FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45673 |
Resumo: | Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Laboratório de Virologia e Gastroenterite Infecciosa. Maruipe, Vitória, ES, Brasil. |
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Tonini, Marco André LoureiroBarreira, Débora Maria Pires GonçalvesSantolin, Luciana Bueno de FreitasVolpini, Lays Paula BondiLeite, José Paulo G.Le Moullac-Vaidye, BéatriceLe Pendu, JacquesSpano, Liliana Cruz2021-01-13T19:27:50Z2021-01-13T19:27:50Z2020TONINI, Marco André Loureiro et al. FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil. Viruses, v. 12, p. 1-14, Sept. 2020.1999-4915https://www.arca.fiocruz.br/handle/icict/4567310.3390/v12101084engMDPISuscetibilidade do hospedeiroAntígenos do grupo histo-sangue (HBGAs)NorovírusRotavírusPolimorfismos de FUT2 e FUT3Host susceptibilityHisto-blood group antigens (HBGAs)NorovirusRotavirusSecretor statusPolymorphisms of FUT2 and FUT3LewisFUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Laboratório de Virologia e Gastroenterite Infecciosa. Maruipe, Vitória, ES, Brasil.Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Laboratório de Virologia e Gastroenterite Infecciosa. Maruipe, Vitória, ES, Brasil.Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Laboratório de Virologia e Gastroenterite Infecciosa. Maruipe, Vitória, ES, Brasil.Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Laboratório de Virologia e Gastroenterite Infecciosa. Maruipe, Vitória, ES, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.CRCINA, Inserm, Université de Nantes. France.CRCINA, Inserm, Université de Nantes. France.Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Laboratório de Virologia e Gastroenterite Infecciosa. Maruipe, Vitória, ES, Brasil.Host susceptibility according to human histo-blood group antigens (HBGAs) is widely known for norovirus infection, but is less described for rotavirus. Due to the variable HBGA polymorphism among populations, we aimed to evaluate the association between HBGA phenotypes (ABH, Lewis and secretor status) and susceptibility to rotavirus and norovirus symptomatic infection, and the polymorphisms of FUT2 and FUT3, of children from southeastern Brazil. Paired fecal-buccal specimens from 272 children with acute diarrhea were used to determine rotavirus/norovirus genotypes and HBGAs phenotypes/genotypes, respectively. Altogether, 100 (36.8%) children were infected with rotavirus and norovirus. The rotavirus P[8] genotype predominates (85.7%). Most of the noroviruses (93.8%) belonged to genogroup II (GII). GII.4 Sydney represented 76% (35/46) amongst five other genotypes. Rotavirus and noroviruses infected predominantly children with secretor status (97% and 98.5%, respectively). However, fewer rotavirus-infected children were Lewis-negative (8.6%) than the norovirus-infected ones (18.5%). FUT3 single nucleotide polymorphisms (SNP) occurred mostly at the T59G > G508A > T202C > C314T positions. Our results reinforce the current knowledge that secretors are more susceptible to infection by both rotavirus and norovirus than non-secretors. The high rate for Lewis negative (17.1%) and the combination of SNPs, beyond the secretor status, may reflect the highly mixed population in Brazil.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45673/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJosePauloCLeite_MarcoATonini_etal_IOC_2020.pdfJosePauloCLeite_MarcoATonini_etal_IOC_2020.pdfapplication/pdf329737https://www.arca.fiocruz.br/bitstream/icict/45673/2/JosePauloCLeite_MarcoATonini_etal_IOC_2020.pdf4652e8e53d22943da4201b0730179a05MD52TEXTJosePauloCLeite_MarcoATonini_etal_IOC_2020.pdf.txtJosePauloCLeite_MarcoATonini_etal_IOC_2020.pdf.txtExtracted texttext/plain54696https://www.arca.fiocruz.br/bitstream/icict/45673/3/JosePauloCLeite_MarcoATonini_etal_IOC_2020.pdf.txt605ff431daa7e87327dce53cb33a0fefMD53icict/456732021-03-13 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| dc.title.pt_BR.fl_str_mv |
FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil |
| title |
FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil |
| spellingShingle |
FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil Tonini, Marco André Loureiro Suscetibilidade do hospedeiro Antígenos do grupo histo-sangue (HBGAs) Norovírus Rotavírus Polimorfismos de FUT2 e FUT3 Host susceptibility Histo-blood group antigens (HBGAs) Norovirus Rotavirus Secretor status Polymorphisms of FUT2 and FUT3 Lewis |
| title_short |
FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil |
| title_full |
FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil |
| title_fullStr |
FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil |
| title_full_unstemmed |
FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil |
| title_sort |
FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil |
| author |
Tonini, Marco André Loureiro |
| author_facet |
Tonini, Marco André Loureiro Barreira, Débora Maria Pires Gonçalves Santolin, Luciana Bueno de Freitas Volpini, Lays Paula Bondi Leite, José Paulo G. Le Moullac-Vaidye, Béatrice Le Pendu, Jacques Spano, Liliana Cruz |
| author_role |
author |
| author2 |
Barreira, Débora Maria Pires Gonçalves Santolin, Luciana Bueno de Freitas Volpini, Lays Paula Bondi Leite, José Paulo G. Le Moullac-Vaidye, Béatrice Le Pendu, Jacques Spano, Liliana Cruz |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Tonini, Marco André Loureiro Barreira, Débora Maria Pires Gonçalves Santolin, Luciana Bueno de Freitas Volpini, Lays Paula Bondi Leite, José Paulo G. Le Moullac-Vaidye, Béatrice Le Pendu, Jacques Spano, Liliana Cruz |
| dc.subject.other.pt_BR.fl_str_mv |
Suscetibilidade do hospedeiro Antígenos do grupo histo-sangue (HBGAs) Norovírus Rotavírus Polimorfismos de FUT2 e FUT3 |
| topic |
Suscetibilidade do hospedeiro Antígenos do grupo histo-sangue (HBGAs) Norovírus Rotavírus Polimorfismos de FUT2 e FUT3 Host susceptibility Histo-blood group antigens (HBGAs) Norovirus Rotavirus Secretor status Polymorphisms of FUT2 and FUT3 Lewis |
| dc.subject.en.pt_BR.fl_str_mv |
Host susceptibility Histo-blood group antigens (HBGAs) Norovirus Rotavirus Secretor status Polymorphisms of FUT2 and FUT3 Lewis |
| description |
Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Laboratório de Virologia e Gastroenterite Infecciosa. Maruipe, Vitória, ES, Brasil. |
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2020 |
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2020 |
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2021-01-13T19:27:50Z |
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2021-01-13T19:27:50Z |
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info:eu-repo/semantics/article |
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TONINI, Marco André Loureiro et al. FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil. Viruses, v. 12, p. 1-14, Sept. 2020. |
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https://www.arca.fiocruz.br/handle/icict/45673 |
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1999-4915 |
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10.3390/v12101084 |
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TONINI, Marco André Loureiro et al. FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil. Viruses, v. 12, p. 1-14, Sept. 2020. 1999-4915 10.3390/v12101084 |
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