Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil

Detalhes bibliográficos
Autor(a) principal: Bottecchia, Marcelle
Data de Publicação: 2008
Outros Autores: Souto, Francisco J. D., O, Kycia M. R., Amendola, Marcia, Brandão, Carlos E., Niel, Christian, Gomes, Selma A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27796
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.
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spelling Bottecchia, MarcelleSouto, Francisco J. D.O, Kycia M. R.Amendola, MarciaBrandão, Carlos E.Niel, ChristianGomes, Selma A.2018-08-02T14:57:58Z2018-08-02T14:57:58Z2008BOTTECCHIA, Marcelle; et al. Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil. BMC Microbiology, v. 8, n.11, 10p, Jan. 2008.1471-2180https://www.arca.fiocruz.br/handle/icict/2779610.1186/1471-2180-8-11engBioMed CentralGenótipos do vírus da Hepatite BMutaçõesResistência a medicamentosTerapia com LamivudinaBrasilHepatitis B virus genotypesresistance mutationslamivudine therapyBrazilHepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.Universidade Federal de Mato Grosso. Faculdade de Ciências Médicas. Núcleo de Estudos de Doenças Infecciosas e Tropicais. Cuiabá, MT, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil / Fundação Municipal de Saúde de Petrópolis. Hospital Alcides Carneiro. Petrópolis, RJ. Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.Lamivudine is an oral nucleoside analogue widely used for the treatment of chronic hepatitis B. The main limitation of lamivudine use is the selection of resistant mutations that increases with time of utilization. Hepatitis B virus (HBV) isolates have been classified into eight genotypes (A to H) with distinct geographical distributions. HBV genotypes may also influence pathogenic properties and therapeutic features. Here, we analyzed the HBV genotype distribution and the nature and frequency of lamivudine resistant mutations among 36 patients submitted to lamivudine treatment for 12 to 84 months.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27796/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALkiciamro_etal_IOC_2008.pdfkiciamro_etal_IOC_2008.pdfapplication/pdf506267https://www.arca.fiocruz.br/bitstream/icict/27796/2/kiciamro_etal_IOC_2008.pdff7829a89c2411e97f96c3d5a4123f436MD52TEXTkiciamro_etal_IOC_2008.pdf.txtkiciamro_etal_IOC_2008.pdf.txtExtracted texttext/plain45600https://www.arca.fiocruz.br/bitstream/icict/27796/3/kiciamro_etal_IOC_2008.pdf.txt0474cec9f2d97e168f8e28b32aae93f2MD53icict/277962018-08-15 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dc.title.pt_BR.fl_str_mv Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil
title Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil
spellingShingle Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil
Bottecchia, Marcelle
Genótipos do vírus da Hepatite B
Mutações
Resistência a medicamentos
Terapia com Lamivudina
Brasil
Hepatitis B virus genotypes
resistance mutations
lamivudine therapy
Brazil
title_short Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil
title_full Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil
title_fullStr Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil
title_full_unstemmed Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil
title_sort Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil
author Bottecchia, Marcelle
author_facet Bottecchia, Marcelle
Souto, Francisco J. D.
O, Kycia M. R.
Amendola, Marcia
Brandão, Carlos E.
Niel, Christian
Gomes, Selma A.
author_role author
author2 Souto, Francisco J. D.
O, Kycia M. R.
Amendola, Marcia
Brandão, Carlos E.
Niel, Christian
Gomes, Selma A.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bottecchia, Marcelle
Souto, Francisco J. D.
O, Kycia M. R.
Amendola, Marcia
Brandão, Carlos E.
Niel, Christian
Gomes, Selma A.
dc.subject.other.pt_BR.fl_str_mv Genótipos do vírus da Hepatite B
Mutações
Resistência a medicamentos
Terapia com Lamivudina
Brasil
topic Genótipos do vírus da Hepatite B
Mutações
Resistência a medicamentos
Terapia com Lamivudina
Brasil
Hepatitis B virus genotypes
resistance mutations
lamivudine therapy
Brazil
dc.subject.en.pt_BR.fl_str_mv Hepatitis B virus genotypes
resistance mutations
lamivudine therapy
Brazil
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2018-08-02T14:57:58Z
dc.date.available.fl_str_mv 2018-08-02T14:57:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BOTTECCHIA, Marcelle; et al. Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil. BMC Microbiology, v. 8, n.11, 10p, Jan. 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27796
dc.identifier.issn.pt_BR.fl_str_mv 1471-2180
dc.identifier.doi.none.fl_str_mv 10.1186/1471-2180-8-11
identifier_str_mv BOTTECCHIA, Marcelle; et al. Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil. BMC Microbiology, v. 8, n.11, 10p, Jan. 2008.
1471-2180
10.1186/1471-2180-8-11
url https://www.arca.fiocruz.br/handle/icict/27796
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/27796/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/27796/2/kiciamro_etal_IOC_2008.pdf
https://www.arca.fiocruz.br/bitstream/icict/27796/3/kiciamro_etal_IOC_2008.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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