Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/17939 |
Resumo: | Instituto Gonçalo Moniz/Fundação Oswaldo Cruz (IGM/FIOCRUZ); Coordenação de Aperfeiçoamento do Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa |
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Veras, Patrícia Sampaio TavaresMenezes, Juliana Perrone Bezerra de2017-03-06T16:41:42Z2017-03-06T16:41:42Z2016VERAS, P. S. T.; MENEZES, J. P. B. Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection. International Journal of Molecular Sciences, v. 17, p. 1270, 2016.1661-6596https://www.arca.fiocruz.br/handle/icict/1793910.3390/ijms17081270Instituto Gonçalo Moniz/Fundação Oswaldo Cruz (IGM/FIOCRUZ); Coordenação de Aperfeiçoamento do Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à PesquisaFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, BrasilInstituto Nacional de Ciência e Tecnologia para Doenças Tropicais. INCT-DT. Salvador, BA, BrasilLeishmania is a protozoan parasite that causes a wide range of different clinical manifestations in mammalian hosts. It is a major public health risk on different continents and represents one of the most important neglected diseases. Due to the high toxicity of the drugs currently used, and in the light of increasing drug resistance, there is a critical need to develop new drugs and vaccines to control Leishmania infection. Over the past few years, proteomics has become an important tool to understand the underlying biology of Leishmania parasites and host interaction. The large-scale study of proteins, both in parasites and within the host in response to infection, can accelerate the discovery of new therapeutic targets. By studying the proteomes of host cells and tissues infected with Leishmania, as well as changes in protein profiles among promastigotes and amastigotes, scientists hope to better understand the biology involved in the parasite survival and the host-parasite interaction. This review demonstrates the feasibility of proteomics as an approach to identify new proteins involved in Leishmania differentiation and intracellular survival.engMDPIProteômicaLeishmaniaSobrevivência intracelularProteomicsLeishmaniaIntracellular survivalUsing Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17939/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVeras PST Using proteomics....pdfVeras PST Using proteomics....pdfapplication/pdf2023439https://www.arca.fiocruz.br/bitstream/icict/17939/2/Veras%20PST%20Using%20proteomics....pdf69c96bf28d97a98ea5b1656099c81ac8MD52TEXTVeras PST Using proteomics....pdf.txtVeras PST 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dc.title.pt_BR.fl_str_mv |
Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection |
title |
Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection |
spellingShingle |
Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection Veras, Patrícia Sampaio Tavares Proteômica Leishmania Sobrevivência intracelular Proteomics Leishmania Intracellular survival |
title_short |
Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection |
title_full |
Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection |
title_fullStr |
Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection |
title_full_unstemmed |
Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection |
title_sort |
Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection |
author |
Veras, Patrícia Sampaio Tavares |
author_facet |
Veras, Patrícia Sampaio Tavares Menezes, Juliana Perrone Bezerra de |
author_role |
author |
author2 |
Menezes, Juliana Perrone Bezerra de |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Veras, Patrícia Sampaio Tavares Menezes, Juliana Perrone Bezerra de |
dc.subject.other.pt_BR.fl_str_mv |
Proteômica Leishmania Sobrevivência intracelular |
topic |
Proteômica Leishmania Sobrevivência intracelular Proteomics Leishmania Intracellular survival |
dc.subject.en.pt_BR.fl_str_mv |
Proteomics Leishmania Intracellular survival |
description |
Instituto Gonçalo Moniz/Fundação Oswaldo Cruz (IGM/FIOCRUZ); Coordenação de Aperfeiçoamento do Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-03-06T16:41:42Z |
dc.date.available.fl_str_mv |
2017-03-06T16:41:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
VERAS, P. S. T.; MENEZES, J. P. B. Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection. International Journal of Molecular Sciences, v. 17, p. 1270, 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/17939 |
dc.identifier.issn.pt_BR.fl_str_mv |
1661-6596 |
dc.identifier.doi.none.fl_str_mv |
10.3390/ijms17081270 |
identifier_str_mv |
VERAS, P. S. T.; MENEZES, J. P. B. Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection. International Journal of Molecular Sciences, v. 17, p. 1270, 2016. 1661-6596 10.3390/ijms17081270 |
url |
https://www.arca.fiocruz.br/handle/icict/17939 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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