Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/27254 |
Resumo: | Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Bafica, Aline Michelle BarbosaCardoso, Luciana SantosOliveira, Sérgio CostaLoukas, AlexGóes, AlfredoOliveira, Ricardo RiccioCarvalho Filho, Edgar MarcelinoAraujo, Maria Ilma2018-07-03T18:39:25Z2018-07-03T18:39:25Z2012BAFICA, A. M. B. et al. Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients. Journal of Parasitology Research, Article ID 520308, 2012.2090-0023https://www.arca.fiocruz.br/handle/icict/2725410.1155/2012/520308Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Brazilian National Research Council (CNPq) and by the NIH Grant no. NIH AI 088650.Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Instituto Nacional de Ciˆencia e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilJames Cook University. School of Public Health and Tropical Medicine. Queensland Tropical Health Alliance. Cairns, AustraliaUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilHigh levels of proinflammatory cytokines such as IFN-γ and TNF are associated with tissue lesions in cutaneous leishmaniasis (CL). We previously demonstrated that Schistosoma mansoni antigens downmodulate the in vitro cytokine response in CL. In the current study we evaluated whether S. mansoni antigens alter monocyte and T-lymphocyte phenotypes in leishmaniasis. Peripheral blood mononuclear cells of CL patients were cultured with L. braziliensis antigen in the presence or absence of the S. mansoni antigens rSm29, rSmTSP-2- and PIII. Cells were stained with fluorochrome conjugated antibodies and analyzed by flow cytometry. The addition of rSm29 to the cultures decreased the expression of HLA-DR in nonclassical (CD14(+)CD16(++)) monocytes, while the addition of PIII diminished the expression of this molecule in classical (CD14(++)CD16(-)) and intermediate (CD14(++)CD16(+)) monocytes. The addition of PIII and rSmTSP-2 resulted in downmodulation of CD80 expression in nonclassical and CD86 expression in intermediate monocytes, respectively. These two antigens increased the expression of CTLA-4 in CD4(+) T cells and they also expanded the frequency of CD4(+)CD25(high)Foxp3(+) T cells. Taken together, we show that S. mansoni antigens, mainly rSmTSP-2 and PIII, are able to decrease the activation status of monocytes and also to upregulate the expression of modulatory molecules in T lymphocytes.engHindawi Publishing CorporationSchistosoma mansoniLeishmaniose TegumentarCélulas TMonócitosLeishmaniose cutâneaAntígenosSchistosoma mansoniTegumentary leishmaniasisT-CellMonocyteCutaneous leishmaniasisAntigensChanges in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27254/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBafica AMB Changes in T-Cell and Monocyte Phenotypes.pdfBafica AMB Changes in T-Cell 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dc.title.pt_BR.fl_str_mv |
Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients |
title |
Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients |
spellingShingle |
Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients Bafica, Aline Michelle Barbosa Schistosoma mansoni Leishmaniose Tegumentar Células T Monócitos Leishmaniose cutânea Antígenos Schistosoma mansoni Tegumentary leishmaniasis T-Cell Monocyte Cutaneous leishmaniasis Antigens |
title_short |
Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients |
title_full |
Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients |
title_fullStr |
Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients |
title_full_unstemmed |
Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients |
title_sort |
Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients |
author |
Bafica, Aline Michelle Barbosa |
author_facet |
Bafica, Aline Michelle Barbosa Cardoso, Luciana Santos Oliveira, Sérgio Costa Loukas, Alex Góes, Alfredo Oliveira, Ricardo Riccio Carvalho Filho, Edgar Marcelino Araujo, Maria Ilma |
author_role |
author |
author2 |
Cardoso, Luciana Santos Oliveira, Sérgio Costa Loukas, Alex Góes, Alfredo Oliveira, Ricardo Riccio Carvalho Filho, Edgar Marcelino Araujo, Maria Ilma |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Bafica, Aline Michelle Barbosa Cardoso, Luciana Santos Oliveira, Sérgio Costa Loukas, Alex Góes, Alfredo Oliveira, Ricardo Riccio Carvalho Filho, Edgar Marcelino Araujo, Maria Ilma |
dc.subject.other.pt_BR.fl_str_mv |
Schistosoma mansoni Leishmaniose Tegumentar Células T Monócitos Leishmaniose cutânea Antígenos |
topic |
Schistosoma mansoni Leishmaniose Tegumentar Células T Monócitos Leishmaniose cutânea Antígenos Schistosoma mansoni Tegumentary leishmaniasis T-Cell Monocyte Cutaneous leishmaniasis Antigens |
dc.subject.en.pt_BR.fl_str_mv |
Schistosoma mansoni Tegumentary leishmaniasis T-Cell Monocyte Cutaneous leishmaniasis Antigens |
description |
Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2018-07-03T18:39:25Z |
dc.date.available.fl_str_mv |
2018-07-03T18:39:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BAFICA, A. M. B. et al. Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients. Journal of Parasitology Research, Article ID 520308, 2012. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/27254 |
dc.identifier.issn.pt_BR.fl_str_mv |
2090-0023 |
dc.identifier.doi.none.fl_str_mv |
10.1155/2012/520308 |
identifier_str_mv |
BAFICA, A. M. B. et al. Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients. Journal of Parasitology Research, Article ID 520308, 2012. 2090-0023 10.1155/2012/520308 |
url |
https://www.arca.fiocruz.br/handle/icict/27254 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
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Hindawi Publishing Corporation |
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