Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1998 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36986 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. |
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Lenzi, Henrique L.Kimmel, EitanSchechtman, HelioMachado, Marcelo PelajoRomanha, Waldemiro S.Pacheco, Ronaldo G.Mariano, MarioLenzi, Jane A.2019-11-12T10:44:15Z2019-11-12T10:44:15Z1998LENZI, Henrique L. et al. Histoarchitecture of Schistosomal Granuloma Development and Involution: Morphogenetic and Biomechanical Approaches. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 93, Suppl. 1, p. 141-151, 1998.0074-0276https://www.arca.fiocruz.br/handle/icict/3698610.1590/s0074-027619980007000201678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Schistosoma mansoniGranulomaBiomecânicaFibroseMatriz extracelularMicroscopia confocal a laserSchistosoma mansoniGranulomaBiomechanicsFibrosisExtracellular matrixLaser confocal microscopyHistoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approachesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Technion-Israel Institute of Technology. Department of Agricultural Engineering. Technion City, Haifa, Israel.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Departamento de Medicina Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Departamento de Medicina Geral. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. São Paulo, SP, Brasil.Sem afiliação.The authors present morphogenetic and biomechanical approaches on the concept of the Schistosoma mansoni granulomas, considering them as organoid structures that depend on cellular adhesion and sorting, forming rearrangement into hierarchical concentric layers, creating tension-dependent structures, aiming to acquire round form, since this is the minimal energy form, in which opposing forces pull in equally from all directions and are in balance. From the morphogenetic point of view, the granulomas function as little organs, presenting maturative and involutional stages in their development with final disappearance (pre-granulomatous stages, subdivided in: weakly and/or initial reactive and exudative; granulomatous stages: exudative-productive, productive and involutional). A model for the development of granulomas was suggested, according to the following stages: encapsulating, focal histolysis, fiber production, orientation and compacting and involution and disintegration. The authors concluded that schistosomal granuloma is not a tangled web of individual cells and fibers, but an organized structure composed by host and parasite components, which is not formed to attack the miracidia, but functions as an hybrid interface between two different phylogenetic beings.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36986/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarceloPMachado_etal_IOC_1998.pdfMarceloPMachado_etal_IOC_1998.pdfapplication/pdf778173https://www.arca.fiocruz.br/bitstream/icict/36986/2/MarceloPMachado_etal_IOC_1998.pdf58eb48201b64559cea853e6d2a55075bMD52TEXTMarceloPMachado_etal_IOC_1998.pdf.txtMarceloPMachado_etal_IOC_1998.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches |
| title |
Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches |
| spellingShingle |
Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches Lenzi, Henrique L. Schistosoma mansoni Granuloma Biomecânica Fibrose Matriz extracelular Microscopia confocal a laser Schistosoma mansoni Granuloma Biomechanics Fibrosis Extracellular matrix Laser confocal microscopy |
| title_short |
Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches |
| title_full |
Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches |
| title_fullStr |
Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches |
| title_full_unstemmed |
Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches |
| title_sort |
Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches |
| author |
Lenzi, Henrique L. |
| author_facet |
Lenzi, Henrique L. Kimmel, Eitan Schechtman, Helio Machado, Marcelo Pelajo Romanha, Waldemiro S. Pacheco, Ronaldo G. Mariano, Mario Lenzi, Jane A. |
| author_role |
author |
| author2 |
Kimmel, Eitan Schechtman, Helio Machado, Marcelo Pelajo Romanha, Waldemiro S. Pacheco, Ronaldo G. Mariano, Mario Lenzi, Jane A. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lenzi, Henrique L. Kimmel, Eitan Schechtman, Helio Machado, Marcelo Pelajo Romanha, Waldemiro S. Pacheco, Ronaldo G. Mariano, Mario Lenzi, Jane A. |
| dc.subject.other.pt_BR.fl_str_mv |
Schistosoma mansoni Granuloma Biomecânica Fibrose Matriz extracelular Microscopia confocal a laser |
| topic |
Schistosoma mansoni Granuloma Biomecânica Fibrose Matriz extracelular Microscopia confocal a laser Schistosoma mansoni Granuloma Biomechanics Fibrosis Extracellular matrix Laser confocal microscopy |
| dc.subject.en.pt_BR.fl_str_mv |
Schistosoma mansoni Granuloma Biomechanics Fibrosis Extracellular matrix Laser confocal microscopy |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. |
| publishDate |
1998 |
| dc.date.issued.fl_str_mv |
1998 |
| dc.date.accessioned.fl_str_mv |
2019-11-12T10:44:15Z |
| dc.date.available.fl_str_mv |
2019-11-12T10:44:15Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
LENZI, Henrique L. et al. Histoarchitecture of Schistosomal Granuloma Development and Involution: Morphogenetic and Biomechanical Approaches. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 93, Suppl. 1, p. 141-151, 1998. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/36986 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/s0074-02761998000700020 |
| dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
| identifier_str_mv |
LENZI, Henrique L. et al. Histoarchitecture of Schistosomal Granuloma Development and Involution: Morphogenetic and Biomechanical Approaches. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 93, Suppl. 1, p. 141-151, 1998. 0074-0276 10.1590/s0074-02761998000700020 1678-8060 |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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