CD16 monocytes in human cutaneous leishmaniasis: increased ex vivo levels and correlation with clinical data
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1189/jlb.0105040 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/2651 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil |
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Soares, GeorgeBarral, Aldina Maria PradoCosta, Jackson Mauricio LopesBarral Netto, ManoelWeyenbergh, Johan Van2011-05-11T19:44:15Z2011-05-11T19:44:15Z2005SOARES, G. et al. CD16 monocytes in human cutaneous leishmaniasis: increased ex vivo levels and correlation with clinical data. Journal of Leukocyte Biology, v. 79, n. 1, p.36-39. jan., 2005.0741-5400https://www.arca.fiocruz.br/handle/icict/265110.1189/jlb.0105040engCD16 monocytes in human cutaneous leishmaniasis: increased ex vivo levels and correlation with clinical datainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilPeripheral blood CD16 (Fc receptor for immunoglobulin G III)-positive monocytes have been shown to expand in different pathological conditions, such as cancer, asthma, sepsis, human immunodeficiency virus infection, and AIDS progression, but data in leishmaniasis are lacking. We found that cutaneous leishmaniasis patients (n = 15) displayed a significant increase in the percentage (3.5 vs. 10.1) as well as mean fluorescent intensity (13.5 vs. 29.2) of ex vivo CD16 expression in monocytes as compared with healthy controls. We observed a significant positive correlation between the percentage of ex vivo CD16+ monocytes and lesion size (P = 0.0052, r = 0.75) or active transforming growth factor-beta plasma levels (P = 0.0017, r = 0.78). In addition, two patients with nonhealing lesions during a 3-year follow-up had high (9.1-19.4%) CD16 levels at diagnosis. Our data suggest a deleterious role for CD16 in human leishmaniasis, as well as its possible use as a marker for disease severity and/or adverse disease outcome.LeishmaniaTGF- BFc receptorWhole bloodLesion sizeLeishmaniose CutâneaMonócitosReceptores de IgGRegulação da Expressão GênicaSíndrome de Imunodeficiência AdquiridaNeoplasiasAntígenos CDMarcadores Biológicosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSoares G CD16+monocytes....pdfSoares G CD16+monocytes....pdfapplication/pdf158139https://www.arca.fiocruz.br/bitstream/icict/2651/1/Soares%20G%20CD16%2bmonocytes....pdf7d75687887571197a71b8c245654ddbbMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2651/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTSoares G CD16+monocytes....pdf.txtSoares G CD16+monocytes....pdf.txtExtracted texttext/plain18892https://www.arca.fiocruz.br/bitstream/icict/2651/5/Soares%20G%20CD16%2bmonocytes....pdf.txtcace94ed0b991c0f64804c43ae622afbMD55THUMBNAILSoares G CD16+monocytes....pdf.jpgSoares G CD16+monocytes....pdf.jpgGenerated Thumbnailimage/jpeg2560https://www.arca.fiocruz.br/bitstream/icict/2651/4/Soares%20G%20CD16%2bmonocytes....pdf.jpgfd58601866277c97ad9f08163c1ef680MD54icict/26512023-03-15 14:33:57.069oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
CD16 monocytes in human cutaneous leishmaniasis: increased ex vivo levels and correlation with clinical data |
| title |
CD16 monocytes in human cutaneous leishmaniasis: increased ex vivo levels and correlation with clinical data |
| spellingShingle |
CD16 monocytes in human cutaneous leishmaniasis: increased ex vivo levels and correlation with clinical data Soares, George Leishmania TGF- B Fc receptor Whole blood Lesion size Leishmaniose Cutânea Monócitos Receptores de IgG Regulação da Expressão Gênica Síndrome de Imunodeficiência Adquirida Neoplasias Antígenos CD Marcadores Biológicos |
| title_short |
CD16 monocytes in human cutaneous leishmaniasis: increased ex vivo levels and correlation with clinical data |
| title_full |
CD16 monocytes in human cutaneous leishmaniasis: increased ex vivo levels and correlation with clinical data |
| title_fullStr |
CD16 monocytes in human cutaneous leishmaniasis: increased ex vivo levels and correlation with clinical data |
| title_full_unstemmed |
CD16 monocytes in human cutaneous leishmaniasis: increased ex vivo levels and correlation with clinical data |
| title_sort |
CD16 monocytes in human cutaneous leishmaniasis: increased ex vivo levels and correlation with clinical data |
| author |
Soares, George |
| author_facet |
Soares, George Barral, Aldina Maria Prado Costa, Jackson Mauricio Lopes Barral Netto, Manoel Weyenbergh, Johan Van |
| author_role |
author |
| author2 |
Barral, Aldina Maria Prado Costa, Jackson Mauricio Lopes Barral Netto, Manoel Weyenbergh, Johan Van |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Soares, George Barral, Aldina Maria Prado Costa, Jackson Mauricio Lopes Barral Netto, Manoel Weyenbergh, Johan Van |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmania TGF- B Fc receptor Whole blood Lesion size |
| topic |
Leishmania TGF- B Fc receptor Whole blood Lesion size Leishmaniose Cutânea Monócitos Receptores de IgG Regulação da Expressão Gênica Síndrome de Imunodeficiência Adquirida Neoplasias Antígenos CD Marcadores Biológicos |
| dc.subject.decs.pt_BR.fl_str_mv |
Leishmaniose Cutânea Monócitos Receptores de IgG Regulação da Expressão Gênica Síndrome de Imunodeficiência Adquirida Neoplasias Antígenos CD Marcadores Biológicos |
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Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil |
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2005 |
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2005 |
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2011-05-11T19:44:15Z |
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2011-05-11T19:44:15Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SOARES, G. et al. CD16 monocytes in human cutaneous leishmaniasis: increased ex vivo levels and correlation with clinical data. Journal of Leukocyte Biology, v. 79, n. 1, p.36-39. jan., 2005. |
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https://www.arca.fiocruz.br/handle/icict/2651 |
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0741-5400 |
| dc.identifier.doi.none.fl_str_mv |
10.1189/jlb.0105040 |
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SOARES, G. et al. CD16 monocytes in human cutaneous leishmaniasis: increased ex vivo levels and correlation with clinical data. Journal of Leukocyte Biology, v. 79, n. 1, p.36-39. jan., 2005. 0741-5400 10.1189/jlb.0105040 |
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