MLST-based population genetic analysis in a global context reveals clonality amongst Cryptococcus neoformans var. grubii VNI isolates from HIV patients in Southeastern Brazil

Detalhes bibliográficos
Autor(a) principal: Ferreira-Paim, Kennio
Data de Publicação: 2017
Outros Autores: Andrade-Silva, Leonardo, Fonseca, Fernanda M., Ferreira, Thatiana B., Mora, Delio J., Andrade-Silva, Juliana, Khan, Aziza, Dao, Aiken, Reis, Eduardo C., Almeida, Margarete T. G., Maltos, Andre, Junior, Virmondes R., Trilles, Luciana, Rickerts, Volker, Chindamporn, Ariya, Sykes, Jane E., Cogliati, Massimo, Nielsen, Kirsten, Boekhout, Teun, Fisher, Matthew, Kwon-Chung, June, Engelthaler, David M., Lazéra, Marcia, Meyer, Wieland, Silva-Vergara, Mario L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34296
Resumo: University of Sydney. Marie Bashir Institute for Emerging Infectious Diseases and Biosecurity. Sydney, Australia. / University of Sydney. Sydney Medical School-Westmead Hospital, Sydney, Australia / The Westmead Institute for Medical Research. Sydney, Australia / Triangulo Mineiro Federal University. Infectious Disease Department. Uberaba, MG, Brazil.
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spelling Ferreira-Paim, KennioAndrade-Silva, LeonardoFonseca, Fernanda M.Ferreira, Thatiana B.Mora, Delio J.Andrade-Silva, JulianaKhan, AzizaDao, AikenReis, Eduardo C.Almeida, Margarete T. G.Maltos, AndreJunior, Virmondes R.Trilles, LucianaRickerts, VolkerChindamporn, AriyaSykes, Jane E.Cogliati, MassimoNielsen, KirstenBoekhout, TeunFisher, MatthewKwon-Chung, JuneEngelthaler, David M.Lazéra, MarciaMeyer, WielandSilva-Vergara, Mario L.2019-07-19T15:32:58Z2019-07-19T15:32:58Z2017FERREIRA-PAIM, Kennio et al. MLST-based population genetic analysis in a global context reveals clonality amongst Cryptococcus neoformans var. grubii VNI isolates from HIV patients in southeastern Brazil. Plos Neglected Tropical Diseases, p. 1-29, Jan. 2017.1935-2727https://www.arca.fiocruz.br/handle/icict/3429610.1371/journal.pntd.00052231935-2735engPublic Library of ScienceMLST-based population genetic analysis in a global context reveals clonality amongst Cryptococcus neoformans var. grubii VNI isolates from HIV patients in Southeastern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Sydney. Marie Bashir Institute for Emerging Infectious Diseases and Biosecurity. Sydney, Australia. / University of Sydney. Sydney Medical School-Westmead Hospital, Sydney, Australia / The Westmead Institute for Medical Research. Sydney, Australia / Triangulo Mineiro Federal University. Infectious Disease Department. Uberaba, MG, Brazil.Triangulo Mineiro Federal University. Infectious Disease Department. Uberaba, MG, Brazil.Federal University of Piauí. Biomedicine Department. Parnaíba, PI, Brazil.Triangulo Mineiro Federal University. Infectious Disease Department. Uberaba, MG, Brazil.Triangulo Mineiro Federal University. Infectious Disease Department. Uberaba, MG, Brazil.Triangulo Mineiro Federal University. Infectious Disease Department. Uberaba, MG, Brazil.University of Sydney. Marie Bashir Institute for Emerging Infectious Diseases and Biosecurity. Sydney, Australia. / University of Sydney. Sydney Medical School-Westmead Hospital, Sydney, Australia / The Westmead Institute for Medical Research. Sydney, Australia.University of Sydney. Marie Bashir Institute for Emerging Infectious Diseases and Biosecurity. Sydney, Australia. / University of Sydney. Sydney Medical School-Westmead Hospital, Sydney, Australia / The Westmead Institute for Medical Research. Sydney, Australia.Faculty of Medicine of São José do Rio Preto. Infectious Disease Department. São José do Rio Preto, SP, Brazil.Faculty of Medicine of São José do Rio Preto. Infectious Disease Department. São José do Rio Preto, SP, Brazil.Triangulo Mineiro Federal University. Infectious Disease Department. Uberaba, MG, Brazil.Triangulo Mineiro Federal University. Infectious Disease Department. Uberaba, MG, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Robert Koch Institute. Mycology Section. Berlin, Germany.Chulalongkorn University. Faculty of Medicine. Department of Microbiology. Mycology Unit. Bangkok, Thailand.University of California. Department of Medicine and Epidemiology. Davis, CA, USA.Università degli Studi di Milano. Dip. Scienze Biomediche per la Salute. Laboratorio Micologia Medica. Milano, Italy.University of Minnesota. Medical School. Department of Microbiology and Immunology. Minneapolis, MS, USA.CBS-KNAW Fungal Biodiversity Centre. Department of Yeast and Basidiomycete Research. Utrecht, The Netherlands.Imperial College London. Department of Infectious Disease Epidemiology. London, UK.National Institute of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Clinical Infectious Diseases. Molecular Microbiology Section. Bethesda, MD, USA.Translational Genomics Research Institute. Flagstaff, AZ, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.University of Sydney. Marie Bashir Institute for Emerging Infectious Diseases and Biosecurity. Sydney, Australia. / University of Sydney. Sydney Medical School-Westmead Hospital, Sydney, Australia / The Westmead Institute for Medical Research. Sydney, Australia.Triangulo Mineiro Federal University. Infectious Disease Department. Uberaba, MG, Brazil.Cryptococcosis is an important fungal infection in immunocompromised individuals, especially those infected with HIV. In Brazil, despite the free availability of antiretroviral therapy (ART) in the public health system, the mortality rate due to Cryptococcus neoformans meningitis is still high. To obtain a more detailed picture of the population genetic structure of this species in southeast Brazil, we studied 108 clinical isolates from 101 patients and 35 environmental isolates. Among the patients, 59% had a fatal outcome mainly in HIV-positive male patients. All the isolates were found to be C. neoformans var. grubii major molecular type VNI and mating type locus alpha. Twelve were identified as diploid by flow cytometry, being homozygous (AαAα) for the mating type and by PCR screening of the STE20, GPA1, and PAK1 genes. Using the ISHAM consensus multilocus sequence typing (MLST) scheme, 13 sequence types (ST) were identified, with one being newly described. ST93 was identified from 81 (75%) of the clinical isolates, while ST77 and ST93 were identified from 19 (54%) and 10 (29%) environmental isolates, respectively. The southeastern Brazilian isolates had an overwhelming clonal population structure. When compared with populations from different continents based on data extracted from the ISHAM-MLST database (mlst.mycologylab.org) they showed less genetic variability. Two main clusters within C. neoformans var. grubii VNI were identified that diverged from VNB around 0.58 to 4.8 million years ago.Cryptococcus neoformans var. grubiiVNIHIV PatientsSoutheastern Brazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/34296/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Ferreira-Paim_Kennio_etal_INI_2017.pdfve_Ferreira-Paim_Kennio_etal_INI_2017.pdfapplication/pdf2872764https://www.arca.fiocruz.br/bitstream/icict/34296/2/ve_Ferreira-Paim_Kennio_etal_INI_2017.pdf5175c3e3da587969012129cb6d8cf4eeMD52TEXTve_Ferreira-Paim_Kennio_etal_INI_2017.pdf.txtve_Ferreira-Paim_Kennio_etal_INI_2017.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv MLST-based population genetic analysis in a global context reveals clonality amongst Cryptococcus neoformans var. grubii VNI isolates from HIV patients in Southeastern Brazil
title MLST-based population genetic analysis in a global context reveals clonality amongst Cryptococcus neoformans var. grubii VNI isolates from HIV patients in Southeastern Brazil
spellingShingle MLST-based population genetic analysis in a global context reveals clonality amongst Cryptococcus neoformans var. grubii VNI isolates from HIV patients in Southeastern Brazil
Ferreira-Paim, Kennio
Cryptococcus neoformans var. grubii
VNI
HIV Patients
Southeastern Brazil
title_short MLST-based population genetic analysis in a global context reveals clonality amongst Cryptococcus neoformans var. grubii VNI isolates from HIV patients in Southeastern Brazil
title_full MLST-based population genetic analysis in a global context reveals clonality amongst Cryptococcus neoformans var. grubii VNI isolates from HIV patients in Southeastern Brazil
title_fullStr MLST-based population genetic analysis in a global context reveals clonality amongst Cryptococcus neoformans var. grubii VNI isolates from HIV patients in Southeastern Brazil
title_full_unstemmed MLST-based population genetic analysis in a global context reveals clonality amongst Cryptococcus neoformans var. grubii VNI isolates from HIV patients in Southeastern Brazil
title_sort MLST-based population genetic analysis in a global context reveals clonality amongst Cryptococcus neoformans var. grubii VNI isolates from HIV patients in Southeastern Brazil
author Ferreira-Paim, Kennio
author_facet Ferreira-Paim, Kennio
Andrade-Silva, Leonardo
Fonseca, Fernanda M.
Ferreira, Thatiana B.
Mora, Delio J.
Andrade-Silva, Juliana
Khan, Aziza
Dao, Aiken
Reis, Eduardo C.
Almeida, Margarete T. G.
Maltos, Andre
Junior, Virmondes R.
Trilles, Luciana
Rickerts, Volker
Chindamporn, Ariya
Sykes, Jane E.
Cogliati, Massimo
Nielsen, Kirsten
Boekhout, Teun
Fisher, Matthew
Kwon-Chung, June
Engelthaler, David M.
Lazéra, Marcia
Meyer, Wieland
Silva-Vergara, Mario L.
author_role author
author2 Andrade-Silva, Leonardo
Fonseca, Fernanda M.
Ferreira, Thatiana B.
Mora, Delio J.
Andrade-Silva, Juliana
Khan, Aziza
Dao, Aiken
Reis, Eduardo C.
Almeida, Margarete T. G.
Maltos, Andre
Junior, Virmondes R.
Trilles, Luciana
Rickerts, Volker
Chindamporn, Ariya
Sykes, Jane E.
Cogliati, Massimo
Nielsen, Kirsten
Boekhout, Teun
Fisher, Matthew
Kwon-Chung, June
Engelthaler, David M.
Lazéra, Marcia
Meyer, Wieland
Silva-Vergara, Mario L.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira-Paim, Kennio
Andrade-Silva, Leonardo
Fonseca, Fernanda M.
Ferreira, Thatiana B.
Mora, Delio J.
Andrade-Silva, Juliana
Khan, Aziza
Dao, Aiken
Reis, Eduardo C.
Almeida, Margarete T. G.
Maltos, Andre
Junior, Virmondes R.
Trilles, Luciana
Rickerts, Volker
Chindamporn, Ariya
Sykes, Jane E.
Cogliati, Massimo
Nielsen, Kirsten
Boekhout, Teun
Fisher, Matthew
Kwon-Chung, June
Engelthaler, David M.
Lazéra, Marcia
Meyer, Wieland
Silva-Vergara, Mario L.
dc.subject.en.pt_BR.fl_str_mv Cryptococcus neoformans var. grubii
VNI
HIV Patients
Southeastern Brazil
topic Cryptococcus neoformans var. grubii
VNI
HIV Patients
Southeastern Brazil
description University of Sydney. Marie Bashir Institute for Emerging Infectious Diseases and Biosecurity. Sydney, Australia. / University of Sydney. Sydney Medical School-Westmead Hospital, Sydney, Australia / The Westmead Institute for Medical Research. Sydney, Australia / Triangulo Mineiro Federal University. Infectious Disease Department. Uberaba, MG, Brazil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2019-07-19T15:32:58Z
dc.date.available.fl_str_mv 2019-07-19T15:32:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERREIRA-PAIM, Kennio et al. MLST-based population genetic analysis in a global context reveals clonality amongst Cryptococcus neoformans var. grubii VNI isolates from HIV patients in southeastern Brazil. Plos Neglected Tropical Diseases, p. 1-29, Jan. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34296
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0005223
dc.identifier.eissn.none.fl_str_mv 1935-2735
identifier_str_mv FERREIRA-PAIM, Kennio et al. MLST-based population genetic analysis in a global context reveals clonality amongst Cryptococcus neoformans var. grubii VNI isolates from HIV patients in southeastern Brazil. Plos Neglected Tropical Diseases, p. 1-29, Jan. 2017.
1935-2727
10.1371/journal.pntd.0005223
1935-2735
url https://www.arca.fiocruz.br/handle/icict/34296
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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