Treatment of acute experimental schistosomiasis
Autor(a) principal: | |
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Data de Publicação: | 1989 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/5725 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. |
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Andrade, Zilton de AraújoCarmo, Theomira Mauadie de Azevedo2012-10-23T19:25:47Z2012-10-23T19:25:47Z1989ANDRADE, Zilton de Araújo; CARMO, Theomira Mauadie de Azevedo. Treatment of acute experimental schistosomiasis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 84, n. 4, p. 477-484, Oct./Dec. 1989.0074-0276https://www.arca.fiocruz.br/handle/icict/572510.1590/S0074-02761989000400004engTreatment of acute experimental schistosomiasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.A model of acute schistosomiasis of the mouse was used to observe whether curative treatment would be followed by an enhancement of the hepatic and splenic lesions, as a consequence of the massive destruction of worms and eggs within the portal system. Mice infected with 50 cercariae of Schistosoma mansoni were treated with both oxamniquine and praziquantel on the 50th day of infection and submitted to a sequential histologic examination from the 2nd to the 45th day after treatment. Although severe focal lesions due to dead and disintegrating worms were present in the livers of the treated animals, no aggravation of the general changes (reactive hepatitis and splenitis, or periovular granulomas) was seen in comparison with a control non-treated group. Of 50 animals treated during the acute phase of schistosomiasis only one died spontaneously, while 16 out of 30 infected controls died before the end of the experiment. The present investigation indicates that curative treatment during the acute phase of schistosomiasis does not enhance previous lesions at first and results in progressive disappearance of the lesions starting six days following chemotherapy.Acute schistosomiasisChemotherapyHepatic and splenic lesionsSchistosoma mansoniHepatopatias Parasitárias/quimioterapiaOxamniquine/uso terapêuticoPraziquantel/uso terapêuticoEsquistossomose/quimioterapiaEsplenopatias/quimioterapiaDoença AgudaAnimaisFemininoGranuloma/parasitologiaHepatopatias Parasitárias/patologiaMasculinoCamundongosEsquistossomose/patologiaEsplenopatias/patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade Za Treatment of acute experimental....pdfAndrade Za Treatment of acute experimental....pdfapplication/pdf495911https://www.arca.fiocruz.br/bitstream/icict/5725/1/Andrade%20Za%20Treatment%20of%20acute%20experimental....pdf285d624c3246850bf035f4928978d5e7MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5725/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTAndrade Za Treatment of acute experimental....pdf.txtAndrade Za Treatment of acute experimental....pdf.txtExtracted texttext/plain8https://www.arca.fiocruz.br/bitstream/icict/5725/5/Andrade%20Za%20Treatment%20of%20acute%20experimental....pdf.txt8d1b69dd9bdc9df4a8073c7a8193c7afMD55THUMBNAILAndrade Za Treatment of acute experimental....pdf.jpgAndrade Za Treatment of acute experimental....pdf.jpgGenerated Thumbnailimage/jpeg2567https://www.arca.fiocruz.br/bitstream/icict/5725/4/Andrade%20Za%20Treatment%20of%20acute%20experimental....pdf.jpg17b07a06c4374208ed4995641b3a53caMD54icict/57252023-03-15 14:32:58.495oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Treatment of acute experimental schistosomiasis |
title |
Treatment of acute experimental schistosomiasis |
spellingShingle |
Treatment of acute experimental schistosomiasis Andrade, Zilton de Araújo Acute schistosomiasis Chemotherapy Hepatic and splenic lesions Schistosoma mansoni Hepatopatias Parasitárias/quimioterapia Oxamniquine/uso terapêutico Praziquantel/uso terapêutico Esquistossomose/quimioterapia Esplenopatias/quimioterapia Doença Aguda Animais Feminino Granuloma/parasitologia Hepatopatias Parasitárias/patologia Masculino Camundongos Esquistossomose/patologia Esplenopatias/patologia |
title_short |
Treatment of acute experimental schistosomiasis |
title_full |
Treatment of acute experimental schistosomiasis |
title_fullStr |
Treatment of acute experimental schistosomiasis |
title_full_unstemmed |
Treatment of acute experimental schistosomiasis |
title_sort |
Treatment of acute experimental schistosomiasis |
author |
Andrade, Zilton de Araújo |
author_facet |
Andrade, Zilton de Araújo Carmo, Theomira Mauadie de Azevedo |
author_role |
author |
author2 |
Carmo, Theomira Mauadie de Azevedo |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Andrade, Zilton de Araújo Carmo, Theomira Mauadie de Azevedo |
dc.subject.en.pt_BR.fl_str_mv |
Acute schistosomiasis Chemotherapy Hepatic and splenic lesions Schistosoma mansoni |
topic |
Acute schistosomiasis Chemotherapy Hepatic and splenic lesions Schistosoma mansoni Hepatopatias Parasitárias/quimioterapia Oxamniquine/uso terapêutico Praziquantel/uso terapêutico Esquistossomose/quimioterapia Esplenopatias/quimioterapia Doença Aguda Animais Feminino Granuloma/parasitologia Hepatopatias Parasitárias/patologia Masculino Camundongos Esquistossomose/patologia Esplenopatias/patologia |
dc.subject.decs.pt_BR.fl_str_mv |
Hepatopatias Parasitárias/quimioterapia Oxamniquine/uso terapêutico Praziquantel/uso terapêutico Esquistossomose/quimioterapia Esplenopatias/quimioterapia Doença Aguda Animais Feminino Granuloma/parasitologia Hepatopatias Parasitárias/patologia Masculino Camundongos Esquistossomose/patologia Esplenopatias/patologia |
description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. |
publishDate |
1989 |
dc.date.issued.fl_str_mv |
1989 |
dc.date.accessioned.fl_str_mv |
2012-10-23T19:25:47Z |
dc.date.available.fl_str_mv |
2012-10-23T19:25:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ANDRADE, Zilton de Araújo; CARMO, Theomira Mauadie de Azevedo. Treatment of acute experimental schistosomiasis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 84, n. 4, p. 477-484, Oct./Dec. 1989. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/5725 |
dc.identifier.issn.none.fl_str_mv |
0074-0276 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1590/S0074-02761989000400004 |
identifier_str_mv |
ANDRADE, Zilton de Araújo; CARMO, Theomira Mauadie de Azevedo. Treatment of acute experimental schistosomiasis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 84, n. 4, p. 477-484, Oct./Dec. 1989. 0074-0276 10.1590/S0074-02761989000400004 |
url |
https://www.arca.fiocruz.br/handle/icict/5725 |
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eng |
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eng |
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openAccess |
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