Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population

Detalhes bibliográficos
Autor(a) principal: Silva, Thiago Magalhães da
Data de Publicação: 2018
Outros Autores: Fiaccone, Rosemeire L, Kehdye, Fernanda de Souza Gomes, Santos, Eduardo Martin Tarazona, Rodrigues, Laura C, Costa, Gustavo Nunes de Oliveira, Figueiredo, Camila A, Neves, Neuza Maria Alcantara, Barreto, Maurício Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/26437
Resumo: Federal University of Bahia (register 003–05/CEP-ISC) and National Council for Ethics in Research (CONEP, resolution number 15 895/2011).
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spelling Silva, Thiago Magalhães daFiaccone, Rosemeire LKehdye, Fernanda de Souza GomesSantos, Eduardo Martin TarazonaRodrigues, Laura CCosta, Gustavo Nunes de OliveiraFigueiredo, Camila ANeves, Neuza Maria AlcantaraBarreto, Maurício Lima2018-05-14T19:39:05Z2018-05-14T19:39:05Z2018SILVA, T. M. et al. Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population. SSM - Population Health, v. 4, p. 301–306, 2018.2352-8273https://www.arca.fiocruz.br/handle/icict/26437Federal University of Bahia (register 003–05/CEP-ISC) and National Council for Ethics in Research (CONEP, resolution number 15 895/2011).Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil / Universidade Estadual do Sudoeste da Bahia. Departamento de Ciências Biológicas. Jequié, BA, BrazilUniversidade Federal da Bahia. Instituto de Matemática. Departamento de Estatística. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, BrasilLondon School of Hygiene and Tropical Medicine. Faculty of Epidemiology. Department of Infectious Disease Epidemiology. London, United KingdomFederal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilFederal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, BrasilRacial inequalities are observed for different diseases and are mainly caused by differences in socioeconomic status between ethnoracial groups. Genetic factors have also been implicated, and recently, several studies have investigated the association between biogeographical ancestry (BGA) and complex diseases. However, the role of BGA as a proxy for non-genetic health determinants has been little investigated. Similarly, studies comparing the association of BGA and self-reported skin colour with these determinants are scarce. Here, we report the association of BGA and self-reported skin colour with socioenvironmental conditions and infections. We studied 1246 children living in a Brazilian urban poor area. The BGA was estimated using 370,539 genome-wide autosomal markers. Standardised questionnaires were administered to the children’s guardians to evaluate socioenvironmental conditions. Infection (or pathogen exposure) was defined by the presence of positive serologic test results for IgG to seven pathogens (Toxocara spp, Toxoplasma gondii, Helicobacter pylori, and hepatitis A, herpes simplex, herpes zoster and Epstein-Barr viruses) and the presence of intestinal helminth eggs in stool samples (Ascaris lumbricoides and Trichiuris trichiura). African ancestry was negatively associated with maternal education and household income and positively associated with infections and variables, indicating poorer housing and living conditions. The self-reported skin colour was associated with infections only. In stratified analyses, the proportion of African ancestry was associated with most of the outcomes investigated, particularly among admixed individuals. In conclusion, BGA was associated with socioenvironmental conditions and infections even in a low-income and highly admixed population, capturing differences that self-reported skin colour miss. Importantly, our findings suggest caution in interpreting significant associations between BGA and diseases as indicative of the genetic factors involved.engElsevierBiogeographical ancestryRacial inequalitiesSocioeconomic statusInfectionsAntecedentes biogeográficosDesigualdades raciaisStatus socioeconômicoInfecçõesBiogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26437/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSilva T Biogeographical ancestry is associated ....pdfSilva T Biogeographical ancestry is associated 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dc.title.pt_BR.fl_str_mv Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population
title Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population
spellingShingle Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population
Silva, Thiago Magalhães da
Biogeographical ancestry
Racial inequalities
Socioeconomic status
Infections
Antecedentes biogeográficos
Desigualdades raciais
Status socioeconômico
Infecções
title_short Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population
title_full Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population
title_fullStr Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population
title_full_unstemmed Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population
title_sort Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population
author Silva, Thiago Magalhães da
author_facet Silva, Thiago Magalhães da
Fiaccone, Rosemeire L
Kehdye, Fernanda de Souza Gomes
Santos, Eduardo Martin Tarazona
Rodrigues, Laura C
Costa, Gustavo Nunes de Oliveira
Figueiredo, Camila A
Neves, Neuza Maria Alcantara
Barreto, Maurício Lima
author_role author
author2 Fiaccone, Rosemeire L
Kehdye, Fernanda de Souza Gomes
Santos, Eduardo Martin Tarazona
Rodrigues, Laura C
Costa, Gustavo Nunes de Oliveira
Figueiredo, Camila A
Neves, Neuza Maria Alcantara
Barreto, Maurício Lima
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Thiago Magalhães da
Fiaccone, Rosemeire L
Kehdye, Fernanda de Souza Gomes
Santos, Eduardo Martin Tarazona
Rodrigues, Laura C
Costa, Gustavo Nunes de Oliveira
Figueiredo, Camila A
Neves, Neuza Maria Alcantara
Barreto, Maurício Lima
dc.subject.other.pt_BR.fl_str_mv Biogeographical ancestry
Racial inequalities
Socioeconomic status
Infections
topic Biogeographical ancestry
Racial inequalities
Socioeconomic status
Infections
Antecedentes biogeográficos
Desigualdades raciais
Status socioeconômico
Infecções
dc.subject.en.pt_BR.fl_str_mv Antecedentes biogeográficos
Desigualdades raciais
Status socioeconômico
Infecções
description Federal University of Bahia (register 003–05/CEP-ISC) and National Council for Ethics in Research (CONEP, resolution number 15 895/2011).
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-05-14T19:39:05Z
dc.date.available.fl_str_mv 2018-05-14T19:39:05Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, T. M. et al. Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population. SSM - Population Health, v. 4, p. 301–306, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/26437
dc.identifier.issn.pt_BR.fl_str_mv 2352-8273
identifier_str_mv SILVA, T. M. et al. Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population. SSM - Population Health, v. 4, p. 301–306, 2018.
2352-8273
url https://www.arca.fiocruz.br/handle/icict/26437
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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