-2 (to H. Nakaya). H. Nakaya receives a CNPq research fellowship.University of São Paulo. School of Pharmaceutical Sciences. Department of Pathophysiology and Toxicology. São Paulo, SP, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Imunoparasitologia. Salvador, BA, BrasilNational Institutes of Health- NIRT. International Center for Excellence in Research. Chennai, IndiaFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Instituto Brasileiro para a Investigação da Tuberculose. Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, BrazilNational Institutes of Health- NIRT. International Center for Excellence in Research. Chennai, IndiaUniversity of São Paulo. School of Pharmaceutical Sciences. Department of Pathophysiology and Toxicology. São Paulo, SP, BrazilUniversity of Massachusetts Medical School. Department of Medicine. Worcester, Massachusetts. USANational Institute for Research in Tuberculosis. Chennai, IndiaNational Institute for Research in Tuberculosis. Chennai, IndiaProf. M. Viswanathan Diabetes Research Center. Chennai, IndiaFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Instituto Brasileiro para a Investigação da Tuberculose. Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities. Salvador, BA, Brazil / Vanderbilt University School of Medicine. Division of Infectious Diseases. Department of Medicine Nashville. USAUniversity of São Paulo. School of Pharmaceutical Sciences. Department of Pathophysiology and Toxicology. São Paulo, SP, BrazilUniversity of Massachusetts Medical School. Department of Medicine. Worcester, Massachusetts, USAComorbid diabetes mellitus (DM) increases tuberculosis (TB) risk and adverse outcomes but the pathological interactions between DM and TB remain incompletely understood. We performed an integrative analysis of whole blood gene expression and plasma analytes, comparing South Indian TB patients with and without DM to diabetic and non-diabetic controls without TB. Luminex assay of plasma cytokines and growth factors delineated a distinct biosignature in comorbid TBDM in this cohort. Transcriptional profiling revealed elements in common with published TB signatures from cohorts that excluded DM. Neutrophil count correlated with the molecular degree of perturbation, especially in TBDM patients. Body mass index and HDL cholesterol were negatively correlated with molecular degree of perturbation. Diabetic complication pathways including several pathways linked to epigenetic reprogramming were activated in TBDM above levels observed with DM alone. Our data provide a rationale for trials of host-directed therapies in TBDM, targeting neutrophilic inflammation and diabetic complication pathways to address the greater morbidity and mortality associated with this increasingly prevalent dual burden of communicable and non-communicable diseases.engNature Publishing GroupDiabetes MellitusTuberculoseSaúde públicaDoenças transmissíveisDiabetes MellitusTuberculosisPublic healthcommunicable diseasesSystems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complicationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/21098/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMedina CAP Systems immunology....pdfMedina CAP Systems immunology....pdfapplication/pdf8179492https://www.arca.fiocruz.br/bitstream/icict/21098/2/Medina%20CAP%20Systems%20immunology....pdf2593fd0c71c7a2e54cd7a9a8e0fbb670MD52TEXTMedina CAP Systems immunology....pdf.txtMedina CAP Systems immunology....pdf.txtExtracted texttext/plain69694https://www.arca.fiocruz.br/bitstream/icict/21098/3/Medina%20CAP%20Systems%20immunology....pdf.txta78b3b499738b52524caf5c7612d549eMD53icict/210982023-03-15 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dc.title.pt_BR.fl_str_mv |
Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications |
title |
Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications |
spellingShingle |
Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications Medina, Cesar Augusto Prada Diabetes Mellitus Tuberculose Saúde pública Doenças transmissíveis Diabetes Mellitus Tuberculosis Public health communicable diseases |
title_short |
Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications |
title_full |
Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications |
title_fullStr |
Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications |
title_full_unstemmed |
Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications |
title_sort |
Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications |
author |
Medina, Cesar Augusto Prada |
author_facet |
Medina, Cesar Augusto Prada Fukutani, Kiyoshi Ferreira Pavan Kumar, Nathella Santana, Leonardo Gil Babu, Subash Lichtenstein, Flávio West, Kim Sivakumar, Shanmugam Menon, Pradeep A Viswanathan, Vijay Andrade, Bruno de Bezerril Nakaya, Helder Tkashi Imoto Kornfeld, Hardy |
author_role |
author |
author2 |
Fukutani, Kiyoshi Ferreira Pavan Kumar, Nathella Santana, Leonardo Gil Babu, Subash Lichtenstein, Flávio West, Kim Sivakumar, Shanmugam Menon, Pradeep A Viswanathan, Vijay Andrade, Bruno de Bezerril Nakaya, Helder Tkashi Imoto Kornfeld, Hardy |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Medina, Cesar Augusto Prada Fukutani, Kiyoshi Ferreira Pavan Kumar, Nathella Santana, Leonardo Gil Babu, Subash Lichtenstein, Flávio West, Kim Sivakumar, Shanmugam Menon, Pradeep A Viswanathan, Vijay Andrade, Bruno de Bezerril Nakaya, Helder Tkashi Imoto Kornfeld, Hardy |
dc.subject.other.pt_BR.fl_str_mv |
Diabetes Mellitus Tuberculose Saúde pública Doenças transmissíveis |
topic |
Diabetes Mellitus Tuberculose Saúde pública Doenças transmissíveis Diabetes Mellitus Tuberculosis Public health communicable diseases |
dc.subject.en.pt_BR.fl_str_mv |
Diabetes Mellitus Tuberculosis Public health communicable diseases |
description |
grant #USB1-31149-XX-13 (to V. Viswanathan and H. Kornfeld) jointly sponsored by the Indian Department of Biotechnology, the Indian Council of Medical Research and the National Institute for Allergy and Infectious Diseases, National Institutes of Health, and administered by CRDF Global.; FAPESP grant # 2013/08216-2 (to H. Nakaya). H. Nakaya receives a CNPq research fellowship. |
publishDate |
2017 |
dc.date.accessioned.fl_str_mv |
2017-09-25T17:09:30Z |
dc.date.available.fl_str_mv |
2017-09-25T17:09:30Z |
dc.date.issued.fl_str_mv |
2017 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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dc.identifier.citation.fl_str_mv |
MEDINA, C. A. P. et al. Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications. Scientific Reports, v. 7, p. 1999, 2017. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/21098 |
dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-017-01767-4 |
identifier_str_mv |
MEDINA, C. A. P. et al. Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications. Scientific Reports, v. 7, p. 1999, 2017. 2045-2322 10.1038/s41598-017-01767-4 |
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https://www.arca.fiocruz.br/handle/icict/21098 |
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eng |
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eng |
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Nature Publishing Group |
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Nature Publishing Group |
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