Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients

Detalhes bibliográficos
Autor(a) principal: Oliveira, Ariane Leite de
Data de Publicação: 2013
Outros Autores: Amadeu, Thaís Porto, Gomes, Andressa Cristina de França, Menezes, Vinícius Martins, Nery, José Augusto da Costa, Pinheiro, Roberta Olmo, Sarno, Euzenir Nunes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12571
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
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spelling Oliveira, Ariane Leite deAmadeu, Thaís PortoGomes, Andressa Cristina de FrançaMenezes, Vinícius MartinsNery, José Augusto da CostaPinheiro, Roberta OlmoSarno, Euzenir Nunes2016-01-21T10:46:46Z2016-01-21T10:46:46Z2013OLIVEIRA, Ariane Leite de; et al. Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients. Immunology, n.140, p.47-60, 2013.0019-2805https://www.arca.fiocruz.br/handle/icict/1257110.1111/imm.121081365-2567engWileyHanseníaseHIVCD8+ T cellsHIVLeprosyReversal reactionRole of CD8+ T cells in triggering reversal reaction in HIV/leprosy patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.It has been reported that the initiation of highly active anti-retroviral therapy (HAART) is associated with the development of reversal reaction (RR) in co-infected HIV/leprosy patients. Nevertheless, the impact of HIV and HAART on the cellular immune response to Mycobacterium leprae (ML) remains unknown. In the present study, we observed that ex vivo peripheral blood mononuclear cells (PBMCs) of both RR and RR/HIV patients presented increased percentages of activated CD4+ T cells when compared with the healthy individuals (HC) group. The frequency of CD8+ CD38+ cells increased in the PBMCs of RR/HIV patients but not in RR patients when compared with the HC group. Both RR and RR/HIV skin lesion cells presented similar percentages of activated CD4+ cells, but the numbers of activated CD8+ cells were higher in RR/HIV in comparison to the RR group. The frequency of interferon-c-producing cells was high in response to ML regardless of HIV co-infection. In ML-stimulated cells, there was an increase in central memory CD4+ T-cell frequencies in the RR and RR/HIV groups, but an increase in central memory CD8+ Tcell frequency was only observed in the RR/HIV group. ML increased granzyme B+ effector memory CD8+ T-cell frequencies in the RR/HIV PBMCs, but not in the HC and RR groups. Our data suggest that the increased expression of effector memory CD8+ T cells, together with greater perforin/granzyme B production, could be an additional mechanism leading to the advent of RR in co-infected patients. Moreoever, this increased expression may explain the severity of RR occurring in these patients.reponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12571/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALariane_oliveira_etal_IOC_2013.pdfariane_oliveira_etal_IOC_2013.pdfapplication/pdf1006563https://www.arca.fiocruz.br/bitstream/icict/12571/2/ariane_oliveira_etal_IOC_2013.pdff0236f9958bd43b7896f778cdca82b16MD52TEXTariane_oliveira_etal_IOC_2013.pdf.txtariane_oliveira_etal_IOC_2013.pdf.txtExtracted texttext/plain72969https://www.arca.fiocruz.br/bitstream/icict/12571/3/ariane_oliveira_etal_IOC_2013.pdf.txt20469a8c763d77c3237369ed62b74874MD53icict/125712022-06-24 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dc.title.pt_BR.fl_str_mv Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients
title Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients
spellingShingle Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients
Oliveira, Ariane Leite de
Hanseníase
HIV
CD8+ T cells
HIV
Leprosy
Reversal reaction
title_short Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients
title_full Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients
title_fullStr Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients
title_full_unstemmed Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients
title_sort Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients
author Oliveira, Ariane Leite de
author_facet Oliveira, Ariane Leite de
Amadeu, Thaís Porto
Gomes, Andressa Cristina de França
Menezes, Vinícius Martins
Nery, José Augusto da Costa
Pinheiro, Roberta Olmo
Sarno, Euzenir Nunes
author_role author
author2 Amadeu, Thaís Porto
Gomes, Andressa Cristina de França
Menezes, Vinícius Martins
Nery, José Augusto da Costa
Pinheiro, Roberta Olmo
Sarno, Euzenir Nunes
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Ariane Leite de
Amadeu, Thaís Porto
Gomes, Andressa Cristina de França
Menezes, Vinícius Martins
Nery, José Augusto da Costa
Pinheiro, Roberta Olmo
Sarno, Euzenir Nunes
dc.subject.other.pt_BR.fl_str_mv Hanseníase
HIV
topic Hanseníase
HIV
CD8+ T cells
HIV
Leprosy
Reversal reaction
dc.subject.en.pt_BR.fl_str_mv CD8+ T cells
HIV
Leprosy
Reversal reaction
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2016-01-21T10:46:46Z
dc.date.available.fl_str_mv 2016-01-21T10:46:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Ariane Leite de; et al. Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients. Immunology, n.140, p.47-60, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12571
dc.identifier.issn.none.fl_str_mv 0019-2805
dc.identifier.doi.none.fl_str_mv 10.1111/imm.12108
dc.identifier.eissn.none.fl_str_mv 1365-2567
identifier_str_mv OLIVEIRA, Ariane Leite de; et al. Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients. Immunology, n.140, p.47-60, 2013.
0019-2805
10.1111/imm.12108
1365-2567
url https://www.arca.fiocruz.br/handle/icict/12571
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/12571/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/12571/2/ariane_oliveira_etal_IOC_2013.pdf
https://www.arca.fiocruz.br/bitstream/icict/12571/3/ariane_oliveira_etal_IOC_2013.pdf.txt
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