Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus

Detalhes bibliográficos
Autor(a) principal: Alcântara, Luiz Carlos Júnior
Data de Publicação: 2003
Outros Autores: Van Dooren, S., Gonçalves, M. S., Kashima, Simone, Costa, Maria Cristina Ramos, Santos, Fred Luciano Neves, Bittencourt, Achilea Candida Lisboa, Dourado, Maria Inês Costa, Andrade Filho, Antonio, Covas, Dimas Tadeu, Vandamme, Anne Mieke, Castro, Bernardo Galvão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16651
Resumo: Texto completo: acesso restrito. p. 536-542
id UFBA-2_5ef3127ff29ff13a67f21befe3fbd133
oai_identifier_str oai:repositorio.ufba.br:ri/16651
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Alcântara, Luiz Carlos JúniorVan Dooren, S.Gonçalves, M. S.Kashima, SimoneCosta, Maria Cristina RamosSantos, Fred Luciano NevesBittencourt, Achilea Candida LisboaDourado, Maria Inês CostaAndrade Filho, AntonioCovas, Dimas TadeuVandamme, Anne MiekeCastro, Bernardo GalvãoAlcântara, Luiz Carlos JúniorVan Dooren, S.Gonçalves, M. S.Kashima, SimoneCosta, Maria Cristina RamosSantos, Fred Luciano NevesBittencourt, Achilea Candida LisboaDourado, Maria Inês CostaAndrade Filho, AntonioCovas, Dimas TadeuVandamme, Anne MiekeCastro, Bernardo Galvão2014-11-24T15:30:48Z20031525-4135http://repositorio.ufba.br/ri/handle/ri/16651v. 33, n. 4Texto completo: acesso restrito. p. 536-542The city of Salvador, Bahia, Brazil, has sociodemographic characteristics similar to some African cities. Up to now, it has had the highest prevalence of human T-cell lymphotropic virus type I (HTLV-I) infection (1.74%) in the country. To investigate which strains of HTLV-I are circulating in Salvador, we studied isolates from 82 patients infected with HTLV-I: 19 from the general population, 21 from pregnant women, 16 from intravenous drug users, and 26 from patients and their family attending a neurologic clinic. Phylogenetic analysis from part of the LTR fragments showed that most of these isolates belonged to the Transcontinental subgroup of the Cosmopolitan subtype (HTLV-Ia). Only one sample from a pregnant woman was closely related to the Japanese subgroup, suggesting recent introduction of a Japanese HTLV-I lineage into Salvador. βA-Globin haplotypes were examined in 34 infected individuals and found to be atypical, confirming the racial heterogeneity of this population. A total of 20 chromosomes were characterized as Central African Republic (CAR) haplotype (29.4%), 31 (45.6%) were characterized as Benin (BEN) haplotype, and 17 (25%) were characterized as Senegal (SEN) haplotype. Five patients' genotypes (14.7%) were CAR/CAR; 10 (29,4%), BEN/BEN; 9 (26.5%), CAR/BEN; 2 (5.9%), BEN/SEN; and 7 (20.6%), SEN/SEN. One patient's genotype (2.9%) was CAR/SEN. The βA-globin haplotype distribution in Salvador is unusual compared with other Brazilian states. Our data support the hypothesis of multiple post-Columbian introductions of African HTLV-Ia strains in Salvador, Bahia, Brazil.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-12-16T14:25:31Z No. of bitstreams: 1 Alcantara Jr., L.C..pdf: 4754821 bytes, checksum: 3db17ce104d62660d53fa3a93f69e4e1 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-11-24T15:30:48Z (GMT) No. of bitstreams: 1 Alcantara Jr., L.C..pdf: 4754821 bytes, checksum: 3db17ce104d62660d53fa3a93f69e4e1 (MD5)Made available in DSpace on 2014-11-24T15:30:48Z (GMT). No. of bitstreams: 1 Alcantara Jr., L.C..pdf: 4754821 bytes, checksum: 3db17ce104d62660d53fa3a93f69e4e1 (MD5) Previous issue date: 2003β-globin haplotypesBantuHTLV-ILTRSalvador-BrazilSouthern AfricaGlobin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virusJAIDS Journal of Acquired Immune Deficiency Syndromesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAORIGINALAlcantara Jr., L.C..pdfAlcantara Jr., L.C..pdfapplication/pdf4754821https://repositorio.ufba.br/bitstream/ri/16651/1/Alcantara%20Jr.%2c%20L.C..pdf3db17ce104d62660d53fa3a93f69e4e1MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16651/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTAlcantara Jr., L.C..pdf.txtAlcantara Jr., L.C..pdf.txtExtracted texttext/plain7https://repositorio.ufba.br/bitstream/ri/16651/3/Alcantara%20Jr.%2c%20L.C..pdf.txt212b0306580d4f0044d18f9a3edcc832MD53ri/166512022-08-26 11:02:27.694oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-26T14:02:27Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus
dc.title.alternative.pt_BR.fl_str_mv JAIDS Journal of Acquired Immune Deficiency Syndromes
title Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus
spellingShingle Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus
Alcântara, Luiz Carlos Júnior
β-globin haplotypes
Bantu
HTLV-I
LTR
Salvador-Brazil
Southern Africa
title_short Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus
title_full Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus
title_fullStr Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus
title_full_unstemmed Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus
title_sort Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus
author Alcântara, Luiz Carlos Júnior
author_facet Alcântara, Luiz Carlos Júnior
Van Dooren, S.
Gonçalves, M. S.
Kashima, Simone
Costa, Maria Cristina Ramos
Santos, Fred Luciano Neves
Bittencourt, Achilea Candida Lisboa
Dourado, Maria Inês Costa
Andrade Filho, Antonio
Covas, Dimas Tadeu
Vandamme, Anne Mieke
Castro, Bernardo Galvão
author_role author
author2 Van Dooren, S.
Gonçalves, M. S.
Kashima, Simone
Costa, Maria Cristina Ramos
Santos, Fred Luciano Neves
Bittencourt, Achilea Candida Lisboa
Dourado, Maria Inês Costa
Andrade Filho, Antonio
Covas, Dimas Tadeu
Vandamme, Anne Mieke
Castro, Bernardo Galvão
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Alcântara, Luiz Carlos Júnior
Van Dooren, S.
Gonçalves, M. S.
Kashima, Simone
Costa, Maria Cristina Ramos
Santos, Fred Luciano Neves
Bittencourt, Achilea Candida Lisboa
Dourado, Maria Inês Costa
Andrade Filho, Antonio
Covas, Dimas Tadeu
Vandamme, Anne Mieke
Castro, Bernardo Galvão
Alcântara, Luiz Carlos Júnior
Van Dooren, S.
Gonçalves, M. S.
Kashima, Simone
Costa, Maria Cristina Ramos
Santos, Fred Luciano Neves
Bittencourt, Achilea Candida Lisboa
Dourado, Maria Inês Costa
Andrade Filho, Antonio
Covas, Dimas Tadeu
Vandamme, Anne Mieke
Castro, Bernardo Galvão
dc.subject.por.fl_str_mv β-globin haplotypes
Bantu
HTLV-I
LTR
Salvador-Brazil
Southern Africa
topic β-globin haplotypes
Bantu
HTLV-I
LTR
Salvador-Brazil
Southern Africa
description Texto completo: acesso restrito. p. 536-542
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2014-11-24T15:30:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16651
dc.identifier.issn.none.fl_str_mv 1525-4135
dc.identifier.number.pt_BR.fl_str_mv v. 33, n. 4
identifier_str_mv 1525-4135
v. 33, n. 4
url http://repositorio.ufba.br/ri/handle/ri/16651
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/16651/1/Alcantara%20Jr.%2c%20L.C..pdf
https://repositorio.ufba.br/bitstream/ri/16651/2/license.txt
https://repositorio.ufba.br/bitstream/ri/16651/3/Alcantara%20Jr.%2c%20L.C..pdf.txt
bitstream.checksum.fl_str_mv 3db17ce104d62660d53fa3a93f69e4e1
ff6eaa8b858ea317fded99f125f5fcd0
212b0306580d4f0044d18f9a3edcc832
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459467587584000