HIV‑1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/48670 |
Resumo: | CNPq (406510/2018-0) |
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Gräf, TiagoBello, GonzaloAndrade, PaulaArantes, IghorPereira, João MarcosSilva, Alexandre Bonfim Pinheiro daVeiga, Rafael V.Mariani, DianaBoullosa, Lídia TheodoroArruda, Mônica B.Fernandez, José Carlos CoutoDennis, Ann M.Rasmussen, David A.Tanuri, Amilcar2021-08-19T13:28:05Z2021-08-19T13:28:05Z2021GRÄF, Tiago et al. HIV‑1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network. Scientific Reports, v. 11, n. 15842, 04 Aug. 2021.2045-2322https://www.arca.fiocruz.br/handle/icict/4867010.1038/s41598-021-94542-5CNPq (406510/2018-0)NIH Office of AIDS Research (OAR)Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biologia. Departamento de Genética. Laboratório de Bioinformática e Evolução Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biologia. Departamento de Genética. Laboratório de Bioinformática e Evolução Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde, Salvador, BA, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.University of North Carolina. Division of Infectious Diseases. Chapel Hill, NC, United States of America.North Carolina State University. Department of Entomology and Plant Pathology. Raleigh, United States of America / North Carolina State University. Bioinformatics Research Center. Raleigh, United States of America.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.HIV-1 has diversifed into several subtypes and recombinant forms that are heterogeneously spread around the world. Understanding the distribution of viral variants and their temporal dynamics can help to design vaccines and monitor changes in viral transmission patterns. Brazil has one of the largest HIV-1 epidemics in the western-world and the molecular features of the virus circulating in the country are still not completely known. Over 50,000 partial HIV-1 genomes sampled between 2008 and 2017 by the Brazilian genotyping network (RENAGENO) were analyzed. Sequences were fltered by quality, duplicate sequences per patient were removed and subtyping was performed with online tools and molecular phylogeny. Association between patients’ demographic data and subtypes were performed by calculating the relative risk in a multinomial analysis and trends in subtype prevalence were tested by Pearson correlation. HIV-1B was found to be the most prevalent subtype throughout the country except in the south, where HIV-1C prevails. An increasing trend in the proportion of HIV-1C and F1 was observed in several regions of the country, while HIV-1B tended to decrease. Men and highly educated individuals were more frequently infected by HIV-1B and non-B variants were more prevalent among women with lower education. Our results suggest that socio-demographic factors partially segregate HIV-1 diversity in Brazil while shaping viral transmission networks. Historical events could explain a preferential circulation of HIV-1B among men who have sex with men (MSM) and non-B variants among heterosexual individuals. In view of an increasing male/female ratio of AIDS cases in Brazil in the last 10–15 years, the decrease of HIV-1B prevalence is surprising and suggests a greater penetrance of non-B subtypes in MSM transmission chains.engNature ResearchHIV-1GenomaHeterossexualidadeSíndrome de Imunodeficiência AdquiridaEpidemiasHIV-1GenomeHeterosexualityAcquired Immunodeficiency SyndromeEpidemicsHIV‑1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping networkinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/48670/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALGraf, Tiago HIV-1 molecular....pdfGraf, Tiago HIV-1 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| dc.title.en.fl_str_mv |
HIV‑1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network |
| title |
HIV‑1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network |
| spellingShingle |
HIV‑1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network Gräf, Tiago HIV-1 Genoma Heterossexualidade Síndrome de Imunodeficiência Adquirida Epidemias HIV-1 Genome Heterosexuality Acquired Immunodeficiency Syndrome Epidemics |
| title_short |
HIV‑1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network |
| title_full |
HIV‑1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network |
| title_fullStr |
HIV‑1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network |
| title_full_unstemmed |
HIV‑1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network |
| title_sort |
HIV‑1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network |
| author |
Gräf, Tiago |
| author_facet |
Gräf, Tiago Bello, Gonzalo Andrade, Paula Arantes, Ighor Pereira, João Marcos Silva, Alexandre Bonfim Pinheiro da Veiga, Rafael V. Mariani, Diana Boullosa, Lídia Theodoro Arruda, Mônica B. Fernandez, José Carlos Couto Dennis, Ann M. Rasmussen, David A. Tanuri, Amilcar |
| author_role |
author |
| author2 |
Bello, Gonzalo Andrade, Paula Arantes, Ighor Pereira, João Marcos Silva, Alexandre Bonfim Pinheiro da Veiga, Rafael V. Mariani, Diana Boullosa, Lídia Theodoro Arruda, Mônica B. Fernandez, José Carlos Couto Dennis, Ann M. Rasmussen, David A. Tanuri, Amilcar |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gräf, Tiago Bello, Gonzalo Andrade, Paula Arantes, Ighor Pereira, João Marcos Silva, Alexandre Bonfim Pinheiro da Veiga, Rafael V. Mariani, Diana Boullosa, Lídia Theodoro Arruda, Mônica B. Fernandez, José Carlos Couto Dennis, Ann M. Rasmussen, David A. Tanuri, Amilcar |
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HIV-1 Genoma Heterossexualidade Síndrome de Imunodeficiência Adquirida Epidemias |
| topic |
HIV-1 Genoma Heterossexualidade Síndrome de Imunodeficiência Adquirida Epidemias HIV-1 Genome Heterosexuality Acquired Immunodeficiency Syndrome Epidemics |
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HIV-1 Genome Heterosexuality Acquired Immunodeficiency Syndrome Epidemics |
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CNPq (406510/2018-0) |
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2021 |
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2021-08-19T13:28:05Z |
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2021 |
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GRÄF, Tiago et al. HIV‑1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network. Scientific Reports, v. 11, n. 15842, 04 Aug. 2021. |
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https://www.arca.fiocruz.br/handle/icict/48670 |
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10.1038/s41598-021-94542-5 |
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GRÄF, Tiago et al. HIV‑1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network. Scientific Reports, v. 11, n. 15842, 04 Aug. 2021. 2045-2322 10.1038/s41598-021-94542-5 |
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