Oral Route Driven Acute Trypanosoma cruzi Infection Unravels an IL-6 Dependent Hemostatic Derangement

Detalhes bibliográficos
Autor(a) principal: Antunes, Dina
Data de Publicação: 2019
Outros Autores: Santos, Alessandro Marins dos, Ramos, Mariana Tavares, Mascarenhas, Barbara Angelica S., Moreira, Carlos José de Carvalho, Oliveira, Désio Aurélio Farias de, Savino, Wilson, Monteiro, Robson Q., Meis, Juliana de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33842
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de CIência e Tecnologia em NeuroimunoModulação. Rio de Janeiro, RJ, Brasil.
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spelling Antunes, DinaSantos, Alessandro Marins dosRamos, Mariana TavaresMascarenhas, Barbara Angelica S.Moreira, Carlos José de CarvalhoOliveira, Désio Aurélio Farias deSavino, WilsonMonteiro, Robson Q.Meis, Juliana de2019-07-04T15:30:53Z2019-07-04T15:30:53Z2019ANTUNES, Dina et al. Oral Route Driven Acute Trypanosoma cruzi Infection Unravels an IL-6 Dependent Hemostatic Derangement. Frontiers in Immunology, v. 10, Article 1073, p. 1-10, May 2019.1664-3224https://www.arca.fiocruz.br/handle/icict/3384210.3389/fimmu.2019.01073engFrontiers MediaTrypanosoma cruziDoença de ChagasCitocinasCoagulaçãoInterleucina-6PlaquetasChagas disease,Oral transmissionCytokinePlateletCoagulationInterleukin-6Interleucina-6Oral Route Driven Acute Trypanosoma cruzi Infection Unravels an IL-6 Dependent Hemostatic Derangementinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de CIência e Tecnologia em NeuroimunoModulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de CIência e Tecnologia em NeuroimunoModulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de CIência e Tecnologia em NeuroimunoModulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de CIência e Tecnologia em NeuroimunoModulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ. Brasil.undação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de CIência e Tecnologia em NeuroimunoModulação. Rio de Janeiro, RJ, Brasil.undação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de CIência e Tecnologia em NeuroimunoModulação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.undação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de CIência e Tecnologia em NeuroimunoModulação. Rio de Janeiro, RJ, Brasil.Oral transmission of Trypanosoma cruzi, the etiologic agent of Chagas disease, is presently the most important route of infection in Brazilian Amazon. Other South American countries have also reported outbreaks of acute Chagas disease associated with food consumption. A conspicuous feature of this route of transmission is presenting symptoms such as facial and lower limbs edema, in some cases bleeding manifestations and risk of thromboembolism are evident. Notwithstanding, studies that address this route of infection are largely lacking regarding its pathogenesis and, more specifically, the crosstalk between immune and hemostatic systems. Here, BALB/c mice were orally infected with metacyclic trypomastigotes of T. cruzi Tulahuén strain and used to evaluate the cytokine response, primary and secondary hemostasis during acute T. cruzi infection. When compared with control uninfected animals, orally infected mice presented higher pro-inflammatory cytokine (TNF-α, IFN-γ, and IL-6) serum levels. The highest concentrations were obtained concomitantly to the increase of parasitemia, between 14 and 28 days post-infection (dpi). Blood counts in the oral infected group revealed concomitant leukocytosis and thrombocytopenia, the latter resulting in increased bleeding at 21 dpi. Hematological changes paralleled with prolonged activated partial thromboplastin time, Factor VIII consumption and increased D-dimer levels, suggest that oral T. cruzi infection relies on disseminated intravascular coagulation. Remarkably, blockade of the IL-6 receptor blunted hematological abnormalities, revealing a critical role of IL-6 in the course of oral infection. These results unravel that acute T. cruzi oral infection results in significant alterations in the hemostatic system and indicates the relevance of the crosstalk between inflammation and hemostasis in this parasitic disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33842/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALWilsonSavino_DinaAntunes_etal_IOC_2019.pdfWilsonSavino_DinaAntunes_etal_IOC_2019.pdfapplication/pdf2958086https://www.arca.fiocruz.br/bitstream/icict/33842/2/WilsonSavino_DinaAntunes_etal_IOC_2019.pdf06fc5810e00b55cc4b92335c1120548bMD52TEXTWilsonSavino_DinaAntunes_etal_IOC_2019.pdf.txtWilsonSavino_DinaAntunes_etal_IOC_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Oral Route Driven Acute Trypanosoma cruzi Infection Unravels an IL-6 Dependent Hemostatic Derangement
title Oral Route Driven Acute Trypanosoma cruzi Infection Unravels an IL-6 Dependent Hemostatic Derangement
spellingShingle Oral Route Driven Acute Trypanosoma cruzi Infection Unravels an IL-6 Dependent Hemostatic Derangement
Antunes, Dina
Trypanosoma cruzi
Doença de Chagas
Citocinas
Coagulação
Interleucina-6
Plaquetas
Chagas disease,
Oral transmission
Cytokine
Platelet
Coagulation
Interleukin-6
Interleucina-6
title_short Oral Route Driven Acute Trypanosoma cruzi Infection Unravels an IL-6 Dependent Hemostatic Derangement
title_full Oral Route Driven Acute Trypanosoma cruzi Infection Unravels an IL-6 Dependent Hemostatic Derangement
title_fullStr Oral Route Driven Acute Trypanosoma cruzi Infection Unravels an IL-6 Dependent Hemostatic Derangement
title_full_unstemmed Oral Route Driven Acute Trypanosoma cruzi Infection Unravels an IL-6 Dependent Hemostatic Derangement
title_sort Oral Route Driven Acute Trypanosoma cruzi Infection Unravels an IL-6 Dependent Hemostatic Derangement
author Antunes, Dina
author_facet Antunes, Dina
Santos, Alessandro Marins dos
Ramos, Mariana Tavares
Mascarenhas, Barbara Angelica S.
Moreira, Carlos José de Carvalho
Oliveira, Désio Aurélio Farias de
Savino, Wilson
Monteiro, Robson Q.
Meis, Juliana de
author_role author
author2 Santos, Alessandro Marins dos
Ramos, Mariana Tavares
Mascarenhas, Barbara Angelica S.
Moreira, Carlos José de Carvalho
Oliveira, Désio Aurélio Farias de
Savino, Wilson
Monteiro, Robson Q.
Meis, Juliana de
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Antunes, Dina
Santos, Alessandro Marins dos
Ramos, Mariana Tavares
Mascarenhas, Barbara Angelica S.
Moreira, Carlos José de Carvalho
Oliveira, Désio Aurélio Farias de
Savino, Wilson
Monteiro, Robson Q.
Meis, Juliana de
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Doença de Chagas
Citocinas
Coagulação
Interleucina-6
Plaquetas
topic Trypanosoma cruzi
Doença de Chagas
Citocinas
Coagulação
Interleucina-6
Plaquetas
Chagas disease,
Oral transmission
Cytokine
Platelet
Coagulation
Interleukin-6
Interleucina-6
dc.subject.en.pt_BR.fl_str_mv Chagas disease,
Oral transmission
Cytokine
Platelet
Coagulation
Interleukin-6
dc.subject.decs.pt_BR.fl_str_mv Interleucina-6
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de CIência e Tecnologia em NeuroimunoModulação. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-07-04T15:30:53Z
dc.date.available.fl_str_mv 2019-07-04T15:30:53Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANTUNES, Dina et al. Oral Route Driven Acute Trypanosoma cruzi Infection Unravels an IL-6 Dependent Hemostatic Derangement. Frontiers in Immunology, v. 10, Article 1073, p. 1-10, May 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33842
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2019.01073
identifier_str_mv ANTUNES, Dina et al. Oral Route Driven Acute Trypanosoma cruzi Infection Unravels an IL-6 Dependent Hemostatic Derangement. Frontiers in Immunology, v. 10, Article 1073, p. 1-10, May 2019.
1664-3224
10.3389/fimmu.2019.01073
url https://www.arca.fiocruz.br/handle/icict/33842
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/33842/2/WilsonSavino_DinaAntunes_etal_IOC_2019.pdf
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