Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection

Detalhes bibliográficos
Autor(a) principal: Veras, Patrícia Sampaio Tavares
Data de Publicação: 2016
Outros Autores: Menezes, Juliana Perrone Bezerra de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/17939
Resumo: Instituto Gonçalo Moniz/Fundação Oswaldo Cruz (IGM/FIOCRUZ); Coordenação de Aperfeiçoamento do Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa
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spelling Veras, Patrícia Sampaio TavaresMenezes, Juliana Perrone Bezerra de2017-03-06T16:41:42Z2017-03-06T16:41:42Z2016VERAS, P. S. T.; MENEZES, J. P. B. Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection. International Journal of Molecular Sciences, v. 17, p. 1270, 2016.1661-6596https://www.arca.fiocruz.br/handle/icict/1793910.3390/ijms17081270Instituto Gonçalo Moniz/Fundação Oswaldo Cruz (IGM/FIOCRUZ); Coordenação de Aperfeiçoamento do Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à PesquisaFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, BrasilInstituto Nacional de Ciência e Tecnologia para Doenças Tropicais. INCT-DT. Salvador, BA, BrasilLeishmania is a protozoan parasite that causes a wide range of different clinical manifestations in mammalian hosts. It is a major public health risk on different continents and represents one of the most important neglected diseases. Due to the high toxicity of the drugs currently used, and in the light of increasing drug resistance, there is a critical need to develop new drugs and vaccines to control Leishmania infection. Over the past few years, proteomics has become an important tool to understand the underlying biology of Leishmania parasites and host interaction. The large-scale study of proteins, both in parasites and within the host in response to infection, can accelerate the discovery of new therapeutic targets. By studying the proteomes of host cells and tissues infected with Leishmania, as well as changes in protein profiles among promastigotes and amastigotes, scientists hope to better understand the biology involved in the parasite survival and the host-parasite interaction. This review demonstrates the feasibility of proteomics as an approach to identify new proteins involved in Leishmania differentiation and intracellular survival.engMDPIProteômicaLeishmaniaSobrevivência intracelularProteomicsLeishmaniaIntracellular survivalUsing Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17939/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVeras PST Using proteomics....pdfVeras PST Using proteomics....pdfapplication/pdf2023439https://www.arca.fiocruz.br/bitstream/icict/17939/2/Veras%20PST%20Using%20proteomics....pdf69c96bf28d97a98ea5b1656099c81ac8MD52TEXTVeras PST Using proteomics....pdf.txtVeras PST 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dc.title.pt_BR.fl_str_mv Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection
title Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection
spellingShingle Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection
Veras, Patrícia Sampaio Tavares
Proteômica
Leishmania
Sobrevivência intracelular
Proteomics
Leishmania
Intracellular survival
title_short Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection
title_full Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection
title_fullStr Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection
title_full_unstemmed Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection
title_sort Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection
author Veras, Patrícia Sampaio Tavares
author_facet Veras, Patrícia Sampaio Tavares
Menezes, Juliana Perrone Bezerra de
author_role author
author2 Menezes, Juliana Perrone Bezerra de
author2_role author
dc.contributor.author.fl_str_mv Veras, Patrícia Sampaio Tavares
Menezes, Juliana Perrone Bezerra de
dc.subject.other.pt_BR.fl_str_mv Proteômica
Leishmania
Sobrevivência intracelular
topic Proteômica
Leishmania
Sobrevivência intracelular
Proteomics
Leishmania
Intracellular survival
dc.subject.en.pt_BR.fl_str_mv Proteomics
Leishmania
Intracellular survival
description Instituto Gonçalo Moniz/Fundação Oswaldo Cruz (IGM/FIOCRUZ); Coordenação de Aperfeiçoamento do Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-03-06T16:41:42Z
dc.date.available.fl_str_mv 2017-03-06T16:41:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VERAS, P. S. T.; MENEZES, J. P. B. Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection. International Journal of Molecular Sciences, v. 17, p. 1270, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/17939
dc.identifier.issn.pt_BR.fl_str_mv 1661-6596
dc.identifier.doi.none.fl_str_mv 10.3390/ijms17081270
identifier_str_mv VERAS, P. S. T.; MENEZES, J. P. B. Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection. International Journal of Molecular Sciences, v. 17, p. 1270, 2016.
1661-6596
10.3390/ijms17081270
url https://www.arca.fiocruz.br/handle/icict/17939
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/17939/1/license.txt
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