Treatment of acute experimental schistosomiasis

Detalhes bibliográficos
Autor(a) principal: Andrade, Zilton de Araújo
Data de Publicação: 1989
Outros Autores: Carmo, Theomira Mauadie de Azevedo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5725
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
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spelling Andrade, Zilton de AraújoCarmo, Theomira Mauadie de Azevedo2012-10-23T19:25:47Z2012-10-23T19:25:47Z1989ANDRADE, Zilton de Araújo; CARMO, Theomira Mauadie de Azevedo. Treatment of acute experimental schistosomiasis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 84, n. 4, p. 477-484, Oct./Dec. 1989.0074-0276https://www.arca.fiocruz.br/handle/icict/572510.1590/S0074-02761989000400004engTreatment of acute experimental schistosomiasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.A model of acute schistosomiasis of the mouse was used to observe whether curative treatment would be followed by an enhancement of the hepatic and splenic lesions, as a consequence of the massive destruction of worms and eggs within the portal system. Mice infected with 50 cercariae of Schistosoma mansoni were treated with both oxamniquine and praziquantel on the 50th day of infection and submitted to a sequential histologic examination from the 2nd to the 45th day after treatment. Although severe focal lesions due to dead and disintegrating worms were present in the livers of the treated animals, no aggravation of the general changes (reactive hepatitis and splenitis, or periovular granulomas) was seen in comparison with a control non-treated group. Of 50 animals treated during the acute phase of schistosomiasis only one died spontaneously, while 16 out of 30 infected controls died before the end of the experiment. The present investigation indicates that curative treatment during the acute phase of schistosomiasis does not enhance previous lesions at first and results in progressive disappearance of the lesions starting six days following chemotherapy.Acute schistosomiasisChemotherapyHepatic and splenic lesionsSchistosoma mansoniHepatopatias Parasitárias/quimioterapiaOxamniquine/uso terapêuticoPraziquantel/uso terapêuticoEsquistossomose/quimioterapiaEsplenopatias/quimioterapiaDoença AgudaAnimaisFemininoGranuloma/parasitologiaHepatopatias Parasitárias/patologiaMasculinoCamundongosEsquistossomose/patologiaEsplenopatias/patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade Za Treatment of acute experimental....pdfAndrade Za Treatment of acute experimental....pdfapplication/pdf495911https://www.arca.fiocruz.br/bitstream/icict/5725/1/Andrade%20Za%20Treatment%20of%20acute%20experimental....pdf285d624c3246850bf035f4928978d5e7MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5725/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTAndrade Za Treatment of acute experimental....pdf.txtAndrade Za Treatment of acute experimental....pdf.txtExtracted texttext/plain8https://www.arca.fiocruz.br/bitstream/icict/5725/5/Andrade%20Za%20Treatment%20of%20acute%20experimental....pdf.txt8d1b69dd9bdc9df4a8073c7a8193c7afMD55THUMBNAILAndrade Za Treatment of acute experimental....pdf.jpgAndrade Za Treatment of acute experimental....pdf.jpgGenerated Thumbnailimage/jpeg2567https://www.arca.fiocruz.br/bitstream/icict/5725/4/Andrade%20Za%20Treatment%20of%20acute%20experimental....pdf.jpg17b07a06c4374208ed4995641b3a53caMD54icict/57252023-03-15 14:32:58.495oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Treatment of acute experimental schistosomiasis
title Treatment of acute experimental schistosomiasis
spellingShingle Treatment of acute experimental schistosomiasis
Andrade, Zilton de Araújo
Acute schistosomiasis
Chemotherapy
Hepatic and splenic lesions
Schistosoma mansoni
Hepatopatias Parasitárias/quimioterapia
Oxamniquine/uso terapêutico
Praziquantel/uso terapêutico
Esquistossomose/quimioterapia
Esplenopatias/quimioterapia
Doença Aguda
Animais
Feminino
Granuloma/parasitologia
Hepatopatias Parasitárias/patologia
Masculino
Camundongos
Esquistossomose/patologia
Esplenopatias/patologia
title_short Treatment of acute experimental schistosomiasis
title_full Treatment of acute experimental schistosomiasis
title_fullStr Treatment of acute experimental schistosomiasis
title_full_unstemmed Treatment of acute experimental schistosomiasis
title_sort Treatment of acute experimental schistosomiasis
author Andrade, Zilton de Araújo
author_facet Andrade, Zilton de Araújo
Carmo, Theomira Mauadie de Azevedo
author_role author
author2 Carmo, Theomira Mauadie de Azevedo
author2_role author
dc.contributor.author.fl_str_mv Andrade, Zilton de Araújo
Carmo, Theomira Mauadie de Azevedo
dc.subject.en.pt_BR.fl_str_mv Acute schistosomiasis
Chemotherapy
Hepatic and splenic lesions
Schistosoma mansoni
topic Acute schistosomiasis
Chemotherapy
Hepatic and splenic lesions
Schistosoma mansoni
Hepatopatias Parasitárias/quimioterapia
Oxamniquine/uso terapêutico
Praziquantel/uso terapêutico
Esquistossomose/quimioterapia
Esplenopatias/quimioterapia
Doença Aguda
Animais
Feminino
Granuloma/parasitologia
Hepatopatias Parasitárias/patologia
Masculino
Camundongos
Esquistossomose/patologia
Esplenopatias/patologia
dc.subject.decs.pt_BR.fl_str_mv Hepatopatias Parasitárias/quimioterapia
Oxamniquine/uso terapêutico
Praziquantel/uso terapêutico
Esquistossomose/quimioterapia
Esplenopatias/quimioterapia
Doença Aguda
Animais
Feminino
Granuloma/parasitologia
Hepatopatias Parasitárias/patologia
Masculino
Camundongos
Esquistossomose/patologia
Esplenopatias/patologia
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
publishDate 1989
dc.date.issued.fl_str_mv 1989
dc.date.accessioned.fl_str_mv 2012-10-23T19:25:47Z
dc.date.available.fl_str_mv 2012-10-23T19:25:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Zilton de Araújo; CARMO, Theomira Mauadie de Azevedo. Treatment of acute experimental schistosomiasis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 84, n. 4, p. 477-484, Oct./Dec. 1989.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5725
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S0074-02761989000400004
identifier_str_mv ANDRADE, Zilton de Araújo; CARMO, Theomira Mauadie de Azevedo. Treatment of acute experimental schistosomiasis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 84, n. 4, p. 477-484, Oct./Dec. 1989.
0074-0276
10.1590/S0074-02761989000400004
url https://www.arca.fiocruz.br/handle/icict/5725
dc.language.iso.fl_str_mv eng
language eng
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instacron_str FIOCRUZ
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