Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies

Detalhes bibliográficos
Autor(a) principal: Soeiro, Maria de Nazaré C.
Data de Publicação: 2011
Outros Autores: Castro, Solange Lisboa de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15955
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
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spelling Soeiro, Maria de Nazaré C.Castro, Solange Lisboa de2016-09-27T11:29:40Z2016-09-27T11:29:40Z2011SOEIRO, Maria de Nazaré C.; CASTRO, Solange Lisboa de. Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies. Open Medicinal Chemistry Journal, v. 5, p. 21-30, 2011.1874-1045https://www.arca.fiocruz.br/handle/icict/1595510.2174/1874104501105010021engBentham OpenTrypanosoma cruziDoença de ChagasQuimioterapia experimentalNaftoquinonasDiamidinas aromáticosDerivados megazolTrypanosoma cruziexperimental chemotherapyaromatic diamidinesnaphthoquinonesmegazol derivativesChagas DiseaseScreening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Chagas disease (CD), caused by the intracellular protozoan Trypanosoma cruzi, is a parasitic illness endemic in Latin America. In the centennial after CD discovery by Carlos Chagas (1909), although it still represents an important public health problem in these affected areas, the existing chemotherapy, based on benznidazole and nifurtimox (both introduced more than four decades ago), is far from being considered ideal due to substantial toxicity, variable effect on different parasite stocks and well-known poor activity on the chronic phase. CD is considered one of the major “neglected” diseases of the world, as commercial incentives are very limited to guarantee investments for developing and discovering novel drugs. In this context, our group has been pursuing, over the last years, the efficacy, selectivity, toxicity, cellular targets and mechanisms of action of new potential anti-T. cruzi candidates screened from an in-house compound library of different research groups in the area of medicinal chemistry. A brief review regarding these studies will be discussed, mainly related to the effect on T. cruzi of (i) diamidines and related compounds, (ii) natural naphthoquinone derivatives, and (iii) megazol derivatives.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15955/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmarianazare_soeiro_etal_IOC_2011.pdfmarianazare_soeiro_etal_IOC_2011.pdfapplication/pdf317127https://www.arca.fiocruz.br/bitstream/icict/15955/2/marianazare_soeiro_etal_IOC_2011.pdff509b68f268018e945983c66a79f84e3MD52TEXTmarianazare_soeiro_etal_IOC_2011.pdf.txtmarianazare_soeiro_etal_IOC_2011.pdf.txtExtracted texttext/plain65714https://www.arca.fiocruz.br/bitstream/icict/15955/3/marianazare_soeiro_etal_IOC_2011.pdf.txtf7635aa9aae6b55e53044b242c9ad5c6MD53icict/159552019-06-01 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dc.title.pt_BR.fl_str_mv Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies
title Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies
spellingShingle Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies
Soeiro, Maria de Nazaré C.
Trypanosoma cruzi
Doença de Chagas
Quimioterapia experimental
Naftoquinonas
Diamidinas aromáticos
Derivados megazol
Trypanosoma cruzi
experimental chemotherapy
aromatic diamidines
naphthoquinones
megazol derivatives
Chagas Disease
title_short Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies
title_full Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies
title_fullStr Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies
title_full_unstemmed Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies
title_sort Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies
author Soeiro, Maria de Nazaré C.
author_facet Soeiro, Maria de Nazaré C.
Castro, Solange Lisboa de
author_role author
author2 Castro, Solange Lisboa de
author2_role author
dc.contributor.author.fl_str_mv Soeiro, Maria de Nazaré C.
Castro, Solange Lisboa de
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Doença de Chagas
Quimioterapia experimental
Naftoquinonas
Diamidinas aromáticos
Derivados megazol
topic Trypanosoma cruzi
Doença de Chagas
Quimioterapia experimental
Naftoquinonas
Diamidinas aromáticos
Derivados megazol
Trypanosoma cruzi
experimental chemotherapy
aromatic diamidines
naphthoquinones
megazol derivatives
Chagas Disease
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
experimental chemotherapy
aromatic diamidines
naphthoquinones
megazol derivatives
Chagas Disease
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2016-09-27T11:29:40Z
dc.date.available.fl_str_mv 2016-09-27T11:29:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOEIRO, Maria de Nazaré C.; CASTRO, Solange Lisboa de. Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies. Open Medicinal Chemistry Journal, v. 5, p. 21-30, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15955
dc.identifier.issn.pt_BR.fl_str_mv 1874-1045
dc.identifier.doi.pt_BR.fl_str_mv 10.2174/1874104501105010021
identifier_str_mv SOEIRO, Maria de Nazaré C.; CASTRO, Solange Lisboa de. Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies. Open Medicinal Chemistry Journal, v. 5, p. 21-30, 2011.
1874-1045
10.2174/1874104501105010021
url https://www.arca.fiocruz.br/handle/icict/15955
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Bentham Open
publisher.none.fl_str_mv Bentham Open
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/15955/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/15955/2/marianazare_soeiro_etal_IOC_2011.pdf
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