Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/12571 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. |
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Oliveira, Ariane Leite deAmadeu, Thaís PortoGomes, Andressa Cristina de FrançaMenezes, Vinícius MartinsNery, José Augusto da CostaPinheiro, Roberta OlmoSarno, Euzenir Nunes2016-01-21T10:46:46Z2016-01-21T10:46:46Z2013OLIVEIRA, Ariane Leite de; et al. Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients. Immunology, n.140, p.47-60, 2013.0019-2805https://www.arca.fiocruz.br/handle/icict/1257110.1111/imm.121081365-2567engWileyHanseníaseHIVCD8+ T cellsHIVLeprosyReversal reactionRole of CD8+ T cells in triggering reversal reaction in HIV/leprosy patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.It has been reported that the initiation of highly active anti-retroviral therapy (HAART) is associated with the development of reversal reaction (RR) in co-infected HIV/leprosy patients. Nevertheless, the impact of HIV and HAART on the cellular immune response to Mycobacterium leprae (ML) remains unknown. In the present study, we observed that ex vivo peripheral blood mononuclear cells (PBMCs) of both RR and RR/HIV patients presented increased percentages of activated CD4+ T cells when compared with the healthy individuals (HC) group. The frequency of CD8+ CD38+ cells increased in the PBMCs of RR/HIV patients but not in RR patients when compared with the HC group. Both RR and RR/HIV skin lesion cells presented similar percentages of activated CD4+ cells, but the numbers of activated CD8+ cells were higher in RR/HIV in comparison to the RR group. The frequency of interferon-c-producing cells was high in response to ML regardless of HIV co-infection. In ML-stimulated cells, there was an increase in central memory CD4+ T-cell frequencies in the RR and RR/HIV groups, but an increase in central memory CD8+ Tcell frequency was only observed in the RR/HIV group. ML increased granzyme B+ effector memory CD8+ T-cell frequencies in the RR/HIV PBMCs, but not in the HC and RR groups. Our data suggest that the increased expression of effector memory CD8+ T cells, together with greater perforin/granzyme B production, could be an additional mechanism leading to the advent of RR in co-infected patients. Moreoever, this increased expression may explain the severity of RR occurring in these patients.reponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12571/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALariane_oliveira_etal_IOC_2013.pdfariane_oliveira_etal_IOC_2013.pdfapplication/pdf1006563https://www.arca.fiocruz.br/bitstream/icict/12571/2/ariane_oliveira_etal_IOC_2013.pdff0236f9958bd43b7896f778cdca82b16MD52TEXTariane_oliveira_etal_IOC_2013.pdf.txtariane_oliveira_etal_IOC_2013.pdf.txtExtracted texttext/plain72969https://www.arca.fiocruz.br/bitstream/icict/12571/3/ariane_oliveira_etal_IOC_2013.pdf.txt20469a8c763d77c3237369ed62b74874MD53icict/125712022-06-24 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dc.title.pt_BR.fl_str_mv |
Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients |
title |
Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients |
spellingShingle |
Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients Oliveira, Ariane Leite de Hanseníase HIV CD8+ T cells HIV Leprosy Reversal reaction |
title_short |
Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients |
title_full |
Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients |
title_fullStr |
Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients |
title_full_unstemmed |
Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients |
title_sort |
Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients |
author |
Oliveira, Ariane Leite de |
author_facet |
Oliveira, Ariane Leite de Amadeu, Thaís Porto Gomes, Andressa Cristina de França Menezes, Vinícius Martins Nery, José Augusto da Costa Pinheiro, Roberta Olmo Sarno, Euzenir Nunes |
author_role |
author |
author2 |
Amadeu, Thaís Porto Gomes, Andressa Cristina de França Menezes, Vinícius Martins Nery, José Augusto da Costa Pinheiro, Roberta Olmo Sarno, Euzenir Nunes |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Ariane Leite de Amadeu, Thaís Porto Gomes, Andressa Cristina de França Menezes, Vinícius Martins Nery, José Augusto da Costa Pinheiro, Roberta Olmo Sarno, Euzenir Nunes |
dc.subject.other.pt_BR.fl_str_mv |
Hanseníase HIV |
topic |
Hanseníase HIV CD8+ T cells HIV Leprosy Reversal reaction |
dc.subject.en.pt_BR.fl_str_mv |
CD8+ T cells HIV Leprosy Reversal reaction |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2016-01-21T10:46:46Z |
dc.date.available.fl_str_mv |
2016-01-21T10:46:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
OLIVEIRA, Ariane Leite de; et al. Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients. Immunology, n.140, p.47-60, 2013. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/12571 |
dc.identifier.issn.none.fl_str_mv |
0019-2805 |
dc.identifier.doi.none.fl_str_mv |
10.1111/imm.12108 |
dc.identifier.eissn.none.fl_str_mv |
1365-2567 |
identifier_str_mv |
OLIVEIRA, Ariane Leite de; et al. Role of CD8+ T cells in triggering reversal reaction in HIV/leprosy patients. Immunology, n.140, p.47-60, 2013. 0019-2805 10.1111/imm.12108 1365-2567 |
url |
https://www.arca.fiocruz.br/handle/icict/12571 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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