Lack of association between ABO histo-blood groups, secretor and non-secretor phenotypes, and anti-Toxoplasma gondii antibodies among pregnant women from the northwestern region of São Paulo State, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/225395 |
Resumo: | Introduction: Toxoplasma gondii infects humans in several manners including by the gastrointestinal tract where a-2-L-fucosyltransferase (FUTII) coded by the FUT2 gene (19q13.3) controls the expression of the ABH glycoconjugate profile. The presence of functional FUTII defines the secretor phenotype which is associated with ABO erythrocytic phenotypes. Due to the epidemiological and clinical importance of T. gondii infection, the aim of this work was to test the hypothesis that the ABH glycoconjugate profile expressed in the gastrointestinal tract is associated with the presence of antibodies against this parasite. Material and methods: A total of 367 pregnant women from the High-Risk Pregnancy Clinic of the University Hospital de Base in São José do Rio Preto were enrolled in this study. Two blood samples were drawn with only one being mixed with anticoagulant. ABO erythrocytic phenotyping and detection of anti-T. gondii antibodies were achieved by the haemagglutination test. Identification of the secretor status used the PCR-RFLP method. Results: Differences in the ABO erythrocytic phenotypes (P=0.20) and secretor and nonsecretor phenotypes (P=0.41), either in isolation or in association, were not statistically significant with respect to the presence or absence of anti-T. gondii antibodies. Conclusions: These results suggest that the ABH glycoconjugate profile expressed in the gastrointestinal tract under regulation of the FUT2 gene is not associated with anti-T. gondii antibodies. Copyright © 2008 Termedia & Banach. |
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Lack of association between ABO histo-blood groups, secretor and non-secretor phenotypes, and anti-Toxoplasma gondii antibodies among pregnant women from the northwestern region of São Paulo State, BrazilABO histo-blood groupsFUT2 G428AFUT2 geneSecretor statusToxoplasma gondiiIntroduction: Toxoplasma gondii infects humans in several manners including by the gastrointestinal tract where a-2-L-fucosyltransferase (FUTII) coded by the FUT2 gene (19q13.3) controls the expression of the ABH glycoconjugate profile. The presence of functional FUTII defines the secretor phenotype which is associated with ABO erythrocytic phenotypes. Due to the epidemiological and clinical importance of T. gondii infection, the aim of this work was to test the hypothesis that the ABH glycoconjugate profile expressed in the gastrointestinal tract is associated with the presence of antibodies against this parasite. Material and methods: A total of 367 pregnant women from the High-Risk Pregnancy Clinic of the University Hospital de Base in São José do Rio Preto were enrolled in this study. Two blood samples were drawn with only one being mixed with anticoagulant. ABO erythrocytic phenotyping and detection of anti-T. gondii antibodies were achieved by the haemagglutination test. Identification of the secretor status used the PCR-RFLP method. Results: Differences in the ABO erythrocytic phenotypes (P=0.20) and secretor and nonsecretor phenotypes (P=0.41), either in isolation or in association, were not statistically significant with respect to the presence or absence of anti-T. gondii antibodies. Conclusions: These results suggest that the ABH glycoconjugate profile expressed in the gastrointestinal tract under regulation of the FUT2 gene is not associated with anti-T. gondii antibodies. Copyright © 2008 Termedia & Banach.Biology Department IBILCE São Paulo State University (UNESP), São José do Rio, São Paulo StateImmunogenetics Laboratory Molecular Biology Department Faculty of Medicine of São Jose do Rio Preto (FAMERP), Avenida Brigadeiro Faria Lima, 5416, 15090-000 - São José do RioRegional Blood Bank, São Jose do Rio Preto, São Paulo StateGynaecology and Obstetrics Department Faculty of Medicine of São Jose do Rio Preto (FAMERP), São Jose do Rio Preto, São Paulo StateMicro-organism Investigation Centre Department of Dermatology Infectious and Parasitic Diseases Faculty of Medicine of São Jose do Rio Preto (FAMERP), São Jose do Rio Preto, São Paulo StateBiology Department IBILCE São Paulo State University (UNESP), São José do Rio, São Paulo StateUniversidade Estadual Paulista (UNESP)Faculty of Medicine of São Jose do Rio Preto (FAMERP)Regional Blood BankBrandao de Mattos, Cinara C. [UNESP]Cintra, Juliana R.Ferreira, Ana I.C.Spegiorin, Ligia C.J.F.Galisteu, Katia J.Machado, Ricardo L.D. [UNESP]de Mattos, Luiz Carlos [UNESP]2022-04-28T20:48:15Z2022-04-28T20:48:15Z2008-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article254-258Archives of Medical Science, v. 4, n. 3, p. 254-258, 2008.1734-1922http://hdl.handle.net/11449/2253952-s2.0-58549086792Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArchives of Medical Scienceinfo:eu-repo/semantics/openAccess2022-04-28T20:48:15Zoai:repositorio.unesp.br:11449/225395Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:29:13.199937Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Lack of association between ABO histo-blood groups, secretor and non-secretor phenotypes, and anti-Toxoplasma gondii antibodies among pregnant women from the northwestern region of São Paulo State, Brazil |
title |
Lack of association between ABO histo-blood groups, secretor and non-secretor phenotypes, and anti-Toxoplasma gondii antibodies among pregnant women from the northwestern region of São Paulo State, Brazil |
spellingShingle |
Lack of association between ABO histo-blood groups, secretor and non-secretor phenotypes, and anti-Toxoplasma gondii antibodies among pregnant women from the northwestern region of São Paulo State, Brazil Brandao de Mattos, Cinara C. [UNESP] ABO histo-blood groups FUT2 G428A FUT2 gene Secretor status Toxoplasma gondii |
title_short |
Lack of association between ABO histo-blood groups, secretor and non-secretor phenotypes, and anti-Toxoplasma gondii antibodies among pregnant women from the northwestern region of São Paulo State, Brazil |
title_full |
Lack of association between ABO histo-blood groups, secretor and non-secretor phenotypes, and anti-Toxoplasma gondii antibodies among pregnant women from the northwestern region of São Paulo State, Brazil |
title_fullStr |
Lack of association between ABO histo-blood groups, secretor and non-secretor phenotypes, and anti-Toxoplasma gondii antibodies among pregnant women from the northwestern region of São Paulo State, Brazil |
title_full_unstemmed |
Lack of association between ABO histo-blood groups, secretor and non-secretor phenotypes, and anti-Toxoplasma gondii antibodies among pregnant women from the northwestern region of São Paulo State, Brazil |
title_sort |
Lack of association between ABO histo-blood groups, secretor and non-secretor phenotypes, and anti-Toxoplasma gondii antibodies among pregnant women from the northwestern region of São Paulo State, Brazil |
author |
Brandao de Mattos, Cinara C. [UNESP] |
author_facet |
Brandao de Mattos, Cinara C. [UNESP] Cintra, Juliana R. Ferreira, Ana I.C. Spegiorin, Ligia C.J.F. Galisteu, Katia J. Machado, Ricardo L.D. [UNESP] de Mattos, Luiz Carlos [UNESP] |
author_role |
author |
author2 |
Cintra, Juliana R. Ferreira, Ana I.C. Spegiorin, Ligia C.J.F. Galisteu, Katia J. Machado, Ricardo L.D. [UNESP] de Mattos, Luiz Carlos [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Faculty of Medicine of São Jose do Rio Preto (FAMERP) Regional Blood Bank |
dc.contributor.author.fl_str_mv |
Brandao de Mattos, Cinara C. [UNESP] Cintra, Juliana R. Ferreira, Ana I.C. Spegiorin, Ligia C.J.F. Galisteu, Katia J. Machado, Ricardo L.D. [UNESP] de Mattos, Luiz Carlos [UNESP] |
dc.subject.por.fl_str_mv |
ABO histo-blood groups FUT2 G428A FUT2 gene Secretor status Toxoplasma gondii |
topic |
ABO histo-blood groups FUT2 G428A FUT2 gene Secretor status Toxoplasma gondii |
description |
Introduction: Toxoplasma gondii infects humans in several manners including by the gastrointestinal tract where a-2-L-fucosyltransferase (FUTII) coded by the FUT2 gene (19q13.3) controls the expression of the ABH glycoconjugate profile. The presence of functional FUTII defines the secretor phenotype which is associated with ABO erythrocytic phenotypes. Due to the epidemiological and clinical importance of T. gondii infection, the aim of this work was to test the hypothesis that the ABH glycoconjugate profile expressed in the gastrointestinal tract is associated with the presence of antibodies against this parasite. Material and methods: A total of 367 pregnant women from the High-Risk Pregnancy Clinic of the University Hospital de Base in São José do Rio Preto were enrolled in this study. Two blood samples were drawn with only one being mixed with anticoagulant. ABO erythrocytic phenotyping and detection of anti-T. gondii antibodies were achieved by the haemagglutination test. Identification of the secretor status used the PCR-RFLP method. Results: Differences in the ABO erythrocytic phenotypes (P=0.20) and secretor and nonsecretor phenotypes (P=0.41), either in isolation or in association, were not statistically significant with respect to the presence or absence of anti-T. gondii antibodies. Conclusions: These results suggest that the ABH glycoconjugate profile expressed in the gastrointestinal tract under regulation of the FUT2 gene is not associated with anti-T. gondii antibodies. Copyright © 2008 Termedia & Banach. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-12-01 2022-04-28T20:48:15Z 2022-04-28T20:48:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Archives of Medical Science, v. 4, n. 3, p. 254-258, 2008. 1734-1922 http://hdl.handle.net/11449/225395 2-s2.0-58549086792 |
identifier_str_mv |
Archives of Medical Science, v. 4, n. 3, p. 254-258, 2008. 1734-1922 2-s2.0-58549086792 |
url |
http://hdl.handle.net/11449/225395 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Archives of Medical Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
254-258 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128366725824512 |