Different scenarios for Candida parapsilosis fungaemia reveal high numbers of mixed C. parapsilosis and Candida orthopsilosis infections

Detalhes bibliográficos
Autor(a) principal: Barbedo, Leonardo Silva
Data de Publicação: 2015
Outros Autores: Vaz, Catarina, Pais, Célia, Figueiredo-Carvalho, Maria Helena Galdino, Muniz, Mauro de Medeiros, Zancope-Oliveira, Rosely Maria, Sampaio, Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31733
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
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spelling Barbedo, Leonardo SilvaVaz, CatarinaPais, CéliaFigueiredo-Carvalho, Maria Helena GaldinoMuniz, Mauro de MedeirosZancope-Oliveira, Rosely MariaSampaio, Paula2019-02-19T11:49:28Z2019-02-19T11:49:28Z2015BARBEDO, Leonardo Silva et al. Different scenarios for Candida parapsilosis fungaemia reveal high numbers of mixed C. parapsilosis and Candida orthopsilosis infections. Journal of Medical Microbiology, v. 64, p. 7-17, 2015.0022-2615https://www.arca.fiocruz.br/handle/icict/3173310.1099/jmm.0.080655-01473-5644engMicrobiology SocietyDifferent scenarios for Candida parapsilosis fungaemia reveal high numbers of mixed C. parapsilosis and Candida orthopsilosis infectionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Universidade do Minho. Centro de Biologia Molecular e Ambiental. Departamento de Biologia. Braga, Portugal.Universidade do Minho. Centro de Biologia Molecular e Ambiental. Departamento de Biologia. Braga, Portugal.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Nosocomial fungal bloodstream infections (BSI) are increasing significantly in hospitalized patients and Candida parapsilosis has emerged as an important pathogen responsible for numerous outbreaks. The objective of this study was to evaluate C. parapsilosis sensu lato infection scenarios, regarding species distribution and strain relatedness. One hundred isolates of C. parapsilosis sensu lato derived from blood cultures and catheter tips were analysed by multiplex microsatellite typing and by sequencing D1/D2 regions of the ribosomal DNA. Our results indicate that 9.5 % of patients presented infections due to C. parapsilosis and Candida orthopsilosis, 57.1 % due to C. parapsilosis, 28.3 % due to C. orthopsilosis and 4.8 % due to Candida metapsilosis. Eighty per cent of the C. parapsilosis BSIs were due to a single strain that was also identified in the catheter, but in 10 % of the cases C. parasilosis was identified in the catheter but the BSI was due to C. orthopsilosis. There is a significant probability that C. parapsilosis isolates collected from the same patient at more than 3 months interval are of different strains (P = 0.0179). Moreover, several isolates were identified persistently in the same hospital, infecting six different patients. The incidence of polyfungal BSI infections with C. parapsilosis and C. orthopsilosis is reported herein for the first time, emphasizing the fact that the species identified in the catheter is not always responsible for the BSI, thus impacting the treatment strategy. The observation that strains can remain in the hospital environment for years highlights the possible existence of reservoirs and reinforces the need for accurate genotyping tools, such as the markers used for elucidating epidemiological associations and detecting outbreaks.Candida parapsilosisFungaemiaCandida orthopsilosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31733/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Barbedo_Leonardo_etal_INI_2015.pdfve_Barbedo_Leonardo_etal_INI_2015.pdfapplication/pdf255526https://www.arca.fiocruz.br/bitstream/icict/31733/2/ve_Barbedo_Leonardo_etal_INI_2015.pdfa57bd6b60f319dbb4c3a106e56c3c077MD52TEXTve_Barbedo_Leonardo_etal_INI_2015.pdf.txtve_Barbedo_Leonardo_etal_INI_2015.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Different scenarios for Candida parapsilosis fungaemia reveal high numbers of mixed C. parapsilosis and Candida orthopsilosis infections
title Different scenarios for Candida parapsilosis fungaemia reveal high numbers of mixed C. parapsilosis and Candida orthopsilosis infections
spellingShingle Different scenarios for Candida parapsilosis fungaemia reveal high numbers of mixed C. parapsilosis and Candida orthopsilosis infections
Barbedo, Leonardo Silva
Candida parapsilosis
Fungaemia
Candida orthopsilosis
title_short Different scenarios for Candida parapsilosis fungaemia reveal high numbers of mixed C. parapsilosis and Candida orthopsilosis infections
title_full Different scenarios for Candida parapsilosis fungaemia reveal high numbers of mixed C. parapsilosis and Candida orthopsilosis infections
title_fullStr Different scenarios for Candida parapsilosis fungaemia reveal high numbers of mixed C. parapsilosis and Candida orthopsilosis infections
title_full_unstemmed Different scenarios for Candida parapsilosis fungaemia reveal high numbers of mixed C. parapsilosis and Candida orthopsilosis infections
title_sort Different scenarios for Candida parapsilosis fungaemia reveal high numbers of mixed C. parapsilosis and Candida orthopsilosis infections
author Barbedo, Leonardo Silva
author_facet Barbedo, Leonardo Silva
Vaz, Catarina
Pais, Célia
Figueiredo-Carvalho, Maria Helena Galdino
Muniz, Mauro de Medeiros
Zancope-Oliveira, Rosely Maria
Sampaio, Paula
author_role author
author2 Vaz, Catarina
Pais, Célia
Figueiredo-Carvalho, Maria Helena Galdino
Muniz, Mauro de Medeiros
Zancope-Oliveira, Rosely Maria
Sampaio, Paula
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barbedo, Leonardo Silva
Vaz, Catarina
Pais, Célia
Figueiredo-Carvalho, Maria Helena Galdino
Muniz, Mauro de Medeiros
Zancope-Oliveira, Rosely Maria
Sampaio, Paula
dc.subject.en.pt_BR.fl_str_mv Candida parapsilosis
Fungaemia
Candida orthopsilosis
topic Candida parapsilosis
Fungaemia
Candida orthopsilosis
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-02-19T11:49:28Z
dc.date.available.fl_str_mv 2019-02-19T11:49:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv BARBEDO, Leonardo Silva et al. Different scenarios for Candida parapsilosis fungaemia reveal high numbers of mixed C. parapsilosis and Candida orthopsilosis infections. Journal of Medical Microbiology, v. 64, p. 7-17, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31733
dc.identifier.issn.pt_BR.fl_str_mv 0022-2615
dc.identifier.doi.none.fl_str_mv 10.1099/jmm.0.080655-0
dc.identifier.eissn.none.fl_str_mv 1473-5644
identifier_str_mv BARBEDO, Leonardo Silva et al. Different scenarios for Candida parapsilosis fungaemia reveal high numbers of mixed C. parapsilosis and Candida orthopsilosis infections. Journal of Medical Microbiology, v. 64, p. 7-17, 2015.
0022-2615
10.1099/jmm.0.080655-0
1473-5644
url https://www.arca.fiocruz.br/handle/icict/31733
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Microbiology Society
publisher.none.fl_str_mv Microbiology Society
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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