Malaria primes the innate immune response due to interferon-y induced enhancement of toll-like receptor expression and function
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/1915 |
Resumo: | Fundação Oswaldo Cruz. René Rachou Institute. Immunopathology Laboratory. Belo Horizonte, MG, Brazil. |
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Franklin, Bernardo SimõesParroche, PeggyAtaíde, Marco AntônioLauw, FannyRopert, CatherineOliveira, Rosane B. dePereira, DhelioTada, Mauro ShugiroNogueira, Paulo AfonsoSilva, Luiz Hildebrando Pereira daBjorkbacka, HarryGolenbock, Douglas TaylorGazzinelli, Ricardo T.2011-04-15T01:09:00Z2011-04-15T01:09:00Z2009FRANKLIN, Bernardo Simões et al. Malaria primes the innate immune response due to interferon-_ induced enhancement of toll-like receptor expression and function. Proceedings Of The Nacional Academy Of Sciences Of Teh United States Of America, v. 106, n. 14, p. 5789-5794, Apr. 7, 2009.0027-8424https://www.arca.fiocruz.br/handle/icict/191510.1073/pnas.0809742106engMalaria primes the innate immune response due to interferon-y induced enhancement of toll-like receptor expression and functioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. René Rachou Institute. Immunopathology Laboratory. Belo Horizonte, MG, Brazil.University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Massachusetts, USA.Fundação Oswaldo Cruz. René Rachou Institute. Immunopathology Laboratory. Belo Horizonte, MG, Brazil.University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Massachusetts, USA.Fundação Oswaldo Cruz. René Rachou Institute. Immunopathology Laboratory. Belo Horizonte, MG, Brazil.University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Massachusetts, USA.Centro de Pesquisas em Medicina Tropical de Rondônia. Porto Velho, RO, Brazil.Centro de Pesquisas em Medicina Tropical de Rondônia. Porto Velho, RO, Brazil.Centro de Pesquisas em Medicina Tropical de Rondônia. Porto Velho, RO, Brazil.Centro de Pesquisas em Medicina Tropical de Rondônia. Porto Velho, RO, Brazil.University of Minas Gerais. Experimental Cardiovascular Research. Lund University Malmo Sweden / Department of Biochemistry and Immunology, Biological Sciences Institute, Federal. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. René Rachou Institute. Immunopathology Laboratory. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. René Rachou Institute. Immunopathology Laboratory. Belo Horizonte, MG, Brazil.Malaria-induced sepsis is associated with an intense proinflammatory cytokinemia for which the underlying mechanisms are poorly understood. It has been demonstrated that experimental infection of humans with Plasmodium falciparum primes Toll-like receptor (TLR)-mediated proinflammatory responses. Nevertheless, the relevance of this phenomenon during natural infection and, more importantly, the mechanisms by which malaria mediates TLR hyperresponsiveness are unclear. Here we show that TLR responses are boosted in febrile patients during natural infection with P. falciparum. Microarray analyses demonstrated that an extraordinary percentage of the up-regulated genes, including genes involving TLR signaling, had sites for IFN-inducible transcription factors. To further define the mechanism involved in malariamediated ‘‘priming,’’ we infected mice with Plasmodium chabaudi. The human data were remarkably predictive of what we observed in the rodent malaria model. Malaria-induced priming of TLR responses correlated with increased expression of TLR mRNA in a TLR9-, MyD88-, and IFN -dependent manner. Acutely infected WT mice were highly susceptible to LPS-induced lethality while TLR9/, IL12/ and to a greater extent, IFN / mice were protected. Our data provide unprecedented evidence that TLR9 and MyD88 are essential to initiate IL12 and IFN responses and favor host hyperresponsiveness to TLR agonists resulting in overproduction of proinflammatory cytokines and the sepsis-like symptoms of acute malaria.MalariaPlasmodium falciparum primesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMalaria primes the innate immune.pdfMalaria primes the innate immune.pdfapplication/pdf627306https://www.arca.fiocruz.br/bitstream/icict/1915/1/Malaria%20primes%20the%20innate%20immune.pdf4c473bd747625960e075afce30358451MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/1915/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTMalaria primes the innate immune.pdf.txtMalaria primes the innate immune.pdf.txtExtracted texttext/plain44196https://www.arca.fiocruz.br/bitstream/icict/1915/5/Malaria%20primes%20the%20innate%20immune.pdf.txt72b22e39ae9ddcdaf03d4ba8283b48c8MD55THUMBNAILMalaria primes the innate immune.pdf.jpgMalaria primes the innate immune.pdf.jpgGenerated Thumbnailimage/jpeg2612https://www.arca.fiocruz.br/bitstream/icict/1915/4/Malaria%20primes%20the%20innate%20immune.pdf.jpg1644cd497164140337c1598950021538MD54icict/19152020-05-25 20:02:50.516oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352020-05-25T23:02:50Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Malaria primes the innate immune response due to interferon-y induced enhancement of toll-like receptor expression and function |
| title |
Malaria primes the innate immune response due to interferon-y induced enhancement of toll-like receptor expression and function |
| spellingShingle |
Malaria primes the innate immune response due to interferon-y induced enhancement of toll-like receptor expression and function Franklin, Bernardo Simões Malaria Plasmodium falciparum primes |
| title_short |
Malaria primes the innate immune response due to interferon-y induced enhancement of toll-like receptor expression and function |
| title_full |
Malaria primes the innate immune response due to interferon-y induced enhancement of toll-like receptor expression and function |
| title_fullStr |
Malaria primes the innate immune response due to interferon-y induced enhancement of toll-like receptor expression and function |
| title_full_unstemmed |
Malaria primes the innate immune response due to interferon-y induced enhancement of toll-like receptor expression and function |
| title_sort |
Malaria primes the innate immune response due to interferon-y induced enhancement of toll-like receptor expression and function |
| author |
Franklin, Bernardo Simões |
| author_facet |
Franklin, Bernardo Simões Parroche, Peggy Ataíde, Marco Antônio Lauw, Fanny Ropert, Catherine Oliveira, Rosane B. de Pereira, Dhelio Tada, Mauro Shugiro Nogueira, Paulo Afonso Silva, Luiz Hildebrando Pereira da Bjorkbacka, Harry Golenbock, Douglas Taylor Gazzinelli, Ricardo T. |
| author_role |
author |
| author2 |
Parroche, Peggy Ataíde, Marco Antônio Lauw, Fanny Ropert, Catherine Oliveira, Rosane B. de Pereira, Dhelio Tada, Mauro Shugiro Nogueira, Paulo Afonso Silva, Luiz Hildebrando Pereira da Bjorkbacka, Harry Golenbock, Douglas Taylor Gazzinelli, Ricardo T. |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Franklin, Bernardo Simões Parroche, Peggy Ataíde, Marco Antônio Lauw, Fanny Ropert, Catherine Oliveira, Rosane B. de Pereira, Dhelio Tada, Mauro Shugiro Nogueira, Paulo Afonso Silva, Luiz Hildebrando Pereira da Bjorkbacka, Harry Golenbock, Douglas Taylor Gazzinelli, Ricardo T. |
| dc.subject.en.pt_BR.fl_str_mv |
Malaria Plasmodium falciparum primes |
| topic |
Malaria Plasmodium falciparum primes |
| description |
Fundação Oswaldo Cruz. René Rachou Institute. Immunopathology Laboratory. Belo Horizonte, MG, Brazil. |
| publishDate |
2009 |
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2009 |
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2011-04-15T01:09:00Z |
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2011-04-15T01:09:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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FRANKLIN, Bernardo Simões et al. Malaria primes the innate immune response due to interferon-_ induced enhancement of toll-like receptor expression and function. Proceedings Of The Nacional Academy Of Sciences Of Teh United States Of America, v. 106, n. 14, p. 5789-5794, Apr. 7, 2009. |
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https://www.arca.fiocruz.br/handle/icict/1915 |
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0027-8424 |
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10.1073/pnas.0809742106 |
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FRANKLIN, Bernardo Simões et al. Malaria primes the innate immune response due to interferon-_ induced enhancement of toll-like receptor expression and function. Proceedings Of The Nacional Academy Of Sciences Of Teh United States Of America, v. 106, n. 14, p. 5789-5794, Apr. 7, 2009. 0027-8424 10.1073/pnas.0809742106 |
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