Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14841 |
Resumo: | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil/University of Massachusetts Medical School. Department of Medicine. Worcester, MA, United States of America/Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brasil. |
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Rocha, Bruno CoelhoMarques, Pedro EliasLeoratti, Fabiana Maria de SouzaJunqueira, CarolinePereira, Dhelio BatistaAntonelli, Lis Ribeiro do ValleMenezes, Gustavo BatistaGolenbock, Douglas TaylorGazzinelli, Ricardo Tostes2016-07-13T12:50:22Z2016-07-13T12:50:22Z2015ROCHA, Bruno Coelho et al. Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria. Cell Rep., vol. 13, n. 12, p. 2829–2841, 2015.2211-1247https://www.arca.fiocruz.br/handle/icict/1484110.1016/j.celrep.2015.11.055engElsevier IncType I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil/University of Massachusetts Medical School. Department of Medicine. Worcester, MA, United States of America/Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais.Instituto de Ciencias Biologicas. Departamento de Morfologia. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas em Medicina Tropical. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais.Instituto de Ciencias Biologicas. Departamento de Morfologia. Belo Horizonte, MG, Brasil.University of Massachusetts Medical School. Department of Medicine. Worcester, MA, United States of America.Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil/University of Massachusetts Medical School. Department of Medicine. Worcester, MA, United States of America/Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brasil.Neutrophils are the most abundant leukocyte population in the bloodstream, the primary compartment of Plasmodium sp. infection. Yet, the role of these polymorphonuclear cells in mediating either resistance or pathogenesis of malaria is poorly understood. We report that circulating neutrophils from malaria patients are highly activated, as indicated by a strong type I interferon transcriptional signature, increased expression of surface activation markers, the enhanced release of reactive oxygen species and myeloperoxidase, as well as the high frequency of low-density granulocytes. The activation of neutrophils was associated with increased levels of serum alanine and aspartate aminotransferases, indicating liver damage. In a rodent malaria model, we observed an intense recruitment of neutrophils to liver sinusoids. Neutrophil migration, IL-1β and chemokine expression as well as liver damage were all dependent on type I interferon signaling. The data suggests that type I interferon signaling have a central role in neutrophil activation and malaria pathogenesisPlasmodium spmalariainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14841/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve _Rocha_Bruno_Type_CPqRR_2015.pdfve _Rocha_Bruno_Type_CPqRR_2015.pdfapplication/pdf1298835https://www.arca.fiocruz.br/bitstream/icict/14841/2/ve%20_Rocha_Bruno_Type_CPqRR_2015.pdf011cae42c4eb04584bc956e3c03a7867MD52TEXTve _Rocha_Bruno_Type_CPqRR_2015.pdf.txtve _Rocha_Bruno_Type_CPqRR_2015.pdf.txtExtracted texttext/plain62515https://www.arca.fiocruz.br/bitstream/icict/14841/3/ve%20_Rocha_Bruno_Type_CPqRR_2015.pdf.txte06f3aaa2b0931af9106f0aaea2a0185MD53icict/148412019-06-19 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| dc.title.pt_BR.fl_str_mv |
Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria |
| title |
Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria |
| spellingShingle |
Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria Rocha, Bruno Coelho Plasmodium sp malaria |
| title_short |
Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria |
| title_full |
Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria |
| title_fullStr |
Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria |
| title_full_unstemmed |
Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria |
| title_sort |
Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria |
| author |
Rocha, Bruno Coelho |
| author_facet |
Rocha, Bruno Coelho Marques, Pedro Elias Leoratti, Fabiana Maria de Souza Junqueira, Caroline Pereira, Dhelio Batista Antonelli, Lis Ribeiro do Valle Menezes, Gustavo Batista Golenbock, Douglas Taylor Gazzinelli, Ricardo Tostes |
| author_role |
author |
| author2 |
Marques, Pedro Elias Leoratti, Fabiana Maria de Souza Junqueira, Caroline Pereira, Dhelio Batista Antonelli, Lis Ribeiro do Valle Menezes, Gustavo Batista Golenbock, Douglas Taylor Gazzinelli, Ricardo Tostes |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rocha, Bruno Coelho Marques, Pedro Elias Leoratti, Fabiana Maria de Souza Junqueira, Caroline Pereira, Dhelio Batista Antonelli, Lis Ribeiro do Valle Menezes, Gustavo Batista Golenbock, Douglas Taylor Gazzinelli, Ricardo Tostes |
| dc.subject.en.pt_BR.fl_str_mv |
Plasmodium sp malaria |
| topic |
Plasmodium sp malaria |
| description |
Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil/University of Massachusetts Medical School. Department of Medicine. Worcester, MA, United States of America/Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brasil. |
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2015 |
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2015 |
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2016-07-13T12:50:22Z |
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2016-07-13T12:50:22Z |
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ROCHA, Bruno Coelho et al. Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria. Cell Rep., vol. 13, n. 12, p. 2829–2841, 2015. |
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https://www.arca.fiocruz.br/handle/icict/14841 |
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2211-1247 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.celrep.2015.11.055 |
| identifier_str_mv |
ROCHA, Bruno Coelho et al. Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria. Cell Rep., vol. 13, n. 12, p. 2829–2841, 2015. 2211-1247 10.1016/j.celrep.2015.11.055 |
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